A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction DOI Creative Commons
Gwyneth Kong,

Jaycie Koh,

J I A E E Chia

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Emerging evidence has demonstrated the unfavourable cardiovascular risk of individuals with lean type 2 diabetes mellitus (T2DM). Our study aims to investigate prognostic value T2DM in patients acute myocardial infarction (AMI), stratified by sex. The cohort examines clinical characteristics and long-term outcomes AMI, four phenotypes based on body category—lean T2DM, non-lean non-T2DM non-T2DM. primary outcome was all-cause mortality. Cox regression model constructed associations mortality, adjusted for age, ethnicity, previous AMI type, chronic kidney disease, angiotensin converting enzyme inhibitor or receptor blockers, beta-blockers, smoking status. A 9545 examined, a mean follow-up duration 3.4 ± 2.4 years. Majority had phenotype (40.4%), followed (29.8%), (15.9%), (13.9%). In group, one-quarter (N = 1324), while vast majority (74.5%) non-lean. Individuals tended be female older. Patients highest rates heart failure (23.3%, p < 0.001), cardiogenic shock (9.1%, 0.036), mortality (32.6%, 0.001). that an independent predictor (adjusted hazard ratio [aHR] 1.171, 95% CI 1.040–1.319, 0.009) after adjustment. presence higher following present males (aHR 1.201, 1.037–1.391, 0.015), but not females 1.066, 0.869–1.308, 0.538). T2DM. although this association stronger than females.

Language: Английский

A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction DOI Creative Commons
Gwyneth Kong,

Jaycie Koh,

J I A E E Chia

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Emerging evidence has demonstrated the unfavourable cardiovascular risk of individuals with lean type 2 diabetes mellitus (T2DM). Our study aims to investigate prognostic value T2DM in patients acute myocardial infarction (AMI), stratified by sex. The cohort examines clinical characteristics and long-term outcomes AMI, four phenotypes based on body category—lean T2DM, non-lean non-T2DM non-T2DM. primary outcome was all-cause mortality. Cox regression model constructed associations mortality, adjusted for age, ethnicity, previous AMI type, chronic kidney disease, angiotensin converting enzyme inhibitor or receptor blockers, beta-blockers, smoking status. A 9545 examined, a mean follow-up duration 3.4 ± 2.4 years. Majority had phenotype (40.4%), followed (29.8%), (15.9%), (13.9%). In group, one-quarter (N = 1324), while vast majority (74.5%) non-lean. Individuals tended be female older. Patients highest rates heart failure (23.3%, p < 0.001), cardiogenic shock (9.1%, 0.036), mortality (32.6%, 0.001). that an independent predictor (adjusted hazard ratio [aHR] 1.171, 95% CI 1.040–1.319, 0.009) after adjustment. presence higher following present males (aHR 1.201, 1.037–1.391, 0.015), but not females 1.066, 0.869–1.308, 0.538). T2DM. although this association stronger than females.

Language: Английский

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