Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Cardiovascular
diseases
represent
one
of
the
leading
causes
death
worldwide.
Despite
significant
advances
in
diagnosis
and
treatment
these
diseases,
numerous
challenges
remain
managing
them.
One
is
need
for
replacements
damaged
cardiac
tissues
that
can
restore
normal
function
heart.
Amniotic
membrane,
as
a
biological
scaffold
with
unique
properties,
has
attracted
attention
many
researchers
recent
years.
This
extracted
from
human
placenta,
contains
growth
factors,
cytokines,
other
biomolecules
play
crucial
role
tissue
repair.
Its
anti-inflammatory,
antibacterial,
wound-healing
properties
have
made
amniotic
membrane
promising
option
heart
diseases.
review
article
examines
applications
cardiovascular
By
focusing
on
mechanisms
action
this
results
clinical
studies,
an
attempt
will
be
to
evaluate
potential
using
Additionally,
existing
future
prospects
field
discussed.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: May 31, 2024
Abstract
The
immune
response
holds
a
pivotal
role
in
cardiovascular
disease
development.
As
multifunctional
cells
of
the
innate
system,
macrophages
play
an
essential
initial
inflammatory
that
occurs
following
injury,
thereby
inducing
subsequent
damage
while
also
facilitating
recovery.
Meanwhile,
diverse
phenotypes
and
phenotypic
alterations
strongly
associate
with
distinct
types
severity
diseases,
including
coronary
heart
disease,
valvular
myocarditis,
cardiomyopathy,
failure,
atherosclerosis
aneurysm,
which
underscores
importance
investigating
macrophage
regulatory
mechanisms
within
context
specific
diseases.
Besides,
recent
strides
single-cell
sequencing
technologies
have
revealed
heterogeneity,
cell–cell
interactions,
downstream
therapeutic
targets
at
higher
resolution,
brings
new
perspectives
into
macrophage-mediated
potential
Remarkably,
myocardial
fibrosis,
prevalent
characteristic
most
cardiac
remains
formidable
clinical
challenge,
necessitating
profound
investigation
impact
on
fibrosis
In
this
review,
we
systematically
summarize
functional
plasticity
diseases
unprecedented
insights
introduced
by
technologies,
focus
different
causes
characteristics
especially
relationship
between
inflammation
(myocardial
infarction,
pressure
overload,
dilated
diabetic
cardiomyopathy
aging)
vascular
injury
(atherosclerosis
aneurysm).
Finally,
highlight
preclinical/clinical
targeting
strategies
translational
implications.
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Aug. 5, 2024
Abstract
Chimeric
antigen
receptor
macrophage
(CAR-MΦ)
represents
a
significant
advancement
in
immunotherapy,
especially
for
treating
solid
tumors
where
traditional
CAR-T
therapies
face
limitations.
CAR-MΦ
offers
promising
approach
to
target
and
eradicate
tumor
cells
by
utilizing
macrophages’
phagocytic
antigen-presenting
abilities.
However,
challenges
such
as
the
complex
microenvironment
(TME),
variability
expression,
immune
suppression
limit
their
efficacy.
This
review
addresses
these
issues,
exploring
mechanisms
of
action,
optimal
construct
designs,
interactions
within
TME.
It
also
delves
into
ex
vivo
manufacturing
CAR-MΦ,
discussing
autologous
allogeneic
sources
importance
stringent
quality
control.
The
potential
synergies
integrating
with
existing
cancer
like
checkpoint
inhibitors
conventional
chemotherapeutics
are
examined
highlight
possible
enhanced
treatment
outcomes.
Furthermore,
regulatory
pathways
scrutinized
alongside
established
protocols
cells,
identifying
unique
considerations
essential
clinical
trials
market
approval.
Proposed
safety
monitoring
frameworks
aim
manage
adverse
events,
cytokine
release
syndrome,
crucial
patient
safety.
Consolidating
current
research
insights,
this
seeks
refine
therapeutic
applications,
overcome
barriers,
suggest
future
directions
transition
from
experimental
platforms
standard
care
options.
Cells,
Journal Year:
2025,
Volume and Issue:
14(5), P. 324 - 324
Published: Feb. 20, 2025
Heart
failure
(HF)
is
a
prominent
fatal
cardiovascular
disorder
afflicting
3.4%
of
the
adult
population
despite
advancement
treatment
options.
Therefore,
better
understanding
pathogenesis
HF
essential
for
exploring
novel
therapeutic
strategies.
Hypertrophy
and
fibrosis
are
significant
characteristics
pathological
cardiac
remodeling,
contributing
to
HF.
The
mechanisms
involved
in
development
remodeling
consequent
multifactorial,
this
review,
key
underlying
discussed.
These
have
been
divided
into
following
categories
thusly:
(i)
mitochondrial
dysfunction,
including
defective
dynamics,
energy
production,
oxidative
stress;
(ii)
lipotoxicity;
(iii)
maladaptive
endoplasmic
reticulum
(ER)
(iv)
impaired
autophagy;
(v)
inflammatory
responses;
(vi)
programmed
cell
death,
apoptosis,
pyroptosis,
ferroptosis;
(vii)
endothelial
dysfunction;
(viii)
contractility.
Preclinical
data
suggest
that
there
merit
targeting
identified
pathways;
however,
their
clinical
implications
outcomes
regarding
treating
need
further
investigation
future.
Herein,
we
introduce
molecular
pivotal
onset
progression
HF,
as
well
compounds
related
potential
preventing
or
rescuing
This,
therefore,
offers
an
avenue
design
discovery
therapies
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 27, 2025
Triggering
receptor
expressed
on
myeloid
cells-2
(TREM2)
is
a
transmembrane
immune
that
mainly
macrophages.
As
pathology-induced
signaling
hub,
TREM2
senses
tissue
damage
and
activates
remodeling
in
response.
Previous
studies
have
predominantly
focused
the
pathway
Alzheimer's
disease,
metabolic
syndrome,
cancer.
Recent
research
has
indicated
also
activated
various
cardiovascular
diseases.
In
this
review,
we
summarize
current
understanding
unanswered
questions
regarding
role
of
mediating
metabolism
function
macrophages
atherosclerosis
models
heart
failure.
context
atherosclerosis,
promotes
foam
cell
formation
crucial
for
maintaining
macrophage
survival
plaque
stability
through
efferocytosis
cholesterol
efflux.
myocardial
infarction,
sepsis-induced
cardiomyopathy,
hypertensive
failure
implicated
protective
cardiac
paracrine
functions.
Additionally,
discuss
clinical
significance
elevated
soluble
(sTREM2)
disease
propose
potential
therapies
targeting
TREM2.
The
overall
aim
review
to
highlight
roles
diseases
provide
framework
therapeutic
strategies
Rheumatology Science and Practice,
Journal Year:
2025,
Volume and Issue:
63(1), P. 46 - 54
Published: March 2, 2025
Systemic
lupus
erythematosus
(SLE)
and
rheumatoid
arthritis
(RA)
are
immunoinflammatory
rheumatic
diseases
(IRDs)
associated
with
a
high
risk
of
developing
cardiovascular
(CVD).
Despite
advances
in
diagnostics
therapy,
the
pathology
is
1.8–2.8
times
higher
than
individuals
without
autoimmune
diseases,
increased
at
an
early
stage
disease,
clinical
activity,
disease
duration,
need
for
hospitalization,
mortality.
According
to
modern
data,
CVD
patients
SLE
RA
considered
consequence
systemic
(subclinical)
inflammatory
process
induced
by
pathological
activation
main
components
innate
acquired
immunity,
more
often
low
or
moderate
risk.
The
cells
immune
system
involved
development
maintenance
inflammation
monocytes
macrophages.
There
two
phenotypes
macrophages:
M1
(proinflammatory)
M2
(anti-inflammatory).
macrophages
produce
proinflammatory
cytokines
interleukin
(IL)
6,
IL-23,
tumor
necrosis
factor
α,
which
maintaining
engaging
new
cells,
while
secrete
anti-inflammatory
mediators
limit
inflammation.
It
assumed
that
imbalance
between
may
underlie
SLE,
RA,
manifestations
CVD.
Currently,
various
diagnostic
non-invasive
methods
used
visualize
subclinical
CVD,
results
can
provide
additional
values
stratification
asymptomatic
patients.
importance
monitoring
arterial
stiffness
as
one
markers
characterizing
vascular
remodeling
signs
atherosclerosis
has
been
confirmed.
Several
studies
have
demonstrated
effectiveness
echocardiographic
techniques
(tissue
Doppler),
especially
global
longitudinal
strain
using
speckle
tracking,
assessing
cardiac
damage
left
ventricular
diastolic
dysfunction.
Thus,
clarifying
relationship
monocyte
disorders
will
contribute
understanding
common
pathogenetic
mechanisms
IRDs
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 28, 2025
The
intimate
correlation
between
cardiovascular
diseases
and
other
organ
pathologies,
such
as
metabolic
kidney
diseases,
underscores
the
intricate
interactions
among
these
organs.
Understanding
inter-organ
communications
is
crucial
for
developing
more
precise
drugs
effective
treatments
systemic
diseases.
While
animal
models
have
traditionally
been
pivotal
in
studying
interactions,
human-induced
pluripotent
stem
cells
(hiPSCs)
offer
distinct
advantages
when
constructing
vitro
models.
Beyond
conventional
two-dimensional
co-culture
model,
hiPSC-derived
humanoid
organoids
emerged
a
substantial
advancement,
capable
of
replicating
essential
structural
functional
attributes
internal
organs
vitro.
This
breakthrough
has
spurred
development
multilineage
organoids,
assembloids,
organoids-on-a-chip
technologies,
which
allow
enhanced
physiological
relevance.
These
technologies
shown
great
potential
mimicking
coordinated
organogenesis,
exploring
disease
pathogenesis,
facilitating
drug
discovery.
As
central
system,
heart
serves
focal
point
an
extensively
studied
network
interactions.
review
focuses
on
advancements
challenges
organs,
presenting
comprehensive
exploration
this
cutting-edge
approach
research.
Journal of Pharmacology and Experimental Therapeutics,
Journal Year:
2025,
Volume and Issue:
392(4), P. 103531 - 103531
Published: March 5, 2025
Stem
cell
transplantation
is
a
promising
treatment
for
repairing
damaged
tissues,
but
challenges
like
immune
rejection
and
ethical
concerns
remain.
Mesenchymal
stem
cells
(MSCs)
offer
high
differentiation
potential
regulatory
activity,
showing
promise
in
treating
diseases
such
as
gynecological,
neurological,
kidney
disorders.
With
scientific
progress,
MSC
applications
are
overcoming
traditional
limitations.
In
MSCs-macrophage
coculture,
MSCs
transform
macrophages
into
anti-inflammatory
M2
macrophages,
reducing
inflammation,
whereas
enhance
osteogenic
differentiation.
This
coculture
vital
modulation
tissue
repair,
with
models
varying
by
contact
type
dimensional
arrangements.
Factors
techniques
ratios
influence
outcomes.
Benefits
include
improved
heart
function,
wound
healing,
reduced
lung
accelerated
bone
repair.
Challenges
optimizing
conditions.
study
reviews
the
methodologies,
factors,
mechanisms
of
MSC-macrophage
providing
foundation
engineering
applications.
SIGNIFICANCE
STATEMENT:
review
underlines
significant
role
mesenchymal
cell-macrophage
application.
