Dermatologic Clinics, Journal Year: 2024, Volume and Issue: 42(4), P. 577 - 589
Published: June 1, 2024
Language: Английский
Journal of Dermatological Treatment, Journal Year: 2024, Volume and Issue: 35(1)
Published: May 9, 2024
Background/purpose Dystrophic epidermolysis bullosa (DEB), a rare genetic skin disease caused by loss-of-function mutations in COL7A1, the gene encoding type VII collagen (COL7), is characterized blistering, scarring, and extracutaneous manifestations that markedly reduce patient quality-of-life. Beremagene geperpavec-svdt ('B-VEC') therapy employing non-integrating, replication-defective herpes simplex virus 1 (HSV-1)-based vector two copies of full-length human COL7A1 to restore COL7 protein after topical administration DEB wounds. B-VEC was approved United States 2023 as first treatment for DEB. However, few providers have experience with use this therapy.
Language: Английский
Citations
4
Dermatologic Therapy, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Atopic dermatitis (AD) is a common skin disorder. Although wide range of therapeutic regimens are available, they have some limitations, including high medical costs. However, evidence suggests that adjuvant such as water bathing inexpensive and effective approaches for the management AD. Bathing with either tap or seawater alone can improve AD symptoms signs. Combination topic emollient corticosteroids synergically alleviate The underlying mechanisms by which benefits include improvements in epidermal function, inhibition mast cell Langerhans reductions serine protease expression activity, cytokine expression, upregulation levels antioxidant enzymes, well antimicrobial peptides. In this review, we summarize effects on both humans murine models mechanisms.
Language: Английский
Citations
0
Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 132(6), P. 678 - 685
Published: Feb. 13, 2024
Language: Английский
Citations
3
Pediatric Dermatology, Journal Year: 2024, Volume and Issue: 41(4), P. 726 - 727
Published: Feb. 12, 2024
Abstract Bleach baths are an important adjunct in the management of atopic dermatitis. However, many homes do not have bath tubs. We tried to overcome this by soaking a cotton pajama suit or Indian kurta dilute bleach solution and then having child wear it for ten minutes. This is done two three times week, as standard tub baths. technique eleven patients with satisfactory outcomes no adverse effects.
Language: Английский
Citations
2
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2), P. 100022 - 100022
Published: May 2, 2024
Atopic dermatitis, a common chronic inflammatory skin disease, has an unclear etiology and may involve multiple factors such as genetic predisposition, immune abnormalities, impaired barrier function. Currently, there is no specific medication available for the complete cure of atopic dermatitis. The current treatment approaches mainly focus on symptom relief control rather than curative treatment. Some commonly used medications topical corticosteroids immunosuppressants, have certain adverse reactions side effects. This review summarizes research progress natural extracts in aiming to provide foundation development safe side-effect-free medications.
Language: Английский
Citations
2
Pediatric Reports, Journal Year: 2024, Volume and Issue: 16(1), P. 57 - 68
Published: Jan. 8, 2024
Atopic dermatitis is a chronic inflammatory skin disease. The treatment plays an important role in influencing the patients’ quality of life. basic management consists appropriate cleansing, including bathing and eventually using additives. Recommendations regarding frequency duration bathing, water temperature usefulness additives are widely different, often leading to confusion among patients. This review aims give insights into best practices use atopic children. Several additives, bleach baths, commercial baby cleansers, bath oils salt, appear be promising adjunctive therapies for due their anti-inflammatory, anti-bacterial, anti-pruritus barrier repair properties through different mechanisms action. However, efficacy safety not fully understood some cases. other such as acidic more natural substances (green tea extracts, pine tar, sodium bicarbonate), still under investigation. Further studies needed determine optimal achieve clinical benefit safely.
Language: Английский
Citations
1
Journal of the American Academy of Dermatology, Journal Year: 2024, Volume and Issue: 91(2), P. 290 - 299
Published: April 9, 2024
Language: Английский
Citations
1
International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 566 - 577
Published: Aug. 1, 2024
Abstract Introduction Stratum corneum (SC) is essential for skin barrier function, mitigating water loss and shielding against potentially harmful substances allergens. The SC's lipid matrix, arranged in a lamellar structure, integral to its protective role. Our study explores the restoration effects of multilamellar cream with an acidic pH compared basic placebo on physiology interaction microbiome after stress induction via tape stripping (TS). Materials Methods In this double‐blind study, 14 healthy participants aged 21–58 years were assessed pre‐ post‐tape stripping, followed by days application test evaluations 7, 17 sustained effects. Skin was analysed terms epidermal SC hydration surface pH. 16S rRNA amplicon sequencing gene using Illumina MiSeq, subsequent species identification. Results showed significant improvements repair verum, particularly application, while both creams initially enhanced stratum hydration. No changes surface‐pH detected. analysis revealed that TS slightly decreased alpha diversity, trend verum significantly reversed, enhancing diversity beyond baseline levels days. Overall, contributed broader microbial phyla over time, no abundance specific genera or noted between treatments. Discussion Conclusion delineates efficacy pH‐optimized recovery post‐sequential TS, contrast unstructured placebo. Verum improved function at day 14, evident treatment period. Furthermore, formulation facilitated restitution cutaneous key indicator ecology, underscoring symbiotic relationship integrity composition. These findings underscore importance emollient structures dermatological therapeutics, potential implications design advanced skincare interventions holistically support resilience homeostasis.
Language: Английский
Citations
1
Dermatologic Clinics, Journal Year: 2024, Volume and Issue: 42(4), P. 577 - 589
Published: June 1, 2024
Language: Английский
Citations
0