Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

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Sex, race, and BMI in clinical trials of medications for obesity over the past three decades: a systematic review

The Lancet Diabetes & Endocrinology, Journal Year: 2024, Volume and Issue: 12(6), P. 414 - 421

Published: May 6, 2024

Language: Английский

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Subgroup analysis by sex and baseline BMI in people with a BMI ≥27 kg/m² in the phase 2 trial of survodutide, a glucagon/GLP‐1 receptor dual agonist

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Aim To explore the effects of sex and baseline body mass index (BMI) on efficacy safety survodutide in people with a BMI ≥27 kg/m 2 . Materials Methods Totally 387 (aged 18–75 years, , without diabetes) were randomized 1:1:1:1:1 to once‐weekly subcutaneous (0.6, 2.4, 3.6 or 4.8 mg) placebo for 46 weeks (20‐week dose escalation; 26‐week maintenance). Participants categorized according BMI. Data analysed descriptively full analysis set (FAS), assigned at randomization (planned treatment) using on‐treatment data all censored COVID‐19‐related treatment discontinuations. ( ClinicalTrials.gov number: NCT04667377). Results After treatment, females had greater reductions bodyweight waist circumference than males. lower proportional those higher BMI; trend was reversed circumference. Rates adverse events (AEs) comparable between subgroups Nausea most frequently reported gastrointestinal AE subgroups. Conclusions In associated clinically meaningful when compared placebo, prespecified based BMI, tolerated doses tested.

Language: Английский

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Boosting Dietary Compliance After Bariatric Surgery: Winning Tactics for Patients

Journal of Evaluation in Clinical Practice, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 20, 2025

ABSTRACT Background Bariatric metabolic surgery has emerged as a pivotal intervention for managing obesity, with strict adherence to postoperative nutritional guidelines being paramount patient outcomes. This study seeks evaluate dietary compliance levels and the factors that influence them among patients who have undergone bariatric surgery, offering insights enhance clinical strategies. Method Our research encompassed underwent at our institution from February 2022 December 2023. We utilised validated scale assess how well followed advice. To determine linked compliance, we conducted Pearson correlation logistic regression analyses. Results The comprised 176 individuals concerning 60.23% exhibiting inadequate compliance. analysis revealed significant correlations between poor several demographic factors: age ( r = −0.516), gender 0.467), educational attainment −0.605) monthly household income −0.558). Logistic confirmed (OR −2.157, 95% CI: −3.120 −1.403), 2.006, 1.821–2.665), education level −3.081, −4.147 −1.679), average family −2.847, −3.516 −1.225) independent predictors of in post‐bariatric patients. Conclusion high incidence following is concern notably influenced by variables such age, gender, economic status. It imperative healthcare professionals consider these when developing personalised interventions aimed improving within this group.

Language: Английский

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Social, cultural and ethnic determinants of obesity: from pathogenesis to treatment

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103901 - 103901

Published: Feb. 1, 2025

Obesity is a multifactorial disease influenced by several factors including poor diet, physical inactivity, and genetic predisposition. In recent years, the social environmental context, along with race/ethnicity gender, have been recognized as influencing obesity risk beyond traditional factors. This review aims to increase knowledge of these causal determinants their implications for treatment management obesity, addressing not only individual but also societal sphere. A growing body evidence emphasizes interaction between environments in shaping personal behaviors related obesity. Social disparities, such socioeconomic status (income, education, employment), racial/ethnic differences, contribute significantly weight gain from childhood adulthood. These cardiovascular factors, independent clinical demographic variables, may lead stigma discrimination against those affected. prevention solutions, community programs national policies, be more effective if they address social, ethnic barriers. Understanding requires comprehensive approach that includes environmental, psychological well biological causes, help experts develop interventions tailored diseases.

Language: Английский

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An elevated triglyceride-glucose index in the first-trimester predicts adverse pregnancy outcomes: a retrospective cohort study

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

The relationship of the first-trimester triglyceride-glucose (TyG) index with GDM (gestational diabetes mellitus) and other adverse pregnancy outcomes has yet to be fully understood. This study aims investigate between TyG risk in pregnant women. data for retrospective cohort were derived from Maternal Child Health Hospital Longgang District, Shenzhen, China. To calculate index, health indicators measured early period (<14 gestational weeks), including triglycerides fasting blood glucose levels Multivariable regression analysis subgroup used ascertain independent association possibility outcomes. Interaction was performed assess potential heterogeneity associations among subgroups. Nonlinear predictive value explored using restricted cubic splines receiver operating characteristic (ROC) curves. discrimination accuracy adjusted model evaluated calibration curves, Brier scores, decision curve (DCA). Mediation conducted impact PE (preeclampsia) as intermediaries on Preterm delivery. included a 11,942 women, an average 8.36 ± 0.41. Logistic showed that after adjusting covariates, each 1-unit increase increased by 2.21-fold, this result significantly different across all quartiles. Compared lowest quartile group, highest group had (OR: 2.89; 95% CI 1.39 ~ 6.50), GH hypertension) 1.47; 1.07 2.02), delivery 1.75; 1.21 2.56).The stratification interaction confirmed validity our results. However, found no statistically significant low birth weight macrosomia. identified partial mediating factors preterm delivery, variance contributions 7.23% 20.33%. demonstrated area under (AUC) values ROC curves GDM, PE, GH, 0.61, 0.67, 0.58, 0.56, respectively. combination maternal age, pre-pregnancy body mass predicted better than alone (p < 0.01).After adjustment confounders, good net benefit predicting outcomes, supported analysis. An elevated correlates heightened delivery.The presents promising tool more effectively identifying populations at

Language: Английский

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Onboarding Obesity Management in Cardiovascular Care: A Cardiologist's Guide to Latest Advances

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 100987 - 100987

Published: April 1, 2025

In recent decades, the prevalence of obesity has escalated markedly, becoming a serious epidemic and public health crisis requiring urgent sustained attention. Obesity is associated with large number conditions, including cardiovascular diseases (CVDs), which contribute to an increase in mortality overall global challenge. Despite its high morbidity mortality, most healthcare practitioners perceive as outcome unhealthy lifestyle rather than disease by itself. As such, either overlooked or considered minor risk factor for CVD clinical practice, among others. Since (CV) causes remain leading cause death patients obesity, cardiologists are frequently visited professionals can play essential role addressing this disease. complex, chronic, relapsing yet treatable that stems from disruption body's homeostatic, hedonic, cognitive systems, result interplay between genetic, metabolic, inflammatory, vascular, environmental behavioral, pharmacological factors. With early recognition assessment, management successfully improve life expectancy reduce CV risk. review, concise overview was provided, focusing on pathophysiology, diagnosis, management. The correlation CVDs further discussed, highlighting significance education patient outcomes prevent progression related comorbidities.

Language: Английский

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Menstrual and sexual functions in female patients after sleeve gastrectomy due to obesity: obesity and sexual function

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Purpose Obesity is a systemic condition that increasingly common. negatively affects sexual function and menstrual regularity. Therefore, losing excess weight important for women's health. Methods The change in body mass index (BMI) loss (EWL) of sexually active female patients who underwent laparoscopic sleeve gastrectomy (LSG) were evaluated by general surgeon. preoperative postoperative periods compared gynecologist using the survey method patterns, dysmenorrhea complaints, if any, with Female Sexual Function Scale (FSFI). Results study included 55 mean ± standard deviation BMI on day operation 45.32 5.82 kg/m2. In first year, significantly reduced to 27.88 1.99 ( p < 0.001). percentage EWL at end 1 year was 73.09 19.74 after LSG. median (range) FSFI score 26.30 (22.70–27.70). One LSG, improved 34.50 (30.20–35.30) Compared period before surgery, frequency intercourse increased from two-to-three times week Conclusion Women's desires are fundamental human right contribute well-being. Thus, it treat dysfunction. results present demonstrate significant improvement dysfunctions LSG an effective procedure may be recommended obese women dysfunction problems. Graphical abstract

Language: Английский

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Effects of Obesity on Female Fertility: Mechanisms, Clinical Consequences and Management Strategies

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1646 - 1653

Published: Jan. 1, 2025

Language: Английский

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Impact of aging on maximal oxygen uptake in female runners and sedentary controls

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 193, P. 112476 - 112476

Published: June 3, 2024

The present study aimed to compare V̇O

Language: Английский

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