Agents of Systemic and Subcutaneous Mucormycosis and Entomophthoromycosis DOI
Dea García-Hermoso, Alexandre Alanio, Fanny Lanternier

et al.

ClinMicroNow, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 23

Published: Aug. 11, 2023

Abstract Mucormycosis and entomophthoromycosis are invasive fungal infections caused by environmental pauciseptate filamentous fungi. Entomophthoromycosis presents as subcutaneous with favorable outcome after prolonged azole therapy without surgery, although it is potentially associated disfiguring lesions. can develop in HIV‐infected patients intravenous‐drug users. The diagnosis of mucormycosis should be considered an emergency, because delaying will affect outcome. One the major differences between that former occurs mainly predisposed individuals, whereas latter mostly apparently immunocompetent hosts. Culture results always interpreted light clinical presentation along direct examination and/or histopathology. Therapeutic strategies for basidiobolomycosis conidiobolomycosis not standardized lack trials these rare infections.

Language: Английский

Ocular Manifestations of COVID-19 DOI Creative Commons
Hannah Ng, Daniel Andrew Richard Scott, Helen V. Danesh‐Meyer

et al.

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 102, P. 101285 - 101285

Published: June 24, 2024

There is an increasing body of knowledge regarding how COVID-19 may be associated with ocular disease varying severity and duration. This article discusses the literature on manifestations COVID-19, including appraisal current evidence, suggested mechanisms action, comorbidities risk factors, timing from initial infection to diagnosis clinical red flags. The primarily comprises case reports series which inevitably lack control groups evidence support causality. However, these early data have prompted development larger population-based laboratory studies that are emerging. As new become available, a better true effects eye will possible. While pandemic was officially declared no longer "global health emergency" by World Health Organization (WHO) in May 2023, numbers continue rise. Reinfection different variants predicted lead growing cumulative burden disease, particularly as more chronic, multi-organ sequelae apparent potentially significant implications. postulated due three main mechanisms: firstly, there dysregulated immune response linked inflammatory disease; secondly, patients greater tendency towards hypercoagulable state, leading prothrombotic events; thirdly, severe requiring hospitalisation immunosuppressed administered corticosteroids or such diabetes mellitus at increased secondary infections, endophthalmitis rhino-orbital-mucormycosis. Reported ophthalmic associations therefore, include range conditions conjunctivitis, scleritis, uveitis, endogenous endophthalmitis, corneal graft rejection, retinal artery vein occlusion, non-arteritic ischaemic optic neuropathy, glaucoma, neurological orbital sequelae. With need consider telemedicine consultation view COVID-19's infectivity, understanding present during following essential ensure appropriately triaged, prompt in-person examination for management sight-threatening life-threatening diseases.

Language: Английский

Citations

4
Interdisziplinäre Therapie der Erkrankungen der Orbita DOI Creative Commons
Anja Eckstein,

Hans‐Jürgen Welkoborsky

Laryngo-Rhino-Otologie, Journal Year: 2024, Volume and Issue: 103(S 01), P. S43 - S99

Published: May 1, 2024

Zusammenfassung Die Diagnostik und Therapie von Erkrankungen der Orbita ist eine interdisziplinäre Aufgabe, an u.a. die Fachdisziplinen HNO-Heilkunde, Augenheilkunde, Radiologie, Strahlentherapie, MKG-Chirurgie, Endokrinologie Pädiatrie beteiligt sind. Der vorliegende Übersichtsartikel stellt Zusammenstellung häufigsten dar, mit denen HNO-Heilkunde Augenheilkunde interdisziplinär befasst Es werden akuten entzündlichen incl. orbitaler Komplikationen, autoimmunologischen endokrinen Orbitopathie, tumorösen besprochen. Neben Beschreibung Klinik wird besonderes Augenmerk auf gelegt. Abgerundet wichtigsten chirurgischen Zugangswege zur Orbita, ihre Indikationen mögliche Komplikationen. Autoren haben versucht, trotz knappen Darstellung relevanten Fakten zu beschreiben.

Citations

2
Clinical Phenotypes of COVID-19 Associated Mucormycosis (CAM): A Comprehensive Review DOI Creative Commons
Maria Panagiota Almyroudi, Karolina Akinosoglou, Jordi Rello

et al.

Diagnostics, Journal Year: 2022, Volume and Issue: 12(12), P. 3092 - 3092

Published: Dec. 8, 2022

A mucormycosis surge was reported during the COVID-19 pandemic in India. literature search until 14 July 2022, with aim of updating COVID-19-associated (CAM), identified 663 studies and 88 met inclusion criteria (8727 patients). India 8388 patients, Egypt 208 Europe 40. Rhino-orbito-cerebral (ROCM) among 8082 (98.3%) followed by 98 (1.2%) pulmonary. In India, 82.6% patients had diabetes mellitus, 82% receiving corticosteroids. Europe, 75% presented pulmonary CAM, 32.5% 40% were immunocompromised. CAM at a median 17.4 days (IQR 7.5 days) post diagnosis, PCR performed five studies. Rhino-orbital invasion is clinically obvious, while cerebral involvement presents cavernous sinus thrombosis, meningitis cerebrovascular disease. Symptoms usually overlap severe pneumonia. High-dose liposomal Amphotericin B (and early surgical debridement ROCM) are mainstay therapy. The mortality rate estimated to be 21.4% 31.9%), increased presence (80% 50%) or (50% 63.9%). summary, different clinical phenotypes need distinguished, influenced geographical presentation. Opportunities exist for diagnosis therapy optimization, based on earlier high-dose antifungal therapy, source control, strict glycemic control restriction steroids oxygen requirements.

Language: Английский

Citations

9
Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis DOI
Aditya Sharma, Md. Aftab Alam, Shivang Dhoundiyal

et al.

Infectious Disorders - Drug Targets, Journal Year: 2023, Volume and Issue: 24(1)

Published: Aug. 23, 2023

Mucormycosis is a serious and invasive fungal infection caused by Mucorales fungi. This review article provides concise overview of the pathogenesis, epidemiology, microbiology, diagnosis mucormycosis. The introduction section highlights key microbiological properties pathogen delves into underlying mechanisms mucormycosis including invasion proliferation fungus within host. description disease focuses on epidemiology mucormycosis, its incidence, risk factors, geographical distribution. It also explores specific context about COVID-19 diabetes mellitus, highlighting increased susceptibility observed in individuals with these conditions. A case study illustrates clinical manifestations challenges associated emphasizing importance early detection. Additionally, discusses significance assessment, radiological imaging, tests for accurate timely detection infection. Regarding treatment, covers various therapeutic approaches, antifungal therapy, surgical interventions, management predisposing limitations treatment options are addressed. aims to provide comprehensive understanding equipping healthcare professionals valuable insights diagnostic strategies. By enhancing knowledge awareness this infection, can improve patient outcomes through appropriate management.

Language: Английский

Citations

4
Comparative Evaluation of COVID-19 Associated Mucormycosis (CAM) and Non-COVID-19-associated Mucormycosis (non-CAM) DOI Open Access
Ebru Oruç, Tuğba Arslan Gülen, Tuba Turunç

et al.

Journal of College of Physicians And Surgeons Pakistan, Journal Year: 2023, Volume and Issue: 33(2), P. 153 - 157

Published: Feb. 1, 2023

Objective: To compare COVID-19 associated mucormycosis cases (CAM) with non-COVID-19 (non-CAM) followed as in-patients.

Language: Английский

Citations

1
COVID-19 associated rhino-orbital-cerebral mucormycosis in patients with diabetes and comorbid conditions DOI
Çağlar Eker

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 473 - 483

Published: Jan. 1, 2024

Language: Английский

Citations

0
INCIDENCE OF RHINO-ORBITAL MUCORMYCOSIS IN PATIENTS WITH IMMUNOSUPPRESSION AFTER COVID-19 DOI
Diana Zabolotna

OTORHINOLARYNGOLOGY, Journal Year: 2024, Volume and Issue: unknown, P. 14 - 22

Published: Jan. 1, 2024

Relevance: Rhino-orbito-cerebral mucormycosis (ROCM) is a fulminant and dangerous disease caused by invasive fungi. These pathogens, which are present saprophytically everywhere in the environment, can get caught into body during breathing. Then they expand mucosa of nasal cavity paranasal sinuses, after that - spread to palate, orbit brain. It should be noted rapidly progressing angioinvasive infection. Before occurrence COVID-19 pandemic, this pathology was endemic mostly found countries with tropical subtropical climate. However, onset second wave pandemic appearance COVID-associated fungal rhinosinusitis, cases have unprecedented increased not only climates, but also throughout world. Objective: study risk factors manifestations patients ROCM prevent find possibility early diagnosis treatment pathology. Materials methods: In State Institution “O.S. Kolomiychenko Institute Otolaryngology National Academy Medical Sciences Ukraine” 2020-2023 we examined treated 6 signs rhinosinusitis. All underwent X-ray examinations, included computed tomography (CT) chest, cavity, sinuses. Enhanced magnetic resonance imaging (MRI) performed orbital or intracranial spreading suspected. Results discussion: According anamnesis, all became ill Acute rhinosinusitis various degrees severity began observed suffering from infection, few weeks osteomyelitis bones skull appeared varying damage spreading. 4 out had diabetes severity, 1 patient HIV-infected hepatitis C, diagnosed cancer. 3 complicated on chronic phlegmon fistula inner corner eye. Destruction endonasal bone structures patients. suffered ptosis, amaurosis thrombosis both cavernous sinuses internal carotid arteries. The ethmoid were involved pathological process cases, maxillary – patients, sphenoid 3, frontal 2 cases. surgical treatment, depended degree damage, clinical radiological assessment disease. tissue affected areas taken for histopathological examination Unfortunately, there no pathognomonic symptoms mucormycosis, it may nonspecific occult such as persistent fever, congestion, facial pain, exophthalmos, diplopia, visual loss, altered mental status. Numbness skin face indicate an process. Conclusion. Rhino-orbital-cerebral rare There significant increase its frequency pandemic. We didn`t notice rhino-orbital-cerebral before epidemic Ukraine. This considered due infections has expanded, kept mind absence blackened necrotic scabs diagnostic endoscopy does exclude mucormycosis. A high index suspicion necessary any immunosuppressive conditions, especially history maxilla and/or base prompt doctor immediately re-examine patient. Key words: acute invasion, diabetes, conditions.

Language: Английский

Citations

0
Degree of Orbital Affections in Cases of Nasal Mucormycosis Associated with COVID-19 DOI Open Access

Ezzeddin Mohamed El Sheikh,

Hani Mohamed Ali El Shamy,

Manar Muhammad Abdel Rehim

et al.

The Egyptian Journal of Hospital Medicine, Journal Year: 2023, Volume and Issue: 91(1), P. 4288 - 4293

Published: April 1, 2023

Background: The incidence of acute invasive fungal sinusitis (AIFS) increased without obvious cause in the COVID-19 era subsequently there is a burden on health care system.Objective: In our study, we attend to find best assessment for orbital affections patients with AIFS and decrease morbidity rates.Therefore, present study aimed assess functional outcome endoscopic debridement medical treatment cases affection.Patients methods: A one-arm interventional was conducted Orhinolaryngology, Head Neck Surgery Department, Zagazig University Hospitals.The included 19 patients, aged between 31 65 years, who had symptoms associated nasal mucormycosis history infection.Patients have undergone surgery, under general anesthesia. Results:The performed intraoperatively revealed that significant percentage septal necrosis (31.6%), superior turbinate (10.5%) inferior (47.4%).Furthermore, all showed middle which considered be classical sign by examination.Regarding prognosis mortality, most (78.9%) improvement while 21.1% died. Conclusion:Early combined surgical can save lives salvage eyes.

Language: Английский

Citations

0
Agents of Systemic and Subcutaneous Mucormycosis and Entomophthoromycosis DOI
Dea García-Hermoso, Alexandre Alanio, Fanny Lanternier

et al.

ClinMicroNow, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 23

Published: Aug. 11, 2023

Abstract Mucormycosis and entomophthoromycosis are invasive fungal infections caused by environmental pauciseptate filamentous fungi. Entomophthoromycosis presents as subcutaneous with favorable outcome after prolonged azole therapy without surgery, although it is potentially associated disfiguring lesions. can develop in HIV‐infected patients intravenous‐drug users. The diagnosis of mucormycosis should be considered an emergency, because delaying will affect outcome. One the major differences between that former occurs mainly predisposed individuals, whereas latter mostly apparently immunocompetent hosts. Culture results always interpreted light clinical presentation along direct examination and/or histopathology. Therapeutic strategies for basidiobolomycosis conidiobolomycosis not standardized lack trials these rare infections.

Language: Английский

Citations

0
Agents of Systemic and Subcutaneous Mucormycosis and Entomophthoromycosis DOI
Dea García-Hermoso, Alexandre Alanio, Fanny Lanternier

et al.

ClinMicroNow, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 23

Published: Aug. 11, 2023

Abstract Mucormycosis and entomophthoromycosis are invasive fungal infections caused by environmental pauciseptate filamentous fungi. Entomophthoromycosis presents as subcutaneous with favorable outcome after prolonged azole therapy without surgery, although it is potentially associated disfiguring lesions. can develop in HIV‐infected patients intravenous‐drug users. The diagnosis of mucormycosis should be considered an emergency, because delaying will affect outcome. One the major differences between that former occurs mainly predisposed individuals, whereas latter mostly apparently immunocompetent hosts. Culture results always interpreted light clinical presentation along direct examination and/or histopathology. Therapeutic strategies for basidiobolomycosis conidiobolomycosis not standardized lack trials these rare infections.

Language: Английский

Citations

0