From compulsivity to compulsion: the neural basis of compulsive disorders

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(5), P. 313 - 333

Published: April 9, 2024

Language: Английский

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A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102240 - 102240

Published: Feb. 22, 2024

Language: Английский

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Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 116 - 127

Published: Jan. 11, 2025

This study investigates the effects of transcranial direct current stimulation (tDCS) on brain network connectivity in individuals with obsessive-compulsive disorder (OCD). In a randomized, double-blind, sham-controlled experimental design anodal tDCS (vs. sham) was applied total 43 right-handed patients OCD, targeting right pre-supplementary motor area (pre-SMA). Cathodal reference electrode put left pre-SMA. The set as 2 mA, duration either 30 s (sham) or 1200 s. Concurrent resting-state functional MRI data were collected following (or stimulation. We employed regression dynamic causal modelling (rDCM) to extract whole effective (EC) matrices subsequently analyzing these through graph theory approaches examine changes activity across different scales. found that compared sham caused significant local connectivity. Increased recruitment level detectable sensorimotor (SMN), indicating enhanced intra-network after active tDCS. Clustering coefficient and efficiency also be increased same area. No regard global Current findings indicate single-session can effectively alter connectivities within SMN OCD patients. Given relevance connected regions for pathophysiology we believe areas might constitute an intervention normalize altered OCD. used single session, which may not reflect long-term effects.

Language: Английский

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Grey matter volume differences in pediatric obsessive–compulsive disorder: a meta-analysis of voxel-based morphometry studies

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

Obsessive–compulsive disorder (OCD) is one of the most commonly seen mental disorders onset from childhood. The neural mechanisms underlying OCD development and maintenance remain poorly understood. Various empirical evidence structural magnetic resonance imaging (MRI) studies has reported differences in grey matter (GM) among pediatric patients. However, some findings diverge others, association between GM individual remains inconclusive. To address this gap, we conducted a meta-analysis to synthesize quantitatively. current research quantitative voxel-based elucidate existence correlates OCD. A whole brain-based d-mapping approach was utilized explore changes further analyze relationship Thirteen were included with 288 patients 273 controls. Compared controls, demonstrated significantly greater volume left insula (SDM value = 1.72, p < 0.005) superior frontal gyrus (SFG) (orbital part) 1.47, 0.005), whereas showed lower right temporal (STG) -1.87, inferior parietal gyri (IPG) -1.60, middle occipital (MOG) -1.66, (IFG) -1.69, 0.005). increase SFG decrease IPG found those without psychiatric comorbidities treatment-naive subgroup. Meta-regression analysis revealed that longer duration associated less -3.057, Finally, age symptoms severity positively z 2.387, Our confirmed consistent OCD, particularly MOG, part), suggesting they are potential markers Larger smaller volumes specific untreated symptom also influence structure. This provides neuroanatomical characteristics PROSPERO CRD42024601906.

Language: Английский

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Patterns, Predictors, and Effectiveness of TMS for Treatment-Resistant OCD: A Naturalistic Study

Transcranial magnetic stimulation ., Journal Year: 2025, Volume and Issue: unknown, P. 100096 - 100096

Published: April 1, 2025

Language: Английский

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How did Johann Christian Reil feel the insular cortex? Gemeingefühl as a seat of mind

Journal of the History of the Neurosciences, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 12, 2025

Johann Christian Reil was the first to coin term "psychiatry" in 1808, prior that he had proposed Gemeingefühl (coenaesthesis), which is interpreted as referring integrated information of all senses and emotions. On other hand, 1809, formally described insular cortex die Insel considered serve pedestal mental activity. The background Reil's research been social, religious, cultural, political context social upheaval Europe at time, particularly Germany France, a major impact on academic medical systems advocated. For over 200 years, relationship between has remained mystery. However, recent neuroimaging studies are beginning shed light function cortex. This article provides an overview life reported date summarizes achievements medicine from perspectives physiology, neuroanatomy, psychiatry. Furthermore, we by relation gemeinsinn (sensus communis) common sense, provide perspective role seat mind, society culture.

Language: Английский

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Past, present, and future of deep transcranial magnetic stimulation: A review in psychiatric and neurological disorders

World Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 13(9), P. 607 - 619

Published: Sept. 15, 2023

Deep transcranial magnetic stimulation (DTMS) is a new non-invasive neuromodulation technique based on repetitive tech-nology. The H-coil has significant advantages in the treatment and mechanism research of psychiatric neurological disorders. This due to its deep site wide range action. paper reviews clinical progress DTMS disorders such as Parkinson's disease, Alzheimer's post-stroke motor dysfunction, aphasia, other disorders, well anxiety, depression, schizophrenia.

Language: Английский

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A predictive study of the efficacy of transcutaneous auricular vagus nerve stimulation in the treatment of major depressive disorder: an fMRI-based machine learning analysis

Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 98, P. 104079 - 104079

Published: May 28, 2024

In order to improve taVNS efficacy, the usage of fMRI explore predictive neuroimaging markers would be beneficial for screening appropriate MDD population before treatment.

Language: Английский

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Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Background Previous studies based on resting-state functional magnetic resonance imaging(rs-fMRI) and voxel-based morphometry (VBM) have demonstrated significant abnormalities in brain structure activity patients with early-onset schizophrenia (EOS), compared healthy controls (HCs), these alterations were closely related to the pathogenesis of EOS. However, previous suffer from limitations small sample sizes high heterogeneity results. Therefore, present study aimed effectively integrate identify common specific structural Methods The PubMed, Web Science, Embase, Chinese National Knowledge Infrastructure (CNKI), WanFang databases systematically searched publications regional gray matter volume (GMV) Then, we utilized Seed-based d Mapping Permutation Subject Images (SDM-PSI) software conduct a whole-brain voxel meta-analysis VBM rs-fMRI studies, respectively, followed by multimodal overlapping this basis comprehensively Results A total 27 original (28 datasets) included meta-analysis, including 12 (13 (496 EOS patients, 395 HCs) 15 (15 GMV (458 531 HCs). Overall, showed significantly increased left middle frontal gyrus (extending triangular part inferior gyrus) right caudate nucleus. On other hand, decreased superior temporal rolandic operculum), gyrus, pole (superior gyrus). Conclusion This revealed that some regions exhibited or abnormalities, such as gyri, prefrontal cortex, striatum. These findings may help deepen our understanding underlying pathophysiological mechanisms provide potential biomarkers for diagnosis treatment

Language: Английский

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Association between segmental alterations of white matter bundles and cognitive performance in first-episode, treatment-naïve young adults with major depressive disorder

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 309 - 317

Published: May 3, 2024

Language: Английский

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