Aerobic exercise therapy in severe mental disorders: from methods to underlying mechanisms

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

Mortality in patients with major depressive disorder: A nationwide population-based cohort study with 11-year follow-up

European Psychiatry, Journal Year: 2024, Volume and Issue: 67(1)

Published: Jan. 1, 2024

Abstract Background Major depressive disorder (MDD) is a leading cause of disability and premature mortality. This study compared the overall survival (OS) between patients with MDD non-MDD controls stratified by gender, age, comorbidities. Methods nationwide population-based cohort utilized longitudinal patient data (01/01/2010 – 12/31/2020) from Hungarian National Health Insurance Fund database, which contains healthcare service for population. Patients were selected matched 1:1 to those without using exact matching. The rates conversion bipolar (BD) or schizophrenia also investigated. Results Overall, 471,773 included in each groups. had significantly worse OS than (hazard ratio [HR] = 1.50; 95% CI: 1.48−1.51; males HR 1.69, 1.66–1.72; females 1.40, 1.38–1.42). estimated life expectancy was 7.8 6.0 years less that aged 20 45 years, respectively. Adjusted analyses based on presence baseline comorbidities showed (adjusted 1.29, 1.28–1.31). After 11 follow-up, cumulative conversions BD 6.8 3.4%, Converted non-converted patients. Conclusions Compared controls, higher mortality rate MDD, especially and/or who have converted schizophrenia, suggests early detection personalized treatment may reduce diagnosed MDD.

Language: Английский

Mortality among older people with late-onset and non-late-onset schizophrenia: A 5-year prospective multicenter study

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 274, P. 393 - 395

Published: Oct. 31, 2024

Language: Английский