Published: Dec. 9, 2024
Language: Английский
Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16
Published: Jan. 17, 2025
Suicide continues to be a significant public health issue globally, claiming over 700,000 lives annually. It is, therefore, important assess the suicide risk properly and provide intervention in timely fashion. While heritability of suicidal behavior is around 50%, it does not explain factors involved causality. Recent evidence suggests that gene x environment interaction plays vital role behavior. In this paper, we critically evaluate association between adolescent epigenetic modifications, including DNA methylation, histone modification, non-coding RNAs, as well epigenetic-based treatment options. was noted prevalence adolescents varied by age sex presence psychiatric disorders. Childhood adversity closely associated with Studies show alterations modifications may increase independent mental illnesses. Because are reversible, environmental enrichment or use pharmacological agents can target specific modulation able reduce population.
Language: Английский
Citations
1
NeuroImage, Journal Year: 2024, Volume and Issue: 292, P. 120589 - 120589
Published: April 1, 2024
Child maltreatment can adversely affect brain development, leading to vulnerabilities in structure and function various psychiatric disorders. Among the types of child maltreatment, neglect has highest incidence rate (76.0%); however, data on its sole adverse influence remain limited. This case-control magnetic resonance imaging (MRI) study identified changes gray matter that distinguish neglected children with no other type (Neglect group, n = 23) from typically developing (TD 140), investigated association between these structural functional differences specific psychosocial phenotypes observed children. Our results showed Neglect group had a larger right left anterior cingulate cortex (R/L.ACC) smaller angular gyrus (L.AG) volume. The R/L.ACC was associated hyperactivity inattention. Resting-state analysis increased connectivity (FC) supramarginal (L.SMG) salience network (SN) middle frontal (R.MFG) simultaneously decrease FC L.ACC for same seed. R.MFG difficulty peer problems depressive symptoms; mediating effect evident symptoms. These suggest atypicality indirectly contributes disturbed FCs within SN, thereby exacerbating symptoms In conclusion, exposure childhood may lead maladaptive particularly neural
Language: Английский
Citations
8
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Citations
0
Current Psychology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Language: Английский
Citations
0
American Journal of Preventive Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
This study examined the associations of adverse childhood experiences (ACEs) with falls and fall risk factors investigated whether mediate association between ACEs falls. population-based cross-sectional included 9,961 participants aged ≥45 years from 2014 Life History Survey 2015 follow-up survey China Health Retirement Longitudinal Study. Data analysis was performed April 3 to May 7, 2024. Logistic regression models were used assess cumulative number factors, as well each ACE type. The Karlson-Holm-Breen method examine total (direct indirect) effect mediating type Associations specific observed. Seven 12 associated falls, including physical abuse, household mental illness, witnessed domestic violence, bullying, parental death, sibling disability. Corresponding factor patterns totally or partly mediated six types (excluding death) Pain depressive symptoms dominant contributors. factors. predominantly Early identification targeted treatment pain are critical for reducing incidence exposed individuals in later life.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 5, 2025
Understanding the intergenerational transmission of childhood maltreatment (CM) is crucial to prevent its perpetuation future generations. The literature has revealed parental empathy be a pivotal factor in this process. Parental ability comprehend and empathetically respond emotions mental states children; therefore, impairment may result challenges parenting, ultimately contributing CM. In study, we explored factors that undermine how they alter parenting practices, uncover process To investigate actual instances CM, comparative study was conducted between 13 mothers with history social interventions owing CM 42 control group. Path analysis performed examine trajectory from adverse experiences explore their correlations variables including affective cognitive empathy, depressive symptoms, styles. results showed specifically enhanced emotional domain Furthermore, heightened group influenced style mediated by symptoms. These provide important insights into context empathy.
Language: Английский
Citations
0
Pediatric Allergy and Immunology, Journal Year: 2025, Volume and Issue: 36(3)
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 174, P. 106180 - 106180
Published: April 29, 2025
Language: Английский
Citations
0