Casual associations between brain structure and sarcopenia: A large‐scale genetic correlation and mendelian randomization study

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

Abstract Sarcopenia presenting a critical challenge in population‐aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. aim this study is to explore casual association sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted estimate genetic correlations; MR then performed causal relationship Brain imaging‐derived phenotypes (BIDPs) three sarcopenia‐related traits: handgrip strength, walking pace, appendicular lean mass (ALM). main analyses were using inverse‐variance weighted method. Moreover, median MR–Egger as sensitivity analyses. Genetic 6.41% BIDPs ALM observed, 4.68% exhibited with 2.11% causally associated 2.04% showed ALM. Volume ventromedial hypothalamus increased odds strength (OR: 1.18, 95% CI: 1.02 1.37) 1.05, 1.01 1.09). Mean thickness G‐pariet‐inf‐Angular decreased 0.83, 0.70 0.97) pace 0.97, 0.93 0.99). As part forward influences sarcopenia, which may provide new perspectives for prevention offer valuable insights research on brain‐muscle axis.

Language: Английский

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Sarcopenia, frailty prevalence, and related factors in patients with stroke: A cross-sectional analytical study from Turkey

Journal of Back and Musculoskeletal Rehabilitation, Journal Year: 2024, Volume and Issue: 37(5), P. 1345 - 1354

Published: June 28, 2024

BACKGROUND: Sarcopenia and frailty may develop at varying rates depending on the metabolic, structural, functional changes in muscle structure after stroke. OBJECTIVE: To evaluate prevalence of sarcopenia patients with stroke affecting clinical parameters. METHODS: This was a cross-sectional analytical study. Twenty-six (49.1%) women 27 men (50.9%) an average age 60.2 ± 10.3 (median = 62) years were included physical performance, balance, mobility, we used 4-meter walk test (4-MWT), timed up go test, chair sit stand Berg Balance Scale (BBS). diagnosed according to Asian Working Group for 2019 criteria. The SARC-F scale sarcopenia. RESULTS: duration 21.6 18.2 months. Prefrailty present 14 (26.4%) patients, 34 (64.2%) two (3.8%) normal. detected 28 (52.8%) patients. According handgrip strength, low strength 17% (n= 9). In sarcopenic group, female sex (p= 0.005) more frequent, 4-MWT longer 0.003), results lower (p< 0.001), (CFS) higher fall risk compared BBS there HG 0.009), malnutrition scores (PNI, prognostic nutritional index, p< lymphocyte counts 0.037). EAT-10 dysphagia presence 0.026), 0.021) Nottingham Health Profile score 0.001) group. CONCLUSION: frequently chronic stroke, counts, mobility balance scores, it is associated poor factors including high disease severity, dysphagia, malnutrition, falling, quality life.

Language: Английский

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Surface Electrical Impedance Myography Detects Skeletal Muscle Atrophy in Aged Wildtype Zebrafish and Aged gpr27 Knockout Zebrafish

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 1938 - 1938

Published: July 7, 2023

Throughout a vertebrate organism’s lifespan, skeletal muscle mass and function progressively decline. This age-related condition is termed sarcopenia. In humans, sarcopenia associated with risk of falling, cardiovascular disease, all-cause mortality. As the world population ages, projected to reach 2 billion older adults worldwide in 2050, economic burden on healthcare system also increase considerably. Currently, there are no pharmacological treatments for sarcopenia, given long-term nature aging studies, high-throughput chemical screens impractical mammalian models. Zebrafish promising, up-and-coming model field that could fill this gap. Here, we developed surface electrical impedance myography (sEIM) platform assess health, quantitatively noninvasively, adult zebrafish (young, aged, genetic mutant animals). aged (~85% lifespan) as compared young (~20% lifespan), sEIM parameters (2 kHz phase angle, reactance, resistance) robustly detected atrophy (p < 0.000001, q = 0.000002; p 0.000004, 0.000006; 0.000867, 0.000683, respectively). Moreover, these same measurements exhibited strong correlations an established morphometric parameter (myofiber cross-sectional area), determined by histological-based analysis (r 0.831, × 10−12; r 0.6959, 10−8; 0.7220; 4 10−9, Finally, deletion gpr27, orphan G-protein coupled receptor (GPCR), exacerbated animals, evidenced both histology. conclusion, data here show EIM techniques can effectively discriminate between healthy sarcopenic well advanced atrophied gpr27 KO animals. studies how values correlate cell size across making it potentially possible utilize “virtual biopsy” noninvasively myofiber atrophy, valuable measure gerontology research.

Language: Английский

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Causality between sarcopenia and diabetic nephropathy: a bidirectional Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 22, 2023

Observational studies have shown that sarcopenia and diabetic nephropathy (DN), are closely related; however, the causal relationship is unclear. This study aims to address this issue using a bidirectional Mendelian randomization (MR) study. We data from genome-wide association including appendicular lean mass (n = 244,730), grip strength (right: n 461,089, left: 461026), walking speed 459,915), DN (3283 cases 181,704 controls) conduct MR First, we conducted Forward analysis evaluate causality of on risk genetic perspective with mass, strength, as exposure outcome. Then, exposure, performed Reverse determine whether impacted appendices. Finally, series sensitivity studies, such heterogeneity tests, pleiotropy evaluations, Leave-one-out analyses, were assess analysis's accuracy further. According forward analysis, genetically predicted decrease in associated an increased developing (inverse variance weighting[IVW]: odd ratio [OR] 0.863, 95% confidence interval [CI] 0.767-0.971; P 0.014). reverse results, decreased progressed (IVW: right β 0.003, CI: - 0.021 0.009, 5.116e-06; left 0.024 0.012, 7.035e-09). However, results other analyses not statistically different. Notably, our findings suggest between cannot be generalized. individual characteristic factors sarcopenia, reducing increases linked reduced strength. But overall, there no DN, because diagnosis determined by one these alone.

Language: Английский

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Causality between sarcopenia-related traits and major depressive disorder: A bi-directional, two-sample Mendelian randomized study

Medicine, Journal Year: 2023, Volume and Issue: 102(40), P. e35071 - e35071

Published: Oct. 6, 2023

Observational studies have demonstrated an association between sarcopenia and depression. However, these may be influenced by confounding factors, the causal relationship major depressive disorder (MDD) remains unclear. This study aimed to apply Mendelian randomization (MR) method address factors assess effect of on MDD. A two-way, two-sample MR was employed in this study. Instrumental variables genome-wide significance level were obtained from open large-scale summary data. analysis conducted using inverse variance weighted, MR-Egger, weighted median methods. The reliability results verified heterogeneity test, pleiotropy leave-one-out for sensitivity analysis. Grip strength (right-hand grip strength: odds ratio [OR] = 0.880, 95% confidence interval [CI] 0.786-0.987, P .027; left-hand OR 0.814, CI 0.725-0.913, < .001) usual walking pace (OR 0.673, 0.506-0.896, .007) exhibited a direct MDD had significant appendicular lean mass (β -0.065, -0.110, -0.019, .005). There sarcopenia-related traits Loss muscle strength, rather than skeletal mass, is correlated with increased risk Furthermore, individuals are more likely experience loss mass.

Language: Английский

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Sarcopenia and anti‐seizure medication response in juvenile myoclonic epilepsy

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(3)

Published: March 1, 2024

Abstract Introduction This study aimed to investigate the presence of sarcopenia in patients with juvenile myoclonic epilepsy (JME) and association between response anti‐seizure medication (ASM) JME. Methods We enrolled 42 JME healthy controls who underwent brain magnetic resonance imaging three‐dimensional T1‐weighted imaging. measured temporal muscle thickness (TMT), a radiographic marker for sarcopenia, using compared TMT analyzed it according ASM also performed receiver operating characteristic (ROC) curve analysis evaluate how well differentiated groups. Results The did not differ from that (9.630 vs. 9.956 mm, p = .306); however, poor responders had lower than good (9.109 10.104 .023). ROC revealed exhibited performance differentiating controls, an area under .570 ( .270), but responders, .700 .015). Conclusion controls; was reduced suggesting link can be used various neurological disorders.

Language: Английский

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Sarcopenia in subjects with Alzheimer’s disease: prevalence and comparison of agreement between EGWSOP1, EGWSOP2, and FNIH criteria

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 22, 2024

Abstract Background Sarcopenia is an age-related clinical syndrome characterized by the progressive loss of muscle mass and strength. It appears to be closely linked dementia, particularly Alzheimer’s disease (AD); however, its prevalence among AD patients remains unclear. In this study, we assessed differences in sarcopenia between non-demented individuals patients. Moreover, sex-specific explored diagnostic value Muscle Quality Index (MQI) for diagnosing Method Cross-sectional study including 145 with probable 51 older adults normal cognition. was diagnosed according criteria European Working Group on Older People (EWGSOP1 EWGSOP2) Foundation National Institutes Health (FNIH). The MQI computed as ratio handgrip strength skeletal mass. Results No significant difference observed controls. Prevalence ranged from 3.4 23.4% 2 11.8% controls, depending criteria. higher using EWGSOP1 decreased EWGSOP2 FNIH. males than females AD. lower controls (95%CI: − 0.23, 0.05, p < 0.001), but displayed poor accuracy identifying cases. Conclusions show comparable prevalence. when compared FNIH

Language: Английский

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Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Purpose Sarcopenia is the presence of low skeletal muscle quantity or quality. It associated with increased morbidity and mortality. Aortic arch calcification (AAC) a type vascular that can be easily detected using chest X-rays. AAC sarcopenia share common risk factors such as aging, inflammation, diabetes mellitus, chronic kidney disease. In this study, we investigated relationship between to evaluate whether X-rays used predict in daily clinical practice. Methods was assessed via simple X-ray. evaluated computed tomography imaging, which allows for calculation mass area (SMA) index (SMI). Correlation analysis multivariable models were assess sarcopenia. Results A total 340 patients included study (122 AAC, 218 without AAC). more frequent than those (38.5% vs 16.5%, p < 0.001). SMI also negatively correlated severity (r: -0.246, model, independently related age, glomerular filtration rate, [(OR = 1.077, 95% CI 1.034–1.120, 0.001), (OR 0.985, 0.975–0.996, 0.008), 1.812, 1.030–3.188, 0.03), respectively)]. Conclusion by might population.

Language: Английский

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Bidirectional Association between Sarcopenia and Depressive Symptoms among Chinese Middle- and Older-Aged Adults: Longitudinal Observational Study

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 593 - 593

Published: June 11, 2024

The study aimed to examine the bidirectional relationship between sarcopenia and depressive symptoms in a national, community-based cohort study, despite unclear temporal sequence demonstrated previously.

Language: Английский

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Effect of Sarcopenia on Functional Recovery in Acute Stroke Patients Admitted for Standard Rehabilitation Program

Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1716 - 1716

Published: Oct. 20, 2024

: Sarcopenia is a significant concern in stroke rehabilitation, with high prevalence reported acute patients. This study examines the effect of sarcopenia on rehabilitation outcomes

Language: Английский

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