Demystifying normal‐anion‐gap metabolic acidosis: pathophysiology, aetiology, evaluation and diagnosis DOI Creative Commons
Ritesh Bhandari, Adel Ekladious, Muhammad M Javaid

et al.

Internal Medicine Journal, Journal Year: 2024, Volume and Issue: 54(7), P. 1056 - 1065

Published: June 5, 2024

Normal-anion-gap metabolic acidosis (NAGMA) is a common but often under-recognised and poorly understood condition, especially by less-experienced clinicians. In adults, NAGMA might be an initial clue to more significant underlying pathology, such as autoimmune diseases, hypergammaglobulinemia or drug toxicities. However, identifying the aetiology can challenging due diverse processes involved in development of acidosis. A better understanding pathophysiology help treating physicians suspect evaluate condition early reach correct diagnosis. This article provides overview renal acid-base regulation, discusses pathophysiological developing framework for evaluation accurate

Language: Английский

The pathophysiology of distal renal tubular acidosis DOI
Carsten A. Wagner, Robert J. Unwin, Sergio Camilo Lopez-Garcia

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(6), P. 384 - 400

Published: April 4, 2023

Language: Английский

Citations

38

Dose-related effects of eugenol: exploring renal functionality and morphology in healthy Wistar rats DOI
Renner Philipe Rodrigues Carvalho,

Rosiany Vieira da Costa,

Isadora Ribeiro de Carvalho

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 196, P. 115244 - 115244

Published: Jan. 8, 2025

Language: Английский

Citations

1

PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells DOI
Thomas Verissimo,

Delal Dalga,

Grégoire Arnoux

et al.

AJP Renal Physiology, Journal Year: 2023, Volume and Issue: 324(6), P. F532 - F543

Published: April 27, 2023

Phosphoenolpyruvate carboxykinase 1 (PCK1) is highly expressed in the proximal tubule. We show here that this enzyme crucial for maintenance of normal tubular physiology, lactate, and glucose homeostasis. PCK1 a regulator acid-base balance ammoniagenesis. Preventing downregulation during renal injury improves function, rendering it an important target disease.

Language: Английский

Citations

23

Gluconeogenesis in the kidney: in health and in chronic kidney disease DOI Creative Commons

Delal Dalga,

Thomas Verissimo, Sophie de Seigneux

et al.

Clinical Kidney Journal, Journal Year: 2023, Volume and Issue: 16(8), P. 1249 - 1257

Published: March 14, 2023

ABSTRACT Chronic kidney disease (CKD) is a global health issue with increasing prevalence. Despite large improvements in current therapies, slowing CKD progression remains challenge. A better understanding of renal pathophysiology needed to offer new therapeutic targets. The role metabolism alterations and mitochondrial dysfunction tubular cells increasingly recognized progression. In proximal cells, associated switch from fatty acid oxidation glycolysis. Glucose synthesis through gluconeogenesis one the principal physiological functions kidney. Loss stage-dependent manner key feature contributes systemic possibly local metabolic complications. consequences observed may be related an accumulation precursors, such as glycogen, but also various enzymes. basic features their modifications during will reviewed. influence on described, well consequences. Finally, interventions discussed.

Language: Английский

Citations

18

Source Tracing of Kidney Injury via the Multispectral Fingerprint Identified by Machine Learning-Driven Surface-Enhanced Raman Spectroscopic Analysis DOI

Yanwen Zhuang,

Yu Ouyang,

Li Ding

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2622 - 2633

Published: May 3, 2024

Early diagnosis of drug-induced kidney injury (DIKI) is essential for clinical treatment and intervention. However, developing a reliable method to trace origins through retrospective studies remains challenge. In this study, we designed ordered fried-bun-shaped Au nanocone arrays (FBS NCAs) create microarray chips as surface-enhanced Raman scattering (SERS) analysis platform. Subsequently, the principal component (PCA)-two-layer nearest neighbor (TLNN) model was constructed identify analyze SERS spectra exosomes from renal induced by cisplatin gentamycin. The established PCA-TLNN successfully differentiated at different stages causes, capturing most significant spectral features distinguishing these variations. For induction times, accuracy reached 97.8% (cisplatin) 93.3% (gentamicin). caused agents, 100% (7 days) 96.7% (14 days). This study demonstrates that combination label-free exosome machine learning could serve an innovative strategy medical therapeutic

Language: Английский

Citations

9

Metabolic acidosis in chronic kidney disease: mere consequence or also culprit? DOI Creative Commons
Christian Kuhn, Nilufar Mohebbi, Alexander Ritter

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(4), P. 579 - 592

Published: Jan. 27, 2024

Abstract Metabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after transplantation. It occurs when net endogenous acid production exceeds excretion. While nephron loss with reduced ammoniagenesis the main cause of retention CKD patients, additional pathophysiological mechanisms are likely inflicted transplant recipients. Functional tubular damage by calcineurin inhibitors seems to play key role causing renal acidosis. Notably, experimental clinical studies over past decades have provided evidence that metabolic may not only be consequence but also driver disease. In acidosis, activation hormonal systems complement system resulting fibrosis been described. Further changes metabolism will contribute deeper understanding pathophysiology CKD. alkali supplementation case serum bicarbonate < 22 mmol/l has endorsed guidelines for many years slow functional decline, among other considerations, beneficial effects thresholds treatment lately under intense debate. This review article discusses this topic light most recent results trials assessing efficacy dietary pharmacological interventions patients.

Language: Английский

Citations

6

Dual-modality and Noninvasive Diagnostic of MNP–PEG–Mn Nanoprobe for Renal Fibrosis Based on Photoacoustic and Magnetic Resonance Imaging DOI
Yilin Yang, Tingting Li,

Wenyu Jing

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(10), P. 12797 - 12808

Published: March 3, 2023

To date, imaging-guided multimodality therapy is important to improve the accuracy of diagnosis renal fibrosis, and nanoplatforms for are gaining more attention. There many limitations deficiencies in clinical use early-stage multimodal imaging can contribute thoroughly provide in-detail information effective diagnosis. Melanin an endogenous biomaterial, we developed ultrasmall particle size melanin nanoprobe (MNP-PEG-Mn) based on photoacoustic (PA) magnetic resonance (MR) dual-modal imaging. MNP-PEG-Mn nanoprobe, with average diameter about 2.7 nm, be passively targeted accumulation kidney, it has excellent free radical scavenging antioxidant abilities without further exacerbating fibrosis. Using normal group signal as a control, results showed that MR (MAI) PA (PAI) signals reached strongest at 6 h when entered 7 day fibrosis via left vein tail end mice; however, strength gradient change were significantly weaker 28 than group. The phenomenon preliminarily indicates PAI/MRI dual-modality contrast medium candidate, outstanding ability application potential.

Language: Английский

Citations

13

Association between albumin corrected anion gap and all-cause mortality in critically ill patients with acute kidney injury: a retrospective study based on MIMIC-IV database DOI Creative Commons

Penghui Gao,

Jie Min, Lei Zhong

et al.

Renal Failure, Journal Year: 2023, Volume and Issue: 45(2)

Published: Nov. 17, 2023

Background The early identification of patients at high risk for acute kidney injury (AKI) with a poor prognosis is crucial to prevent complications and minimize mortality. This study sought investigate the association between albumin-corrected anion gap (ACAG) all-cause mortality among critically ill AKI.

Language: Английский

Citations

12

Mechanisms and physiological relevance of acid-base exchange in functional units of the kidney DOI Creative Commons
E. A. Gantsova, О. В. Серова, Polina Vishnyakova

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17316 - e17316

Published: April 29, 2024

This review discusses the importance of homeostasis with a particular emphasis on acid-base (AB) balance, crucial aspect pH regulation in living systems. Two primary organ systems correct deviations from standard balance: respiratory system via gas exchange and kidneys proton/bicarbonate secretion reabsorption. Focusing kidney functions, we describe complexity renal architecture its challenges for experimental research. We address specific roles different nephron segments (the proximal convoluted tubule, loop Henle distal tubule) homeostasis, while explaining physiological significance ion processes maintained by kidneys, particularly role bicarbonate ions (HCO 3 − ) as an essential buffer body. The will be interest to researchers fields physiology, biochemistry molecular biology, which builds strong foundation critically evaluates existing studies. Our helps identify gaps knowledge thoroughly understanding literature related homeostasis.

Language: Английский

Citations

5

Electrolytes and Acid-Base Disorders DOI

Shelly Sehgal,

Sachin Gupta,

Manish Kumar Mishra

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

5