How do valence and meaning interact? The contribution of semantic control DOI Open Access
Nicholas E. Souter,

Ariyana Reddy,

Jake Walker

et al.

Published: April 28, 2022

The hub-and-spoke model of semantic cognition proposes that conceptual representations in a heteromodal ‘hub’ interact with and emerge from modality-specific features or ‘spokes’, including valence (whether concept is positive negative), along visual auditory features. As result, congruency might facilitate our ability to link words conceptually. Semantic relatedness may similarly affect explicit judgements about valence. Moreover, conflict between meaning recruit control processes. Here we tested these predictions using two-alternative forced-choice tasks, which participants matched probe word one two possible target words, based on either global Experiment 1 examined timed responses healthy young adults, while 2 decision accuracy aphasia patients impaired controlled retrieval following left hemisphere stroke. Across both experiments, semantically-related targets facilitated matching, related distractors performance. Valence was also found decision-making. People showed matching had particular difficulty when were presented, suggesting the selective information relies Taken together, results are consistent hypothesis automatic access written affects processing valence, retrieved even this feature task-irrelevant, affecting efficiency judgements.

Language: Английский

Dissecting white matter pathways: A neuroanatomical approach DOI
Stephanie J. Forkel,

Cesare Bortolami,

Lilit Dulyan

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 397 - 421

Published: Jan. 1, 2025

Language: Английский

Citations

1
Predicting functional impairments with lesion‐derived disconnectome mapping: Validation in stroke patients with motor deficits DOI Creative Commons

Maedeh Khalilian,

Martine Roussel,

Olivier Godefroy

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 59(11), P. 3074 - 3092

Published: April 5, 2024

Focal structural damage to white matter tracts can result in functional deficits stroke patients. Traditional voxel-based lesion-symptom mapping is commonly used localize brain structures linked neurological deficits. Emerging evidence suggests that the impact of focal may extend beyond immediate lesion sites. In this study, we present a disconnectome approach based on support vector regression (SVR) identify and pathways associated with For clinical validation, utilized imaging data from 340 patients exhibiting motor A map was initially derived lesions for each patient. Bootstrap sampling then employed balance sample size between minority group right or left those without Subsequently, SVR analysis voxels (p < .005). Our disconnectome-based significantly outperformed alternative approaches identifying major within corticospinal upper-lower limb Bootstrapping increased sensitivity (80%-87%) deficits, minimum 32 235 mm

Language: Английский

Citations

6
White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma DOI
Alessandro Salvalaggio, Lorenzo Pini,

Matteo Gaiola

et al.

JAMA Neurology, Journal Year: 2023, Volume and Issue: 80(11), P. 1222 - 1222

Published: Sept. 25, 2023

The prognosis of overall survival (OS) in patients with glioblastoma (GBM) may depend on the underlying structural connectivity brain.To examine association between white matter tracts affected by GBM and patients' OS means a new tract density index (TDI).This prognostic study histopathologic diagnosis examined discovery cohort 112 who underwent surgery February 1, 2015, November 30, 2020 (follow-up to May 31, 2023), Italy 70 replicative (n = 70) September 2012, 2015 Germany. Statistical analyses were performed from June 2021, 2023. Thirteen 12 excluded sets, respectively, because magnetic resonance imaging artifacts.The encompassing GBM.Correlation, linear regression, Cox proportional hazards Kaplan-Meier, prediction analysis used assess TDI OS. Results compared common factors GBM, including age, performance status, O6-methylguanine-DNA methyltransferase methylation, extent surgery.In 99; mean [SD] 62.2 [11.5] years; 29 female [29.3%]; male [70.7%]), was significantly correlated (r -0.34; P < .001). This more stable other factors. showed significant regression pattern (Cox: hazard ratio, 0.28 [95% CI, 0.02-0.55; .04]; linear: t -2.366; .02). Kaplan-Meier stratification as having lower or higher based (log-rank test 4.52; .03). confirmed 58; 58.5 [11.1] years, 14 [24.1%]; 44 [75.9%]). High (24-month cutoff) low (18-month predicted computed (accuracy 87%).In this study, GBMs regions associated longer These findings indicate that is reliable presurgical outcome predictor be considered clinical trials practice. support framework which depends patient's brain organization.

Language: Английский

Citations

12
Post-Stroke Outcome prediction based on lesion-derived features DOI Creative Commons

Maedeh Khalilian,

Olivier Godefroy,

Martine Roussel

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103747 - 103747

Published: Jan. 1, 2025

Language: Английский

Citations

0
Late maturation of semantic control promotes conceptual development DOI Open Access
Rebecca L. Jackson, Matthew A. Lambon Ralph, Timothy T. Rogers

et al.

Published: March 18, 2025

Control processes underpinned by the prefrontal cortex are critical for generating task-appropriate behaviour across cognitive domains, yet this region develops extremely late. Traditionally, developmental pattern is considered negative but necessary. However, an alternative (yet perhaps complementary) view suggests that a period without control could support learning, particularly in semantic domain. Here, we exploit recent computational model to test formally whether late development of context-sensitive use conceptual knowledge, or ‘semantic control’, would promote concept acquisition. Simulations show maturation and anatomical connectivity conspire learning. Delayed speeds learning compromising representations, when connects intermediate layers. To assess also human children, conducted meta-analysis classic triadic matching task where participants decide which two options best matches third. Matching can be based on taxonomic thematic relations. When these conflict, must exert determine relation appropriate. Context-sensitivity later than knowledge with large increases between 3 6 years. Thus, protracted PFC leads delay acquiring processes, benefiting

Language: Английский

Citations

0
Late maturation of semantic control promotes conceptual development DOI Open Access
Rebecca L. Jackson, Matthew A. Lambon Ralph, Timothy T. Rogers

et al.

Published: March 18, 2025

Control processes underpinned by the prefrontal cortex are critical for generating task-appropriate behaviour across cognitive domains, yet this region develops extremely late. Traditionally, developmental pattern is considered negative but necessary. However, an alternative (yet perhaps complementary) view suggests that a period without control could support learning, particularly in semantic domain. Here, we exploit recent computational model to test formally whether late development of context-sensitive use conceptual knowledge, or ‘semantic control’, would promote concept acquisition. Simulations show maturation and anatomical connectivity conspire learning. Delayed speeds learning compromising representations, when connects intermediate layers. To assess also human children, conducted meta-analysis classic triadic matching task where participants decide which two options best matches third. Matching can be based on taxonomic thematic relations. When these conflict, must exert determine relation appropriate. Context-sensitivity later than knowledge with large increases between 3 6 years. Thus, protracted PFC leads delay acquiring processes, benefiting

Language: Английский

Citations

0
Longitudinal prediction of motor dysfunction after stroke: a disconnectome study DOI Creative Commons
Lilit Dulyan, Lia Talozzi, Valentina Pacella

et al.

Brain Structure and Function, Journal Year: 2022, Volume and Issue: 227(9), P. 3085 - 3098

Published: Nov. 5, 2022

Abstract Motricity is the most commonly affected ability after a stroke. While many clinical studies attempt to predict motor symptoms at different chronic time points stroke, longitudinal acute-to-chronic remain scarce. Taking advantage of recent advances in mapping brain disconnections, we outcomes 62 patients assessed longitudinally two weeks, three months, and one year their Results indicate that disconnection patterns accurately impairments. However, leading impairment differ between three-time left right These results were cross-validated using resampling techniques. In sum, demonstrated while some neuroplasticity mechanisms exist changing structure–function relationship, prevail when predicting

Language: Английский

Citations

18
Multimodal Radiomics Based on Lesion Connectome Predicts Stroke Prognosis DOI
Ning Wu, Wei Lü, Mingze Xu

et al.

Computer Methods and Programs in Biomedicine, Journal Year: 2025, Volume and Issue: 263, P. 108701 - 108701

Published: March 1, 2025

Language: Английский

Citations

0
Mapping the functional differentiation and interactions among the inferior, medial frontal and posterior temporal cortex in semantic control DOI Creative Commons
Jiaxuan Liu, Xiuyi Wang, Hanqing Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Semantic control refers to the ability flexibly retrieve and manipulate stored knowledge support context-appropriate behavior. A left-lateralized network comprising left inferior frontal gyrus (IFG), posterior middle temporal (pMTG), dorsal medial prefrontal cortex (dmPFC) has been consistently implicated in this process. While previous studies have established necessity of IFG pMTG semantic control, causal role dmPFC remains unclear. Additionally, it is unknown whether each these three regions exhibits internal functional differentiation how they interact control. To address questions, we combined task-based magnetic resonance imaging (fMRI) with fMRI-guided transcranial stimulation (TMS). We found that dmPFC, like pMTG, causally involved All exhibited a consistent anterior–posterior gradient: anterior subregions were selectively engaged during high-demand processing, whereas responded both easy hard tasks. Furthermore, activation patterns better predicted behavioral differences between tasks compared any single region. modulated autoinhibition within individual connectivity among them, suggesting operate coordinated rather than isolation. These findings advance our understanding neural architecture supporting flexible Significance Statement Understanding brain supports behavior critical for cognitive neuroscience clinical neuropsychology. prior IFG, contribution dynamics remained This study provides first evidence dmPFC’s reveals shows as an integrated network. challenge notion functionally homogeneous nodes highlight topographically organized, interactive system underlying controlled retrieval. work refines mechanistic may inform models language conceptual deficits.

Language: Английский

Citations

0
Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke DOI Creative Commons
Julian Klingbeil, Max-Lennart Brandt, Anika Stockert

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: May 17, 2023

Introduction Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological biological factors. Lesion location a readily available information in stroke patients, it unclear if the neurobiological substrates of PSDS spatially localized. Building on previous analyses, we sought to determine associated with specific lesion locations, structural disconnection and/or localized functional diaschisis. Methods In prospective observational study, examined 270 patients first-ever Hospital Anxiety Depression Scale (HADS) around 6 months post-stroke. Based individual locations depression subscale HADS performed support vector regression lesion-symptom mapping, structural-disconnection-symptom mapping network-symptom-mapping, reanalysis this previously published cohort infer structure–function relationships. Results We found that were (i) lesions right insula, putamen, inferior frontal gyrus amygdala (ii) temporal lobe. contrast, no association addition, unable confirm described between symptom load network damage score derived from maps. Discussion our results, other recent studies, see growing evidence prominent role frontostriatal brain circuits PSDS.

Language: Английский

Citations

9