International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15978 - 15978
Published: Nov. 5, 2023
A
template-assisted
assembly
approach
to
a
C24
fullerene-like
double-stranded
DNA
polyhedral
shell
is
proposed.
The
employed
supramolecular
oligonucleotide
dendrimer
as
3D
template
that
was
obtained
via
the
hybridization
of
siRNA
strands
and
single-stranded
joined
three-
or
four-way
branched
junctions.
building
block
(a
starlet)
designed
for
composed
three
identical
self-complementary
single
RNA
strand
oligonucleotides
template.
To
prevent
premature
auto-hybridization
in
starlet,
photolabile
protecting
group
introduced
N3-substituted
thymidine
phosphoramidite.
Cleavable
linkers
such
disulfide
linkage,
RNase
sensitive
triribonucleotides,
di-
trideoxynucleotides
were
incorporated
into
starlet
at
specific
points
guide
post-assembly
disconnection
from
template,
enzymatic
disassembly
biological
media.
At
same
time,
modified
with
2′-OMe
ribonucleotides
phosphorothioate
groups
certain
positions
stabilize
toward
digestion.
We
report
herein
solid-phase
synthesis
oligodeoxy
oligoribonucleotide
blocks
DNA/RNA
dendritic
construction
after
initial
molecular
modeling,
followed
by
around
DNA-coated
visualization
resulting
nanostructure
transmission
electron
microscopy.
Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
24(5), P. 1419 - 1440
Published: Jan. 1, 2024
Although
developed
independently
at
the
beginning,
AI,
micro/nanorobots
and
microfluidics
have
become
more
intertwined
in
past
few
years
which
has
greatly
propelled
cutting-edge
development
fields
of
biomedical
sciences.
BioMed Research International,
Journal Year:
2023,
Volume and Issue:
2023(1)
Published: Jan. 1, 2023
Numerous
disorders
go
untreated
owing
to
a
lack
of
suitable
drug
delivery
technology
or
an
appropriate
therapeutic
moiety,
particularly
when
toxicities
and
side
effects
are
major
concern.
Treatment
options
for
microbiological
infections
not
fulfilled
significant
adverse
extended
options.
Advanced
therapy
options,
such
as
active
targeting,
may
be
preferable
traditional
ways
treating
infectious
diseases.
Niosomes
can
defined
microscopic
lamellar
molecules
formed
by
mixture
cholesterol,
nonionic
surfactants
(alkyl
dialkyl
polyglycerol
ethers),
sometimes
charge-inducing
agents.
These
comprise
both
hydrophilic
hydrophobic
moieties
varying
solubilities.
In
this
review,
several
pathogenic
microbes
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Klebsiella
pneumoniae,
Plasmodium,
Leishmania,
Candida
spp.
have
been
evaluated.
Also,
the
development
proper
niosomal
formulation
required
application
was
discussed.
This
review
also
reviews
that
optimal
is
dependent
on
aspects,
including
choice
surfactant,
fabrication
process,
parameters.
Finally,
will
give
information
effectiveness
niosomes
in
acute
microbial
infections,
mechanism
action
combating
pathogens,
advantages
using
over
other
treatment
modalities.
Abstract
The
zinc
oxide‐silver
oxide
nanocomposite
(ZnO.Ag
2
O
3
particles)
was
prepared
by
using
an
aqueous
plant
extract
of
Haplophyllum
obtusifolium
for
the
first
time.
Powder
X‐ray
diffraction
(PXRD),
Fourier
transforms
spectroscopy
(FTIR),
field
emission
microscopy
(FESEM),
energy
dispersive
analysis
(EDX),
and
transmission
electron
(TEM)
were
applied
to
analyze
structure,
functional
groups,
morphology,
purity
nanocomposite.
PXRD
revealed
formulation
ZnO.Ag
particles.
investigation
groups
has
demonstrated
presence
some
carbonated
impurities
along
with
absorbed
water
in
composition
Morphologically,
particles
have
formed
a
petal‐like
shape
different
sizes.
EDX
also
confirmed
sample
4.78%
silver
formula.
Additionally,
TEM
spherical
rectangular
shapes
particle
size
80.43
±
46.73
nm.
Moreover,
used
against
cancer
cells,
which
shown
synthesized
NCs
toxic
effect
liver
cells
concentration
time‐dependent
manner.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 15, 2023
Nanoconstructs
are
made
up
of
nanoparticles
and
ligands,
which
can
deliver
the
loaded
cargo
at
desired
site
action.
Various
nanoparticulate
platforms
have
been
utilized
for
preparation
nanoconstructs,
may
serve
both
diagnostic
as
well
therapeutic
purposes.
mostly
used
to
overcome
limitations
cancer
therapies,
such
toxicity,
nonspecific
distribution
drug,
uncontrolled
release
rate.
The
strategies
employed
during
design
nanoconstructs
help
improve
efficiency
specificity
theranostic
agents
make
them
a
successful
approach
therapy.
designed
with
sole
purpose
targeting
requisite
site,
overcoming
barriers
hinders
its
right
placement
benefit.
Therefore,
instead
classifying
modes
delivery
actively
or
passively
targeted
systems,
they
suitably
classified
autonomous
nonautonomous
types.
At
large,
offer
numerous
benefits,
however
suffer
from
multiple
challenges,
too.
Hence,
challenges
computational
modelling
methods
artificial
intelligence/machine
learning
processes
being
explored.
current
review
provides
an
overview
on
attributes
applications
offered
by
agent
in
cancer.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e19659 - e19659
Published: Aug. 31, 2023
In
this
research,
zinc
oxide
(ZnO)
nanoparticles
doped
with
different
percentages
of
produced
cobalt
using
the
green
synthesis
method.
ZnO
showed
good
cellular
and
microbial
toxicity
due
to
their
high
surface-to-volume
ratio.
Adding
metal
nanostructure
can
lead
appearance
a
new
feature.
To
investigate
effect
adding
metal,
synthesized
containing
3
6%
were
plant
extract.
The
resulting
nanostructures
characterized
by
Raman
spectroscopy,
UV–Visible
spectrometer,
X-ray
diffraction,
Field
emission
scanning
electron
microscopy.
Ultimately,
samples'
cytotoxicity
antimicrobial
tests
performed.
XRD
confirmed
formation
hexagonal
wurtzite
structure.
imaging
that
doping
resulted
in
decrease
average
crystal
size.
results
doping,
particle
size
decreased
slightly.
effects
all
three
studies,
leads
an
increase
compared
non-doped
nanoparticles.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
16(6), P. 2713 - 2746
Published: Dec. 7, 2023
Nanoniosome-based
drug
codelivery
systems
have
become
popular
therapeutic
instruments,
demonstrating
tremendous
promise
in
cancer
therapy,
infection
treatment,
and
other
domains.
An
emerging
form
of
vesicular
nanocarriers,
niosomes
are
self-assembling
vesicles
composed
nonionic
surfactants,
along
with
cholesterol
or
amphiphilic
molecules.
This
comprehensive
review
focuses
on
how
nanosystems
may
aid
making
anticancer
antibacterial
pharmaceuticals
more
stable
soluble.
As
malleable
nanodelivery
the
composition,
types,
preparation
procedures,
variables
affecting
structure
stability
extensively
investigated.
In
addition,
advantages
dual
for
combination
therapy
administration
multiple
medications
simultaneously
highlighted.
Along
categorizing
niosomal
delivery
systems,
a
analysis
various
techniques,
including
thin-layer
injection,
ether
microfluidization,
is
provided.
Dual
treatment
discussed
detail
regarding
two
organic,
plant-based
bioactive
compounds
gene
agents.
niogelosomes
metallic
carriers
targeted
distribution
discussed.
The
also
investigates
simultaneous
substances
agents,
siRNA,
microRNA,
shRNA,
lncRNA,
DNA.
Additional
sections
discuss
use
cutaneous
treating
leishmanial
infections,
Microscopy Research and Technique,
Journal Year:
2023,
Volume and Issue:
87(2), P. 272 - 278
Published: Sept. 28, 2023
Abstract
The
nanostructures
have
the
great
potential
for
novel
medical
and
drug
delivery
applications.
In
present
paper
a
green
approach
preparation
of
pure
nickel
oxide
(NiO)
5%
cobalt‐doped
NiO
(Co╫NiO)
nanoparticles
(NPs)
by
using
Prosopis
fracta
extract
been
study.
product
Co╫NiO
NPs
was
proved
through
PXRD,
Raman,
UV–Vis,
FESEM,
EDX
analyses.
results
XRD,
EDX,
UV–Visible
spectra
displayed
well
doped
cobalt
in
NP.
particle
sizes
were
observed
to
be
about
80
nm.
MTT
test
cytotoxicity
on
breast
cancer
cells
(MCF‐7)
affirmed
stronger
impact
NiO‐NPs
compared
NPs.
Thus,
it
is
indicated
that
doping
process
caused
an
increase
its
inhibitory
effect
against
MCF‐7
cells.
Research
Highlights
Cobalt‐doped
prepared
ecofriendly
synthesis
method
their
studied
