Biology,
Journal Year:
2024,
Volume and Issue:
13(8), P. 581 - 581
Published: July 31, 2024
Liposomes
and
niosomes
can
be
considered
excellent
drug
delivery
systems
due
to
their
ability
load
all
compounds,
whether
hydrophobic
or
hydrophilic.
In
addition,
they
reduce
the
toxicity
of
loaded
without
reducing
its
effectiveness.
Synechocystis
sp.
is
a
unicellular,
freshwater
cyanobacteria
strain
that
contains
many
bioactive
compounds
qualify
use
in
industrial,
pharmaceutical,
other
fields.
This
study
investigated
potential
nano-liposomes
(L)
nano-niosomes
(N)
for
delivering
extract
against
cancer
cell
lines.
Four
different
types
nanoparticles
were
prepared
using
dry
powder
formulation
ethanol
both
nanovesicles
(N1
N2,
respectively)
liposomes
(L1
L2,
respectively).
Analysis
formed
vesicles
zeta
analysis,
SEM
morphological
visual
examination
confirmed
stability
efficiency.
L1
L2
this
investigation
had
effective
diameters
419
847
nm,
respectively,
with
PDI
values
0.24
0.27.
Furthermore,
potentials
found
range
from
−31.6
mV
−43.7
mV.
Regarding
N1
541
nm
1051
0.31
0.35,
reported
−22.2
mV,
respectively.
Metabolic
profiling
tentatively
identified
22
metabolites
(1–22)
ethanolic
extract.
Its
effect
representative
human
cancers
was
studied
vitro,
specifically
colon
(Caco2),
ovarian
(OVCAR4),
breast
(MCF7)
The
results
showed
activities
N1,
L1,
three
lines,
where
cytotoxicity
IC50
19.56,
33.52,
9.24
µg/mL
compared
26.27,
56.23,
19.61
Caco2,
OVCAR4,
MCF7,
On
hand,
exhibited
9.09,
11.42,
2.38
µg/mL,
while
N2
15.57,
18.17,
35.31
Meanwhile,
formulations
little
on
normal
lines
(FHC,
OCE1,
MCF10a).
All
evaluated
silico
epidermal
growth
factor
receptor
tyrosine
kinase
(EGFR).
molecular
docking
compound
21
(1-hexadecanoyl-2-(9Z-hexadecenoyl)-3-(6′-sulfo-alpha-D-quinovosyl)-sn-glycerol),
followed
by
6
(Sulfoquinovosyl
monoacylgycerol),
7
(3-Hydroxymyristic
acid),
8
(Glycolipid
PF2),
12
(Palmitoleic
19
(Glyceryl
monostearate),
highest
binding
affinities.
These
good
hydrogen
bond
interactions
key
amino
acid
Lys721
as
co-crystallized
ligand.
suggest
hold
promise
future
treatment
development.
Further
research
should
focus
clinical
trials,
assessments,
pharmacological
profiles
translate
approach
into
anticancer
drugs.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 223 - 223
Published: Feb. 4, 2024
Niosomes
are
vesicular
nanocarriers,
biodegradable,
relatively
non-toxic,
stable,
and
inexpensive,
that
provide
an
alternative
for
lipid-solid
carriers
(e.g.,
liposomes).
may
resolve
issues
related
to
the
instability,
fast
degradation,
bioavailability,
insolubility
of
different
drugs
or
natural
compounds.
can
be
very
efficient
potential
systems
specific
delivery
anticancer,
antioxidant,
anti-inflammatory,
antimicrobial,
antibacterial
molecules.
This
review
aims
present
overview
their
composition,
most
common
formulation
techniques,
as
well
recent
utilizations
in
cancer
therapy.
Biological Procedures Online,
Journal Year:
2023,
Volume and Issue:
25(1)
Published: Nov. 9, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nanoscale
derived
from
cells
that
mediate
intercellular
communication
by
transporting
bioactive
molecules.
They
play
significant
roles
in
various
physiological
and
pathological
conditions.
EVs
hold
great
potential
as
novel
biomarkers
of
diseases,
therapeutic
agents,
drug
delivery
vehicles.
Furthermore,
vehicles
have
demonstrated
advantages
preclinical
settings.
In
this
review,
we
discussed
the
biogenesis
characteristics
their
functions
cancer.
We
summarize
applications
a
natural
cancer
therapy.
highlight
existing
challenges,
illuminate
vital
questions,
propose
recommendations
to
effectively
address
them
effectively.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(8), P. 3881 - 3914
Published: Jan. 1, 2024
The
long
noncoding
RNAs
(lncRNAs)
comprise
a
wide
range
of
RNA
species
whose
length
exceeds
200
nucleotides,
which
regulate
the
expression
genes
and
cellular
functions
in
organisms.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(9), P. 105086 - 105086
Published: June 16, 2023
Ifosfamide
(IFO)
is
a
member
of
the
oxazaphosphorine
family
alkylating
drugs
that
exhibits
anticancer
and
immunoregulatory
properties.
The
toxicity
IFO
dose-limited
because
its
biotransformation
into
highly
reactive
metabolites,
including
acrolein
chloroacetaldehyde.
Here,
we
aimed
to
design
novel
niosomal
formulations
encapsulate
within
niosomes
assess
efficacy
nanoformulation
via
conducting
in
vivo,
vitro,
silico
analyses.
Niosomal
showed
monodisperse
size
distribution
with
an
average
97
nm.
In
addition,
transmission
electron
microscopy
(TEM)
revealed
spherical
morphology
high
stability
no
aggregation.
On
other
hand,
(0.01–100
µg/mL)
cytotoxicity
against
breast
cancer
(MCF7)
neuroblastoma
(SH-SY5Y)
cells
concentration-dependent
fashion.
IFO-loaded
had
lower
IC50s
cancerous
cell
lines
than
standard
IFO,
most
pronounced
being
SH-SY5Y
(IC50
=
0.184
µg/mL).
Intravenous
treatments
rats
at
0.1
mg/kg
body
weight
(bw)
0.2
bw
significantly
increased
biochemical
parameters
such
as
blood
urea
nitrogen
(BUN),
creatinine
(CR),
alanine
aminotransferase
(ALT),
aspartate
(AST).
Moreover,
doses
caused
obvious
changes
liver
tissue.
Both
free
histopathological
lesions
parameters.
calculations
interaction
through
oxygen
connected
phosphor
atom
head
group
Span
60
tween
60.
For
first
time,
designed
well-characterized
formulation
for
targeted
delivery
IFO.
Our
exhibited
optimum
desirable
activity
can
be
considered
suitable
carrier
potential
future
usage
controlled
release
chemotherapeutics;
however,
more
studies
are
needed
safety
towards
normal
human
cells.
Pharmaceutical Nanotechnology,
Journal Year:
2023,
Volume and Issue:
12(3), P. 206 - 228
Published: July 27, 2023
Over
the
past
few
decades,
advancements
in
nanocarrier-based
therapeutic
delivery
have
been
significant,
and
niosomes
research
has
recently
received
much
interest.
The
self-assembled
nonionic
surfactant
vesicles
lead
to
production
of
niosomes.
most
recent
nanocarriers,
niosomes,
are
made
surfactants
with
or
without
proper
quantities
cholesterol
other
amphiphilic
molecules.
Because
their
durability,
low
cost
components,
largescale
production,
simple
maintenance,
high
entrapment
efficiency,
being
used
more
frequently.
Additionally,
they
enhance
pharmacokinetics,
reduce
toxicity,
solubility
poorly
water-soluble
compounds,
&
increase
bioavailability.
One
crucial
features
is
controlled
release
targeted
diffusion,
which
utilized
for
treating
cancer,
infectious
diseases,
problems.
In
this
review
article,
we
covered
all
fundamental
information
about
including
preparation
techniques,
types,
factors
influencing
formation,
evaluation,
applications,
administration
routes,
along
developments.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
16(6), P. 2713 - 2746
Published: Dec. 7, 2023
Nanoniosome-based
drug
codelivery
systems
have
become
popular
therapeutic
instruments,
demonstrating
tremendous
promise
in
cancer
therapy,
infection
treatment,
and
other
domains.
An
emerging
form
of
vesicular
nanocarriers,
niosomes
are
self-assembling
vesicles
composed
nonionic
surfactants,
along
with
cholesterol
or
amphiphilic
molecules.
This
comprehensive
review
focuses
on
how
nanosystems
may
aid
making
anticancer
antibacterial
pharmaceuticals
more
stable
soluble.
As
malleable
nanodelivery
the
composition,
types,
preparation
procedures,
variables
affecting
structure
stability
extensively
investigated.
In
addition,
advantages
dual
for
combination
therapy
administration
multiple
medications
simultaneously
highlighted.
Along
categorizing
niosomal
delivery
systems,
a
analysis
various
techniques,
including
thin-layer
injection,
ether
microfluidization,
is
provided.
Dual
treatment
discussed
detail
regarding
two
organic,
plant-based
bioactive
compounds
gene
agents.
niogelosomes
metallic
carriers
targeted
distribution
discussed.
The
also
investigates
simultaneous
substances
agents,
siRNA,
microRNA,
shRNA,
lncRNA,
DNA.
Additional
sections
discuss
use
cutaneous
treating
leishmanial
infections,
