Probiotics and Antimicrobial Proteins,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 23, 2025
Abstract
Targeting
gut
microbiota
is
an
innovative
approach
to
mitigate
the
development
of
metabolic
dysfunction-associated
steatotic
liver
disease-associated
hepatocellular
carcinoma
(MASLD-HCC).
This
study
aims
investigate
effects
Prohep,
a
probiotic
mixture,
both
as
prophylactic
measure
and
adjuvant
therapy
for
low-dose
sorafenib.
A
MASLD-HCC
mice
model
was
established
by
diethylnitrosamine
(DEN)
injection
with
feeding
high-fat
high-cholesterol
(HFHC)
diet.
Gut
microbiome
profiles
were
later
identified
through
shotgun
sequencing.
Our
findings
demonstrated
that
Prohep
supplementation
effectively
suppressed
in
mice.
protective
effect
attributed
modulation
increased
production
short-chain
fatty
acids
(SCFAs),
propionate,
valerate.
also
activated
AMPK,
which
decreased
lipogenesis,
reduced
lipid
uptake,
enhanced
antioxidant
enzyme
expressions.
Additionally,
cancer
proliferation
pathway
PI3K/mTOR
inhibited
response
treatment.
As
therapy,
improved
efficacy
sorafenib,
indicated
tumor
counts,
alleviated
inflammation,
hepatic
superoxide
dismutase
(SOD)
expression.
The
combination
led
butyrate
production,
contributing
overall
therapeutic
effects,
thanks
modulatory
Prohep.
These
results
underscore
Prohep’s
anti-tumorigenic
properties
its
potential
enhance
outcomes
sorafenib
highlights
importance
developing
effective
neoadjuvant
therapies
long-term
management
strategies
MASLD-HCC.
International Journal of Food Sciences and Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 27
Published: Dec. 19, 2024
This
comprehensive
review
examines
the
impact
of
dietary
patterns
on
gut
microbiome
composition
and
diversity
from
infancy
to
old
age,
linking
these
changes
age-related
health
outcomes.
It
investigates
how
develops
across
life
stages,
focusing
influence
factors.
The
explores
early-life
feeding
practices,
including
breastfeeding
formula
feeding,
shape
infant
microbiota
have
lasting
effects.
In
elderly
individuals,
alterations
in
are
associated
with
increased
susceptibility
infections,
chronic
inflammation,
metabolic
disorders
cognitive
decline.
critical
role
diet
modulating
throughout
is
emphasised,
particularly
potential
benefits
probiotics
fortified
foods
promoting
healthy
ageing.
By
elucidating
mechanisms
connecting
food
systems
health,
this
provides
insights
into
interventions
that
could
enhance
resilience
improve
outcomes
lifespan.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(46), P. 14732 - 14743
Published: Nov. 9, 2022
The
sugar
moieties
of
natural
flavonoids
determine
their
absorption,
bioavailability,
and
bioactivity
in
humans.
To
explore
structure-dependent
bioactivities
quercetin,
isoquercetin,
rutin,
which
have
the
same
basic
skeleton
linking
different
moieties,
we
systemically
investigated
ameliorative
effects
dietary
these
on
high-fat
diet
(HFD)-induced
nonalcoholic
fatty
liver
disease
(NAFLD)
mice.
Our
results
revealed
that
isoquercetin
exhibits
strongest
capability
improving
NAFLD
phenotypes
mice,
including
body
weight
gain,
glucose
intolerance,
systemic
inflammation
comparison
with
quercetin
rutin.
At
molecular
level,
markedly
ameliorated
dysfunction
host
metabolic
disorders
mice
NAFLD.
microbial
three
compounds,
especially
can
effectively
regulate
gut
microbiota
composition,
such
as
genera
Akkermansia,
Bifidobacterium,
Lactobacillus,
were
significantly
disrupted
These
comparative
findings
offer
new
insights
into
activities
for
treatment.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: June 20, 2024
Abstract
Dietary
emulsifiers
are
linked
to
various
diseases.
The
recent
discovery
of
the
role
gut
microbiota–host
interactions
on
health
and
disease
warrants
safety
reassessment
dietary
through
lens
microbiota.
Lecithin,
sucrose
fatty
acid
esters,
carboxymethylcellulose
(CMC),
mono-
diglycerides
(MDG)
common
with
high
exposure
levels
in
population.
This
study
demonstrates
that
esters
induce
hyperglycemia
hyperinsulinemia
a
mouse
model.
CMC
disrupt
glucose
homeostasis
vitro
insulin-resistance
MDG
impairs
circulating
lipid
metabolism.
All
change
intestinal
microbiota
diversity
dysbiosis.
do
not
impact
mucus–bacterial
interactions,
whereas
tends
cause
bacterial
encroachment
into
inner
mucus
layer
enhance
inflammation
potential
by
raising
lipopolysaccharide.
Our
findings
demonstrate
concerns
associated
using
emulsifiers,
suggesting
they
could
lead
metabolic
syndromes.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 11, 2024
Abstract
Background
The
energy/protein
imbalance
in
a
low-protein
diet
induces
lipid
metabolism
disorders
late-phase
laying
hens.
Reducing
energy
levels
the
to
adjust
energy-to-protein
ratio
may
improve
fat
deposition,
but
this
also
decreases
performance
of
This
study
investigated
mechanism
by
which
different
influences
liver
hens
through
enterohepatic
axis
guide
feed
optimization
and
nutrition
strategies.
A
total
288
were
randomly
allocated
normal-energy
normal-protein
group
(positive
control:
CK)
or
1
3
groups:
low-energy
(LL),
(NL),
high-energy
(HL)
groups.
ratios
CK,
LL,
NL,
HL
diets
0.67,
0.74,
0.77,
0.80,
respectively.
Results
Compared
with
CK
group,
egg
quality
deteriorated
increasing
intake
fed
diet.
Hens
had
significantly
higher
triglyceride,
cholesterol,
acetyl-CoA
carboxylase,
fatty
acid
synthase
levels,
lower
hepatic
lipase
compared
group.
Liver
transcriptome
sequencing
revealed
that
genes
involved
beta-oxidation
(
ACOX1
,
HADHA
EHHADH
ACAA1
)
downregulated,
whereas
related
synthesis
SCD
FASN
ACACA
upregulated
LL
Comparison
cecal
microbiome
showed
an
diet,
Lactobacillus
Desulfovibrio
enriched,
riboflavin
was
suppressed.
Cecal
metabolites
most
affected
included
several
vitamins,
such
as
(vitamin
B
2
),
pantethine
5
derivative),
pyridoxine
6
4-pyridoxic
acid.
Conclusion
disorder
due
deficiencies
vitamin
originating
from
be
underlying
reason
for
accumulation
Based
on
present
study,
we
propose
targeting
derivative)
might
effective
strategy
improving
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(18), P. 6944 - 6955
Published: April 26, 2023
Diabetes
mellitus
is
a
serious,
chronic
disease
worldwide;
yet
it
largely
preventable
through
physical
activity
and
healthy
diets.
Ougan
(Citrus
reticulata
cv.
Suavissima)
characteristic
citrus
variety
rich
in
polymethoxyflavones.
In
the
present
study,
anti-diabetic
effects
of
polymethoxyflavone-enriched
fraction
from
(OG-PMFs)
were
investigated.
Diabetic
KK-Ay
mice
supplemented
with
different
doses
OG-PMFs
for
5
weeks.
Our
results
demonstrated
that
exhibited
robust
protective
against
diabetes
symptoms
mice.
The
potential
mechanisms
may
partially
be
attributed
to
restoration
hepatic
GLUT2
catalase
expression.
Notably,
OG-PMF
administration
significantly
altered
gut
microbiota
composition
diabetic
KK-Ay,
indicated
by
suppression
metabolic
disease-associated
genera
Desulfovibrio,
Lachnoclostridium,
Enterorhabdus,
Ralstonia,
implying
might
another
target
show
effects.
Taken
together,
our
provided
supplementation
metabolic-protective
PMFs
highlighted
hold
great
developed
as
functional
food
ingredient.
Journal of Research in Pharmacy,
Journal Year:
2025,
Volume and Issue:
29(1), P. 310 - 321
Published: March 3, 2025
Mentawai
taro
(Colocasia
esculenta
var.
Mentawai,
Araceae)
corm
is
a
staple
food
for
local
people
in
islands,
West
Sumatra,
Indonesia.
This
study
aimed
to
determine
whether
the
incorporation
of
fiber
and
starch
extracted
from
could
improve
adiposity
plasma
lipid
profiles
intestinal
microbiota
composition
mice
fed
fatty
diet.
Adult
male
(n
=
24)
were
assigned
four
groups
diet
treatments:
normal
(ND),
high-fat
(HFD),
HFD
supplemented
with
20%
or
corm,
respectively.
After
12-week
treatment,
body
weight,
adipose
tissues,
investigated.
The
results
showed
that
was
capable
substantially
preventing
excessive
weight
increase
against
HFD.
Moreover,
significantly
suppress
white
tissue
mass
adipocyte
hypertrophy
while
reduction
brown
hypertrophy.
also
effectively
reduce
total
cholesterol,
low-density
lipoprotein-cholesterol,
triglyceride
levels.
result
indicated
modulate
diversity
by
promoting
health
beneficial
taxa
suppressing
pathogenic
taxa.
Overall,
effectivity
managing
detrimental
effects
outperformed
corm.
Hence,
it
be
recommended
as
potent
supplement
combat
diet-induced
metabolic
problems,
particularly
obesity,
dyslipidemia,
gut
dysbiosis.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 5, 2025
Immune
dysregulation-induced
inflammation
serves
as
a
driving
force
in
the
progression
of
metabolic
dysfunction-associated
steatohepatitis
(MASH),
while
underlying
cellular
and
molecular
mechanisms
remain
largely
uncharted.
A
Western
diet
(WD)
is
employed
to
construct
mouse
models
dysfunction
associated
steatotic
liver
disease
(MASLD)
or
MASH.
Mass
cytometry
identifies
c-kit+
cDC1
subset
whose
frequency
reduced
livers
mice
patients
with
MASH
compared
healthy
controls.
Adoptive
cell
transfer
protects
Moreover,
analysis
gut
microbe
sequence
shows
that
WD-fed
MASLD/MASH
exhibit
microbiota
dysbiosis,
an
elevated
abundance
H2S-producing
Desulfovibrio_sp.
Transplanting
MASH-derived
fecal
flora,
Desulfovibrio_sp.,
injecting
H2S
intraperitoneally
into
MASLD
decreases
c-kit+cDC1
population
exacerbates
inflammation.
Mechanistically,
induces
autophagic
death
c-kit-dependent
manner
cDC-specific
c-kit-/-
Atg5-/-
mice.
We
thus
uncover
microbiota-derived
triggers
ignites
inflammatory
cascade
Cell Reports,
Journal Year:
2025,
Volume and Issue:
44(3), P. 115424 - 115424
Published: March 1, 2025
Highlights•Moderate
exercise
enhances
gut
colonization
resistance
against
MRSA
in
mice•D.
newyorkensis
(L8)
is
the
key
bacterium
mediating
increased
resistance•Probiotic
strain
L8
thwarts
by
competing
for
carbon
source
fucoseSummaryGut
microbiota
plays
a
crucial
role
resisting
invasion
of
pathogens,
particularly
multidrug-resistant
(MDR)
bacteria,
which
pose
significant
threat
to
public
health.
While
offers
numerous
health
benefits,
its
impact
on
host
remains
largely
unclear.
In
this
study,
we
demonstrate
that
moderate
significantly
reduces
methicillin-resistant
Staphylococcus
aureus
(MRSA),
clinically
important
MDR
pathogen.
Moreover,
identify
an
understudied
intestinal
probiotic
Dubosiella
as
critical
factor
exercise-induced
MRSA.
Mechanistically,
deprivation
fucose,
essential
growth
and
pathogenicity.
This
process
relies
high
binding
affinity
pyruvate
ILE257
site
lactate
dehydrogenase
L8.
Overall,
our
work
highlights
importance
maintaining
demonstrates
protecting
colonization.Graphical
abstract