
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 25, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 25, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 415 - 415
Published: Feb. 9, 2025
Background: Serum mac-2-binding protein glycosylation isomer (M2BPGi) is a new biomarker for liver fibrosis. However, its performance in metabolic dysfunction-associated steatotic disease (MASLD), particularly obese patients, remains to be explored. Methods: This study evaluated the role of M2BPGi predicting fibrosis 205 patients with MASLD using magnetic resonance elastography (MRE) as reference. The was compared vibration-controlled transient (VCTE), FIB-4, APRI, and NFS. PNPLA3, TM6SF2, HSD17B13 polymorphisms were assessed by allelic discrimination assays. Results: area under ROC curves VCTE, NFS differentiating significant 0.95 (95% CI; 0.91-0.98), 0.85 (0.79-0.92), 0.81 (0.74-0.89), 0.79 (0.71-0.87), 0.80 (0.72-0.87) (all p < 0.001), respectively. optimal cut-off values fibrosis, advanced cirrhosis 0.82, 0.95, 1.23 index (COI); yielding satisfactory sensitivity, specificity, diagnostic accuracy. consistent among subgroups according BMI, while AUROCs remarkably decreased BMI ≥ 30 kg/m2. Patients PNPLA3 GG genotype had significantly higher than those CC/CG genotypes. In multivariate analysis, independent factors associated M2BPGi, rs738409. Conclusions: Our data demonstrated that serum accurately across different indicating this could apply non-obese clinical settings.
Language: Английский
Citations
1JGH Open, Journal Year: 2025, Volume and Issue: 9(4)
Published: April 1, 2025
Noninvasive tests (NITs), such as platelet-based indices and ultrasound/MRI elastography, are widely used to assess liver fibrosis in metabolic dysfunction-associated steatotic disease (MASLD). However, platelet counts not routinely included Japanese health check-ups, limiting their utility large-scale screenings. Additionally, while effective, is costly less accessible routine practice. Most existing AI-based models incorporate these markers, restricting applicability. This study aimed develop a simple yet accurate AI model for staging using only demographic biochemical markers. retrospective analyzed biopsy-proven data from 463 MASLD patients. Patients were randomly assigned training (N = 370, 80%) test 93, 20%) cohorts. The incorporated age, sex, BMI, diabetes, hypertension, hyperlipidemia, blood markers (AST, ALT, γ-GTP, HbA1c, glucose, triglycerides, cholesterol). Support Vector Machine demonstrated high diagnostic performance, with an area under the curve (AUC) of 0.886 detecting significant (≥ F2). AUCs advanced F3) cirrhosis (F4) 0.882 0.916, respectively. Compared FIB-4, APRI, FAST score (0.80-0.96), SVM achieved comparable accuracy eliminating need count or elastography. accurately assesses patients without requiring Its simplicity, cost-effectiveness, strong performance make it well-suited screenings clinical use.
Language: Английский
Citations
0World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(5)
Published: May 27, 2025
BACKGROUND The Mac-2 binding protein glycosylated isomer (M2BPGi) is a serum marker for fibrosis that correlates with the stages in various liver diseases. AIM To examine M2BPGi’s threshold staging patients chronic hepatitis B (CHB), and its changes during treatment. METHODS This was prospective, longitudinal study. A total of 348 eligible were recruited from Hepatology Department, Medic Medical Center between March 2020 December 2023. Liver enzyme tests, platelet counts, M2BPGi levels, FibroScan conducted at baseline 3-month intervals until six months post-treatment. Correlation plots M2BPGi, FibroScan, other parameters generated. Receiver operating characteristic curves constructed to evaluate their performance. RESULTS levels correlated well results increased as stage advanced. median different showed statistically significant differences. cut-off values diagnosing (F ≥ 2), advanced (F3), cirrhosis (F4) determined be 1.08, 1.4, 1.52, respectively. In context regression CHB first 6-month treatment, appeared decrease before this pattern occurred results. CONCLUSION strongly FibroScan. can used assess fibrosis, serve tool monitoring undergoing
Language: Английский
Citations
0Hepatology Research, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 10, 2024
Abstract Aim Data on the upregulation of Mac‐2 binding protein (M2BP) expression associated with fat accumulation in liver are limited. Therefore, we aimed to assess relationship between hepatic M2BP and changes microenvironment due patients metabolic dysfunction steatotic disease (MASLD). Methods Liver specimens obtained from 46 MASLD were subjected immunohistochemical staining visualize liver. The intensity hepatocytes sinusoidal cells was classified as high or low grade. First, correlation microenvironmental caused by examined. Then, influence serum glycosylation isomer levels evaluated. Results grade higher than ( p = 0.015). their had more severe lobular inflammation those 0.037). Additionally, presented fibrosis 0.018). correlated positively 0.023), whereas no observed 0.393). Conclusions Fat leads that fibrosis.
Language: Английский
Citations
1Hepatology Research, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 19, 2024
Abstract Aim Type 2 diabetes mellitus (T2DM) is a well‐known risk factor for hepatocellular carcinoma (HCC). However, HCC often diagnosed at an advanced stage in patients with because of the lack best criteria surveillance candidates. The aim this study was to identify factors development nonviral chronic liver disease. Method Three hundred thirty T2DM disease who underwent by imaging techniques between 2009 and 2020 were enrolled multicenter cross‐sectional retrospective study. clinical laboratory parameters without compared. Results Age ≥65 years, alcohol intake, hepatic steatosis, triglyceride level <111 mg/dL, Mac2 binding protein glycosylation isomer (M2BPGi) ≥0.9 cut‐off index (COI), α‐fetoprotein concentration ≥5 ng/mL, des‐γ‐carboxy prothrombin ≥26 mAU/mL independently associated development. When stratified age, only intake (odds ratio [OR] 114.19, p < 0.001) aged <65 medication (OR 5.72, = 0.001), steatosis 4.47, 0.002), lactate dehydrogenase ≥198 IU/L 2.751, 0.031), M2BPGi ≥1.18 COI 9.05, FIB‐4 ≥2.59 3.22, 0.017) years. Conclusions In addition age fibrosis, younger DM older should be considered imaging.
Language: Английский
Citations
1Clinical Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Language: Английский
Citations
1World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(47), P. 5070 - 5075
Published: Nov. 25, 2024
In this article, we comment on the article by Qu and Li, focusing specifically non-invasive diagnostic approaches for metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is most common chronic in children. Nearly half of pediatric cases progress to steatohepatitis at diagnosis, often with comorbidities like renal disease, hypertension, type 2 diabetes, mental health disorders. Early diagnosis continuous intervention are crucial managing "silent organ" disease. Screening recommended children aged nine older obesity. Liver biopsy remains gold standard; however, due its invasiveness, methods - biomarkers, anthropometric algorithms, serum tests, imaging increasingly vital. This editorial provides an overview current or fibrosis.
Language: Английский
Citations
0Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5640 - 5640
Published: Nov. 28, 2024
Regular monitoring of patients with a history hepatitis C virus (HCV) infection is critical for the detection and management hepatocellular carcinoma (HCC). Mac-2 binding protein glycosylation isomer (M2BPGi) has been used to monitor fibrosis progression predict HCC. However, HCC prediction based on M2BPGi not optimized. Here, we identified risk-related glycan signatures M2BP using newly developed automated bead array multiplexed lectins. Among 955 HCV who achieved sustained virological response following direct-acting antiviral treatment, compared from sera 42 diagnosed during follow-up 43 without (control) by lectin microarray. At observation point, found significant differences in 17 Using an 12 lectins, principal component analysis (PCA) biplot differentiated control, along PC1 axis, explaining 75.2% variance. Based PC1, generated scoring formula HCC-related signature (M2BPgs-HCC), showing good diagnostic performance (
Language: Английский
Citations
0Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Citations
0Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Language: Английский
Citations
0