Sonodynamic therapy with a single neoadjuvant, diffuse delivery of low-intensity ultrasound with 5-ALA in treatment naïve glioblastoma results in tumor-specific cytotoxic edema and increased apoptosis

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Purpose Sonodynamic therapy, which combines a tumor cell-selective sonosensitizer with ultrasound, is gaining attention as promising new treatment approach for glioblastoma. The objective of this case study to report on the first applications 5-aminolevulinic acid (5-ALA) in combination low-intensity, non-targeted ultrasound neo-adjuvant therapy naïve Methods Three patients newly diagnosed glioblastoma were treated once before cytoreductive surgery 5-ALA hemispheric, assuming cell death be triggered by non-ablative activation 5-ALA-induced, selective porphyrins. Results No adverse effects noted. Post-procedural MRI indicated decrease apparent diffusion coefficient values tumors, suggesting cytotoxic effects. Relative cerebral blood volumes and leakage increased two available perfusion imaging. Tissue obtained during suggested cleaved-caspase III expression, marker apoptosis. Conclusion We saw an immediate marked imaging response indicating edema indications histopathology from just single treatment. Correlation clinical outcomes extension overall survival remains seen. A Phase 1 safety has been submitted regulatory approval.

Language: Английский

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Emerging nanoplatforms towards microenvironment-responsive glioma therapy

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(2)

Published: Jan. 15, 2025

Language: Английский

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Photodynamic and Sonodynamic Therapy Synergy: Mechanistic Insights and Cellular Responses Against Glioblastoma Multiforme

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Nov. 18, 2024

Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial challenges to effective treatment due its complex and infiltrative nature, making it difficult manage. Photodynamic therapy (PDT) sonodynamic (SDT), have emerged as promising individual options against GBM their least-invasive approach. However, both PDT SDT drawbacks that require careful consideration. A combination using light sound waves has gained attention, offering new avenues overcome from therapies. Sono-photodynamic (SPDT) been used various tumors. Researchers are considering SPDT a favorable alternative conventional therapies for GBM. offers complementary mechanisms action, including production ROS, disruption cellular structures, induction apoptosis, leading enhanced tumor cell death. This review gives an insight about PDT/SDT limitations in need therapy. We try unveil process explore mechanism behind improved SPDT-meditated death cells by focusing on ROS-mediated response occurring result discussing current modifications existing sensitizers optimal use

Language: Английский

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State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature resistance conventional therapies, including surgery, chemotherapy, radiotherapy. Despite advances in standard treatments, patient survival remains limited, requiring exploration of innovative strategies. Photodynamic therapy (PDT) has emerged as promising approach, leveraging light-sensitive photosensitizers (PSs), molecular oxygen, specific light wavelengths generate reactive oxygen species (ROS) that selectively induce tumor cell death. Originally developed for skin cancer, PDT evolved target more complex malignancies, GBM. The refinement second- third-generation PS, coupled with advancements nanotechnology, significantly improved PDT's selectivity, bioavailability, efficacy. Moreover, combination targeted therapy, immunotherapy, among other modalities, shown potential enhancing outcomes. This review provides comprehensive analysis preclinical clinical applications GBM, detailing mechanisms action, evolution novel combinatory strategies optimize treatment However, several challenges remain, overcoming GBM-associated hypoxia, PS delivery across blood-brain barrier, mitigating mechanisms. integration genetic insight, alongside cutting-edge nanotechnology-based systems, may revolutionize GBM treatment, offering new prospects quality life.

Language: Английский

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Photoproducts of Porphyrins with a Focus on Protoporphyrin IX

Photochem, Journal Year: 2025, Volume and Issue: 5(2), P. 10 - 10

Published: April 14, 2025

Porphyrins play important roles in biological systems including oxygen transport and catalysis. Due to their tetrapyrrole core structure, they exhibit exceptional photophysical electrochemical properties find many applications both technical life science fields, photodynamic therapy neurosurgery. The irradiation of porphyrins may cause modifications molecular structure or degradation. Such photobleaching processes potentially affect the success sensitivity photosensitizer applications. While there have been studies using fluorescence spectroscopy investigate this phenomenon, reports about analytically validated structures photoproducts are scarce. It is, however, necessary know individual contributions different molecules signal order evaluate it correctly. This review provides a summary current state knowledge respect, discussing especially hydroxyaldehyde formyl photo-oxidation products protoporphyrin IX.

Language: Английский

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A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review

Current Oncology, Journal Year: 2025, Volume and Issue: 32(1), P. 41 - 41

Published: Jan. 14, 2025

Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of and vary in aggressiveness grade I to IV. Despite advancements neuroimaging surgical techniques, their management remains complex due location near critical cognitive areas. Techniques like awake craniotomy have improved outcomes, but tumor heterogeneity proximity vital structures pose challenges. Radiotherapy chemotherapy offer benefits post-surgery, though issues resistance side effects persist. This article discusses a case report literature review deepen understanding temporo-insular focusing on advanced diagnostic treatment approaches. Materials Methods: A systematic was conducted using PubMed, Embase, Google Scholar, covering studies 2019 July 2024. Keywords included ‘brain tumor’, ‘neurosurgery’, ‘treatment’. Articles glioma diagnosis, management, outcomes were selected, excluding non-English studies, irrelevant reports, non-glioma research, inaccessible texts. Results: From 156 11 met inclusion criteria, highlighting diagnostics, strategies, adjunct therapies for gliomas (TIGs). Gross total resection (GTR) achieved 39% cases. Awake enhanced functional while temozolomide radiotherapy survival. Challenges ischemic complications resistance. Two patient cases underscored the complexity TIG importance individualized approaches, achieving satisfactory with minimal deficits. Conclusions: (TIGs) necessitate multidisciplinary strategy that integrates imaging, meticulous methods, cutting-edge adjuvant therapies. progress techniques use improving significant challenges persist maintaining integrity addressing Ongoing research into targeted therapies, immunotherapies, innovative technologies advancing care long-term prognosis.

Language: Английский

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Nanotechnology-based platforms for effective and versatile sonodynamic therapy in cancer treatment

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(27), P. 2251 - 2255

Published: Oct. 15, 2024

Language: Английский

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Preliminary investigation of nitric oxide release from upconverted nanoparticles excited at 808 nm near-infrared for brain tumors

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33576 - e33576

Published: June 26, 2024

Language: Английский

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Noninvasive, Drug Augmented, Ultra Low Intensity Transcranial Light Photodynamic Treatment of Glioblastoma: LIT-PDT

Published: July 25, 2024

This paper presents the rationale for using ultra low intensity transcranial light photodynamic treatment (LIT-PDT) treating glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide and ionizing irradiation. Mortality in 2024 remains at over 80% within several years from diagnosis. 5-aminolevulinic acid (5-ALA) a heme precursor that selectively taken up preferentially by malignant cells, including Photon energy can be transduced to molecular oxygen 5-ALA metabolite, PpIX, transforming singlet state, reactive species (ROS) destroys or damages vital glioblastoma cell structures. In PDT, ~ 100 200 J / cm2, 630 nm delivered intraoperatively after resection preoperative oral 5-ALA. generates ROS cytotoxicity residual cells cavity wall. poorly penetrates skin, skull, brain tissue. That restricts PDT single intraoperative session high flux light. LIT-PDT addresses some current shortcomings of treatment. Part 1 analyzes published data indicating continuous flux, 17 μW 24 hours total delivery 1.5 effective opens way repetitive, extracranial deliver enough long duration any deep structure less than 12 W distributed entire scalp area. 2, analysis PpIX physiology, it became apparent four non oncology drugs - ciprofloxacin, deferiprone, telmisartan ziprasidone, will increase capture GB thereby increasing cytotoxicity. A phased pilot study being planned.

Language: Английский

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Nano-fluorescence imaging: advancing lymphatic disease diagnosis and monitoring

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 11, 2024

The lymphatic system plays a crucial role in maintaining physiological homeostasis and regulating immune responses. Traditional imaging modalities such as magnetic resonance imaging, computerized tomography, positron emission tomography have been widely used to diagnose disorders the system, including lymphedema, lymphangioma, metastasis, Castleman disease. Nano-fluorescence technology has distinct advantages-including naked-eye visibility, operational simplicity, portability of laser, real-time visibility-and serves an innovative alternative traditional techniques. This review explores recent advancements nano-fluorescence aimed at enhancing resolution structure, function, immunity. After delineating fundamental characteristics systems, it elaborates on development various systems (including nanoparticles incorporating fluorescent dyes those with intrinsic fluorescence) while addressing key challenges photobleaching, limited tissue penetration, biocompatibility, signal interference from biomolecules. Furthermore, this highlights clinical applications its potential integration into standard diagnostic protocols. Ongoing nanoparticle underscore revolutionize diagnosis treatment

Language: Английский

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