Menoufia Medical Journal,
Journal Year:
2023,
Volume and Issue:
36(3)
Published: Dec. 26, 2023
Objectives:
To
study
the
relation
between
angiotensin
I
converting
enzyme
(ACE)
and
receptor
for
advanced
glycation
end
products
(RAGE)
genes
in
children
with
type
1
diabetes
presented
by
renal
complications.
Background:
In
patients
diabetes,
an
association
has
been
found
insertion/deletion
(I/D)
polymorphism
gene
ACE
presence
of
diabetic
nephropathy.
Methods:
A
cross
section
was
conducted
on
50
Egyptian
complications
from
our
endocrinology,
genetic
unit
outpatient
clinic
pediatric
department,
Menoufia
University,
during
a
period
time
April
2021
to
October
2022.
Results:
there
significant
difference
cases
control
groups
regarding
its
alleles,
(P0.05).
Conclusion:
Our
concluded
that
ID
can
markedly
increase
incidence
diabetes-related
end-stage
disease.
data
suggests
interact
modulating
progression
nephropathy
individual
risk
being
fast
progressor
patients.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0310218 - e0310218
Published: Jan. 24, 2025
Diabetes,
a
chronic
condition
affecting
millions
worldwide,
necessitates
early
intervention
to
prevent
severe
complications.
While
accurately
predicting
diabetes
onset
or
progression
remains
challenging
due
complex
and
imbalanced
datasets,
recent
advancements
in
machine
learning
offer
potential
solutions.
Traditional
prediction
models,
often
limited
by
default
parameters,
have
been
superseded
more
sophisticated
approaches.
Leveraging
Bayesian
optimization
fine-tune
XGBoost,
researchers
can
harness
the
power
of
data
analysis
improve
predictive
accuracy.
By
identifying
key
factors
influencing
risk,
personalized
prevention
strategies
be
developed,
ultimately
enhancing
patient
outcomes.
Successful
implementation
requires
meticulous
management,
stringent
ethical
considerations,
seamless
integration
into
healthcare
systems.
This
study
focused
on
optimizing
hyperparameters
an
XGBoost
ensemble
model
using
optimization.
Compared
grid
search
(accuracy:
97.24%,
F1-score:
95.72%,
MCC:
81.02%),
with
achieved
slightly
improved
performance
97.26%,
MCC:81.18%).
Although
improvements
observed
this
are
modest,
optimized
represents
promising
step
towards
revolutionizing
treatment.
approach
holds
significant
outcomes
for
individuals
at
risk
developing
diabetes.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(18), P. 6053 - 6053
Published: Sept. 19, 2023
Type
2
diabetes
mellitus
(T2DM)
still
holds
the
title
as
one
of
most
debilitating
chronic
diseases
with
rising
prevalence
and
incidence,
including
its
complications
such
retinal,
renal,
peripheral
nerve
disease.
In
order
to
develop
novel
molecules
for
diagnosis
treatment,
a
deep
understanding
complex
molecular
pathways
is
imperative.
Currently,
existing
agents
T2DM
treatment
target
only
blood
glucose
levels.
Over
past
decades,
specific
building
blocks
proteins-branched-chain
amino
acids
(BCAAs)
leucine,
isoleucine,
valine-have
gained
attention
because
they
are
linked
insulin
resistance,
pre-diabetes,
development.
this
review,
we
discuss
hypothetical
link
between
BCAA
metabolism,
T2DM,
microvascular
diabetic
retinopathy
nephropathy.
Further
research
on
these
their
derivates
may
eventually
pave
way
biomarkers
or
therapeutic
concepts
accompanied
complications.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 26, 2023
It
is
accepted
that
plasma
branched-chain
amino
acids
(BCAAs)
and
aromatic
(AAAs)
are
closely
related
to
metabolic
risk.
Arterial
hypertension,
syndrome,
endothelial
dysfunction,
inflammation,
dysfunction-associated
fatty
liver
disease
(MAFLD)
frequently
seen
in
obese
patients.
Many
attempts
have
been
made
find
biochemical
indicators
for
the
early
detection
of
complications
children.
not
known
if
different
acid
profiles
BCAA
AA
concentrations
overweight
children
correlate
with
chemerin,
proinflammatory,
simple
markers.
Thus,
study
aimed
out
markers
cardiovascular
MAFLD
The
included
20
(M/F
12/8;
mean
age
7.7
±
2.3
years;
BMI
26.8
5.0
kg/m2)
12
non-obese
(control
group)
4/8;
6.5
2.2
14.8
1.5
kg/m2).
following
were
measured:
aspartic
acid,
glutamic
serine,
asparagine,
glycine,
glutamine,
taurine,
histidine,
citrulline,
threonine,
alanine,
arginine,
proline,
tyrosine,
methionine,
valine,
isoleucine,
leucine,
phenylalanine,
tryptophan,
ornithine,
lysine.
Chemerin,
high-sensitivity
C-reactive
protein
(hs-CRP),
interleukin-6
(IL-6),
basic
biochemistry
parameters
measured.
levels
alanine
significantly
higher
than
control
group
(p<0.03-p<0.0004).
Conversely,
values
citrulline
lower
(p<0.03-p<0.0007).
Isoleucine,
valine
phenylalanine
showed
a
positive
correlation
uric
ALT,
hs-CRP,
chemerin
(r=0.80-0.36;
p<0.05-p<0.00001),
but
IL-6.
glucose,
IL-6,
ALT
(p<0.03-p<0.00002).
In
contrast,
lipid
profile
did
differ
between
groups.
An
abnormal
pre-pubertal
children,
accompanied
by
elevated
UA
observed
studied
cohort,
may
suggest
disturbances
can
potentially
lead
or
MAFLD,
increased
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(17), P. e36286 - e36286
Published: Aug. 23, 2024
This
study
investigates
the
significance
of
quantifying
amino
acids
in
minute
sweat
volumes
using
high-performance
liquid
chromatography
with
fluorescence
detection.
Sweat,
a
valuable
biofluid
for
non-invasive
health
monitoring,
provides
real-time
insights
into
physiological
changes.
Amino
acids,
which
are
critical
various
processes,
key
to
protein
synthesis
and
cellular
regulation.
Therefore,
analyzing
sweat's
acid
profiles
can
offer
metabolic
states,
exercise-induced
stress,
potential
biomarkers
conditions.
For
sensitive
analysis,
were
derivatized
4-fluoro-7-nitro-2,1,3-benzoxadiazole
(NBD-F),
followed
by
chromatographic
separation
on
an
octadecylsilyl
column
The
developed
method
was
validated
applied
human
samples,
enabling
quantification
14
acids.
most
abundant
samples
serine,
glycine,
alanine,
aligns
prior
studies.
offers
efficient
way
screen
diseases
detecting
sweat,
even
minimal
volumes.
approach
could
also
be
used
analyze
other
biomolecules
expanding
its
applications.
Future Microbiology,
Journal Year:
2024,
Volume and Issue:
20(3), P. 237 - 246
Published: Dec. 22, 2024
A
notable
scarcity
of
research
has
focused
on
examining
alterations
in
gut
microbiota
and
its
metabolites
within
tacrolimus
(TAC)-induced
diabetes
models.
Tacrolimus-induced
changes
glucose
lipid
metabolism
indices
were
analyzed
through
different
routes
administration.
The
potential
role
TAC-induced
was
investigated
using
16S
rRNA
sequencing
non-targeted
metabolomics.
After
intraperitoneal(ip)
oral(po)
administration
TAC,
the
α-diversity
index
significantly
increased.
three
groups
mice
separated,
there
significant
composition
functional
genes.
Fecal
changed
after
TAC
by
routes,
53
(38
down-regulated
15
up-regulated)
identified
(CON
vs.
TACip).
Similarly,
29
(8
21
TACpo).
KEGG
pathway
analysis
4
13
altered
metabolic
pathways,
respectively.
Correlation
suggested
that
involved
pathogenesis
diabetes.
This
study
fecal
diabetic
evaluated
correlation
between
these
changes.
These
findings
provide
valuable
insights
into
biomarkers
development
The Ukrainian Biochemical Journal,
Journal Year:
2023,
Volume and Issue:
95(6), P. 30 - 39
Published: Dec. 14, 2023
Studies
targeting
small
molecule
metabolites
(amino
acids,
sugars,
nucleotides,
lipids)
in
connections
with
gut
microbiota
that
impact
the
host
metabolome
give
a
possibility
to
define
special
metabolic
signature
of
different
diseases.
Plasma
amino
acids
(AA)
profile
is
known
be
new
promising
biomarker
for
screening
coronary
artery
disease
(CAD)
pathogenesis
connected
dysbiosis.
The
aim
our
study
was
estimate
spectrum
plasma
CAD
patients
atrial
fibrillation
(AF)
and
check
their
metabolites.
300
were
divided
into
three
groups:
–
149
but
without
arrhythmias,
CAD+AF
123
AF
paroxysm
control
group–
28
arrhythmias.
AA
level
detected
by
ion
exchange
liquid
column
chromatography.
Significant
changes
content
Glutamate,
Glutamine,
Glycine,
Alanine,
Valine
Tyrosine
combinations
Isoleucine+Leucine/Valine,
Glycine+Serine,
Glycine/Methionine,
Phenylalanine/Tyrosine,
Glutamine/Glutamate
detected.
A
strong
reliable
connection
between
trimethylamine,
trimethylamine-N-oxide
total
amount
fecal
short
chain
fatty
determined.
highly
validated
Isoleucine
Glycine
(area
under
ROC-curve
0.8122)
Phenylalanine
0.8061)
can
used
as
early
markers
proposed.
Keywords:
fibrillation,
cardiometabolic
risk
factors,
disease,
metabolites,
Medicni perspektivi,
Journal Year:
2023,
Volume and Issue:
28(4), P. 13 - 22
Published: Dec. 25, 2023
The
aim
of
our
work
was
to
estimate
the
plasma
amino
acid
(AA)
spectrum
peculiarities
in
coronary
artery
disease
(CAD)
patients
with
atrial
fibrillation
(AF)
and
check
their
connections
cardiometabolic
risk
factors
gu,
microbiota
metabolites.
300
were
divided
into
three
groups:
first
–
149
CAD
but
without
arrhythmias,
second
123
AF
paroxysm
control
group
28
arrhythmias.
Plasma
AA
level
detected
by
ion
exchange
liquid
column
chromatography
method.
changes
investigated:
some
(glutamate,
glutamine,
glycine,
alanine,
valine,
tyrosine)
combinations
(Isoleucine+Leucine/Valine,
Glycine+Serine,
Glycine/Methionine,
Phenylalanine/Tyrosine,
Glutamine/Glutamate)
had
significant
correlations
(glycine,
arginine,
glutamate,
isoleucine,
methionine
(p<0.05)).
revealed,
lattert
could
be
used
as
an
early
marker
results
ROC
analysis:
2.44
*
Isoleucine
Glycine;
area
under
ROC-curve
0.8122
3.16
Phenylalanine
Glycine,
0.8061.
evaluation
a
new
promising
metabolic
for
patients.
Altered
levels
point
depth
pathogenetic
during
formation:
disorders
metabolism
branched
chain
(isoleucine,
leucine,
valine),
aromatic
(phenylalanine,
tyrosine),
glutamine/glutamate,
glycine/serine
glycine/methionine
metabolism.
A
strong
reliable
connection
between
gut
metabolites
(trimethylamine,
trimethylamine-N-oxide,
total
amount
fecal
short
fatty
acids)
detected.
