Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Sepsis, a medical emergency with high mortality rates, demands comprehensive care spanning from early identification to patient rehabilitation. The sepsis survival chain encompasses recognition, severity assessment, activation of services, initial antimicrobial therapy, hemodynamic stabilization, and integrated These interconnected steps are critical reducing morbidity mortality. Despite advancements in international guidelines, adherence remains limited, contributing significant disease burden. Beyond its acute phase, post-sepsis syndrome (PSS) is characterized by long-term immune dysregulation, chronic inflammation, metabolic dysfunction, predisposing survivors recurrent infections, cardiovascular disease, neurocognitive decline. Mitochondrial dysfunction epigenetic modifications play central role prolonged immunosuppression, impairing adaptive innate responses. Sepsis-induced organ impacts multiple systems, including the brain, heart, kidneys. In it associated neuroinflammation, blood-brain barrier accumulation neurotoxic proteins, leading cognitive impairment. Myocardial involves inflammatory mediators such as TNF-α IL-6, while sepsis-associated kidney injury (SA-AKI) arises hypoperfusion heightening risk progression disease. Additionally, alterations neutrophil continuous platelet activation, suppressed antitumoral responses contribute increased infection complications. Timely targeted interventions, cytokine modulation, restoration, support, structured rehabilitation strategies, pivotal for improving outcomes. However, financial infrastructural limitations low-resource settings pose barriers effective management. Precision medicine, AI-driven warning optimized referral networks can enhance detection personalized treatments. Promoting public professional awareness sepsis, strengthening multidisciplinary care, integrating follow-up programs imperative priorities quality life survivors.

Language: Английский