Arhiv za farmaciju,
Journal Year:
2023,
Volume and Issue:
73(6), P. 484 - 514
Published: Jan. 1, 2023
The
human
gut
microbiota
is
a
diverse
ecosystem
that
harbours
variety
of
microorganisms,
including
proteobacteria,
bacteria,
viruses,
fungi,
protists,
and
archaea.
These
microorganisms
are
collectively
involved
in
several
vital
functions,
nutrient
metabolism,
vitamin
synthesis,
immune
system
regulation,
neurotransmitter
production,
drug
communication
with
the
central
nervous
system.
Dysbiosis
within
has
been
shown
to
be
critical
factor
development
chronic
disease.
Investigating
effects
composition
on
overall
health
holds
promise
for
treatment
inflammatory
diseases
new
therapeutic
interventions.
One
notable
aspect
functionality
its
involvement
production
essential
B
vitamins.
vitamins
exert
significant
influence
responses
microbiota.
Competition
may
occur
between
host
vitamins,
which
some
bacteria
obtain
from
food
or
synthesis
by
other
bacteria.
Thus,
availability
diet
potential
thus
homeostasis.
profile
varies
individually,
proving
an
important
modulator
both
functional
properties.
However,
further
extensive
research
efforts
needed
understand
complex
interplay
microbiota,
response
mechanisms.
Such
investigations
have
develop
innovative
strategies
spectrum
diseases,
opening
avenues
improved
patient
outcomes.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2302 - 2302
Published: July 17, 2024
Inflammatory
bowel
disease
(IBD),
a
complex
chronic
inflammatory
disorder
that
includes
Crohn’s
(CD)
and
Ulcerative
Colitis
(UC),
has
become
globally
increasing
health
concern.
Nutrition,
as
an
important
factor
influencing
the
occurrence
development
of
IBD,
attracted
more
attention.
As
most
nutrient,
protein
can
not
only
provide
energy
nutrition
required
by
patients,
but
also
help
repair
damaged
intestinal
tissue,
enhance
immunity,
thus
alleviate
inflammation.
Numerous
studies
have
shown
nutritional
support
plays
significant
role
in
treatment
remission
IBD.
This
article
presents
comprehensive
review
pathogenesis
IBD
analyzes
summarizes
potential
mechanisms
Additionally,
it
provides
overview
clinical
effects
its
impact
on
complications.
Research
findings
reveal
demonstrates
benefits
improving
symptoms,
reducing
risk
complications,
quality
life
patients.
Therefore,
is
expected
to
new
approach
for
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 450 - 450
Published: Jan. 26, 2025
Chronic
diseases
have
emerged
as
a
significant
challenge
in
global
public
health
due
to
their
complex
etiologies,
prolonged
disease
courses,
and
high
treatment
costs.
With
the
aging
population
changes
lifestyle,
number
of
patients
with
chronic
has
increased
dramatically,
which
brought
heavy
burden
families
society.
are
often
accompanied
by
digestive
absorptive
disorders
well
metabolic
disorders,
resulting
insufficient
nutrient
intake,
further
worsening
condition
weakening
physique.
Therefore,
importance
nutritional
intervention
management
become
increasingly
prominent.
As
an
important
means
intervention,
enteral
nutrition
plays
key
role
improving
status
patients,
promoting
rehabilitation,
shortening
hospital
stay
so
on,
thereby
providing
new
solution
for
management.
This
article
reviews
current
application
status,
mechanism
action
comprehensive
benefit
clinical
diseases.
Through
systematic
review
analysis
existing
research
findings,
specific
effects
mechanisms
clarified.
aims
promote
popularization
nutrition,
order
effectively
improve
patients’
outcomes
quality
life,
provide
scientific
evidence
optimization
strategies
diseases,
offer
theoretical
support
development
products,
drive
continuous
improvement
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
SUMMARY
Laboratory-raised
mice
live
approximately
seven
times
longer
and
healthier
lives
compared
to
their
wild
counterparts,
due
a
standardized
healthy
diet
limited
exposure
environmental
stressors
1
.
Aging
is
associated
with
increased
inflammation
microbial
dysbiosis
2–4
Collectively,
these
influence
microbiota
evolution
may
contribute
the
enrichment
in
pathobiont
frequency
observed
old
age
4
Alternatively,
this
increase
could
stem
from
decline
colonization
resistance
5,6
,
creating
favorable
conditions
for
invasion.
Here,
we
sought
test
whether
aging
healthy,
controlled
conditions,
prevent
selection
of
age-associated
pathobionts.
We
have
followed
adaptive
commensal
strain
Escherichia
coli
guts
advanced
found
that
it
acquired
several
mutations
common
bacteria
colonizing
young
mice,
which
were
absent
animals.
This,
together
Akkermansia
muciniphila
age,
suggest
7,8
However,
exclusively
older
mainly
pathoadaptive,
tuning
metabolism
oxygen
iron
availability,
hypermotility,
biofilm
formation.
In
summary,
while
evolutionary
signature
very
shows
youth-like
features
be
longevity,
pathoadaptive
traits
magnified
age.
While
suggesting
breach
not
needed
justify
abundance
pathobionts,
our
findings
raise
question
specialized
bacteria,
as
opposing
generalists
such
E.
will
display
same
ability
evolve
traits.
Highlights
Gut
commensals
face
increasingly
personalized
selective
pressures
gut
Even
selects
‘s
pattern
better
reflects
metabolome
than
composition
Brief
Pathobionts
are
often
enriched
elderly.
Melo-Miranda
et
al.
showed
irrespectively
limiting
opportunity
invasion,
strength
pathoadaptation
increases
aging.
Yet,
environment
extreme
ages
seems
converge,
highlighting
discontinuity
process.
Foods,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1815 - 1815
Published: June 8, 2024
In
the
current
study,
prebiotic
potential
of
an
innovative
functional
pasta
enriched
with
12%
(w/w)
inulin
was
investigated.
To
this
aim,
subjected
to
in
vitro
gastrointestinal
digestion
followed
by
simulated
gut
fermentation
compared
control
(CTRL)
not
containing
inulin.
The
incorporation
positively
(p
<
0.05)
affected
some
organoleptic
traits
and
cooking
quality
final
product,
giving
overall
score
significantly
higher
than
CTRL.
resultant
essential
amino
acid
content
similar
both
samples
while
total
protein
lower
inulin-enriched
for
polymer
substitution
durum
wheat
flour.
chicory
preliminarily
tested
experiments
using
seven
probiotic
strains
among
them
Lacticaseibacillus
paracasei
IMPC2.1
selected
studies.
positive
activity
registered
strain
suggested
suitability
respect
acting
as
a
source
favoring
growth
short
chain
fatty
(SCFA)
production.
present
study
contributes
broadening
knowledge
on
efficacy
when
incorporated
into
complex
food
matrix.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4124 - 4124
Published: April 26, 2025
Antibiotic-resistant
bacteria
are
major
contributors
to
food
spoilage,
animal
diseases,
and
the
emergence
of
multidrug-resistant
(MDR)
in
healthcare,
highlighting
urgent
need
for
effective
treatments.
Bacteriocins
produced
by
lactic
acid
(LAB)
have
gained
attention
their
non-toxic
nature
strong
antimicrobial
properties.
LAB-derived
bacteriocins
been
successfully
applied
preservation
classified
U.S.
Food
Drug
Administration
(FDA)
as
‘food-grade’
or
‘generally
recognized
safe’
(GRAS).
This
review
summarizes
recent
progress
production,
purification,
emerging
applications
LAB
bacteriocins.
It
emphasizes
versatility
preservation,
agriculture,
medicine,
providing
insights
into
role
development
functional
innovation.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19374 - e19374
Published: May 5, 2025
Background
Increasing
evidence
has
shown
a
close
relation
between
the
pathogenesis
of
type
2
diabetes
mellitus
(T2DM),
which
is
global
health
problem
with
multifactorial
etiopathogenesis,
and
gut
microbiota.
Methods
During
in-vitro
fermentation
Scrophularia
ningpoensis
(known
as
Xuanshen)
polysaccharide
(SNP)
by
T2DM
microbiota,
effects
SNP
on
gas
content,
production
short-chain
fatty
acids
(SCFAs),
metabolite
profile
microbiota
composition
were
studied.
Results
Analysis
chemical
compositions
indicates
that
total
sugar
content
was
found
to
be
high
87.35
±
0.13%
(w/w).
treatment
significantly
improved
volume
in
fecal
matter.
Moreover,
intestinal
flora
degraded
produce
SCFAs,
thus
regulating
SCFA
composition.
Metabolomic
analysis
implied
shows
potential
regulate
five
metabolites
(L-valine,
L-leucine,
L-isoleucine,
L-alanine,
xylitol)
Furthermore,
dysbiosis
induced
reversed
SNP.
The
includes
decreasing
Firmicutes
/
Bacteroidota
ratio
at
phylum
level
promoting
proliferation
bacterial
abundance
Dorea
,
Parabacteroides
Faecalibacterium
Lachnospira
decreased
Escherichia—Shigella
.
Based
these
findings,
action
mechanism
against
clarified
reshaping
metabolites,
novel
target
provided
for
interventions
T2DM.
