Clinical Efficacy of NIBS in Enhancing Neuroplasticity for Stroke Recovery

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110399 - 110399

Published: Feb. 1, 2025

Language: Английский

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Transcranial direct current stimulation for upper and lower limb motor dysfunction after stroke: a systematic review and meta-analysis of randomized controlled trials

Brain Network and Modulation, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 12

Published: Jan. 1, 2025

Transcranial direct current stimulation (tDCS) has emerged as a promising noninvasive intervention for motor recovery after stroke, yet its therapeutic efficacy remains unclear. This study was designed to systematically evaluate the effectiveness of tDCS upper and lower extremity function in stroke patients. A comprehensive search conducted randomized controlled trials published before February 6, 2025, across five databases: PubMed, Embase, Web Science, Cochrane Library, Scopus. The Fugl-Meyer Assessment Scales Upper Lower Extremities served primary evaluation metrics, complemented by secondary measures, including Action Research Arm Test, Timed Up Go Barthel Index. Two independent investigators screened literature, Risk Bias Tool employed assess quality extract relevant data. total 24 were included analysis. Meta-analysis outcomes revealed that had positive effect on improving limb (mean difference ( MD ) = 1.628, 95% confidence interval CI ): 1.145-2.111, P < 0.001) but not improvement 1.133, : –0.031–2.298, 0.056). Subgroup analyses optimal parameters: anodal M1 region 1.707, 1.159–2.256), intensity ≥ 0.05 mA/cm 2 1.652, 0.862–2.442), treatment duration exceeding weeks 1.848, 0.703–2.994). Notably, benefits particularly evident during acute subacute rehabilitation phases. Current evidence suggests demonstrates clinically meaningful enhancement patients, whereas functional inconclusive.

Language: Английский

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Comparison of the effects of transcranial direct current stimulation combined with different rehabilitation interventions on motor function in people suffering from stroke-related symptoms: a systematic review and network meta-analysis

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: June 4, 2025

Background This study employs network meta-analysis to assess the efficacy of transcranial direct current stimulation (tDCS) combined with different rehabilitation approaches in enhancing motor function people suffering from stroke-related symptoms (PSSS). The objective is determine most effective tDCS-based approach and offer valuable evidence guide clinical decision-making. Methods included randomized controlled trials (RCTs) published before September 23, 2024. We conducted a systematic search across eight databases: PubMed, Embase, Cochrane Library, Web Science, China National Knowledge Infrastructure (CNKI), Biology Medicine (SinoMed), Wanfang, VIP. Network (NMA) was utilizing R Studio Stata 15.0 for data analysis. Results A total 74 RCTs were this study, encompassing 4,335 PSSS 11 intervention strategies. NMA revealed that brain-computer interface therapy (BCIT) combination tDCS [surface under cumulative ranking curve (SUCRA) = 88.34%] improving Fugl-Meyer Assessment Upper Extremity score PSSS. Mirror (MT) (SUCRA 85.96%) identified as optimal Action Research Arm Test MT + 84.29%) best Lower score. Additionally, acupuncture moxibustion (AM) 77.16%) increasing Berg Balance Scale two-dimensional clustering analysis showed 75.83%/85.96%) strategy treating upper limb dysfunction PSSS, while AM+tDCS 76.94%/77.16%) lower Conclusion BCIT+tDCS ability arm mobility, protocol ability, balance ability. Furthermore, dysfunction, whereas addressing Future studies may focus on investigating therapeutic effects well AM score, order further explore potential these two Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024621998 , Identifier PROSPERO CRD42024621998.

Language: Английский

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Effects of Cerebellar Non-Invasive Stimulation on Neurorehabilitation in Stroke Patients: An Updated Systematic Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1348 - 1348

Published: June 18, 2024

The cerebellum is emerging as a promising target for noninvasive brain stimulation (NIBS). A systematic review was conducted to evaluate the effects of cerebellar NIBS on both motor and other symptoms in stroke rehabilitation, its impact functional ability, potential side (PROSPERO number: CRD42022365697). electronic database search performed by using PubMed Central (PMC), EMBASE, Web Science, with cutoff date November 2023. Data extracted included study details, methodology, outcome measures, results. risk bias eligible studies also assessed. Twenty-two clinical involving 1016 participants were finally included, focus outcomes related post-stroke recovery (gait balance, muscle spasticity, upper limb dexterity) functions (dysphagia aphasia). Positive observed, especially like gait balance. Some efficiency observed dysphagia rehabilitation. However, findings language preliminary inconsistent. slight improvement ability noted, no serious adverse reported. Further are needed explore non-motor deficits understand how engagement can facilitate more precise treatment strategies

Language: Английский

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Comparative efficacy and acceptability of non-invasive neuromodulation technologies and botulinum toxin injections for post-stroke spasticity and motor function: a network meta-analysis of randomised controlled trials

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 80, P. 103034 - 103034

Published: Dec. 27, 2024

Language: Английский

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