The role of inflammatory gene polymorphisms in severe COVID-19: a review DOI Creative Commons
J Yip, Adrian Oo,

Yan Ling Ng

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 20, 2024

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over past three years. One critical aspect of disease is intricate interplay between virus host immune response, particularly role inflammatory gene expression in severe COVID-19. While numerous previous studies have explored genetic polymorphisms COVID-19, specifically focusing on genes their associations with severity remains limited. This review explores relationship outcomes within key genes. By investigating impact variations responses, which include cytokine production downstream signalling pathways, we aim to provide a comprehensive overview how contribute variability presentation. Through an in-depth analysis existing literature, shed light potential therapeutic targets personalized approaches that may enhance our understanding pathogenesis treatment strategies.

Language: Английский

The role of inflammatory gene polymorphisms in severe COVID-19: a review DOI Creative Commons
J Yip, Adrian Oo,

Yan Ling Ng

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 20, 2024

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over past three years. One critical aspect of disease is intricate interplay between virus host immune response, particularly role inflammatory gene expression in severe COVID-19. While numerous previous studies have explored genetic polymorphisms COVID-19, specifically focusing on genes their associations with severity remains limited. This review explores relationship outcomes within key genes. By investigating impact variations responses, which include cytokine production downstream signalling pathways, we aim to provide a comprehensive overview how contribute variability presentation. Through an in-depth analysis existing literature, shed light potential therapeutic targets personalized approaches that may enhance our understanding pathogenesis treatment strategies.

Language: Английский

Citations

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