Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(6), P. 2827 - 2841
Published: Feb. 3, 2023
In
order
to
develop
anthranilic
diamides
with
novel
chemotypes,
a
series
of
acrylamide
linkers
were
designed
and
synthesized.
The
results
preliminary
bioassays
indicated
that
compounds
monofluoroalkene
amide
linker
(Z-isomer)
exhibited
good
larvicidal
activity
against
lepidopteran
pests.
LC50
values
compound
A23
Mythimna
separata
Plutella
xylostella
1.44
3.48
mg·L-1,
respectively,
while
those
chlorantraniliprole
0.08
0.06
respectively.
Compound
also
the
same
level
lethal
potency
resistant
susceptible
strains
Spodoptera
frugiperda
at
50
mg·L-1.
similar
symptoms
as
in
test
larvae.
Comparative
molecular
field
analysis
was
conducted
demonstrate
structure-activity
relationship.
Central
neuron
calcium
imaging
experiments
potential
ryanodine
receptor
(RyR)
activators
activated
channels
both
endoplasmic
reticulum
cell
membrane.
Molecular
docking
suggested
had
better
binding
P.
RyR
than
chlorantraniliprole.
MM|GBSA
dG
bind
value
117.611
kcal·mol-1.
Monofluoroalkene
introduced
into
diamide
insecticides
for
first
time
brought
chemotype
insect
activators.
feasibility
fluoroalkenes
insecticide
fragments
explored.
Insect Biochemistry and Molecular Biology,
Journal Year:
2023,
Volume and Issue:
156, P. 103937 - 103937
Published: April 5, 2023
Aphids
are
a
group
of
hemipteran
insects
that
include
some
the
world's
most
economically
important
agricultural
pests.
The
control
pest
aphids
has
relied
heavily
on
use
chemical
insecticides,
however,
evolution
resistance
poses
serious
threat
to
their
sustainable
control.
Over
1000
cases
have
now
been
documented
for
involving
remarkable
diversity
mechanisms
that,
individually
or
in
combination,
allow
toxic
effect
insecticides
be
avoided
overcome.
In
addition
its
applied
importance
as
growing
human
food
security,
insecticide
also
offers
an
exceptional
opportunity
study
under
strong
selection
and
gain
insight
into
genetic
variation
fuelling
rapid
adaptation.
this
review
we
summarise
biochemical
molecular
underlying
aphid
pests
worldwide
insights
topic
provided
genomic
architecture
adaptive
traits.
Insects,
Journal Year:
2020,
Volume and Issue:
11(8), P. 545 - 545
Published: Aug. 18, 2020
Fall
armyworm
(FAW),
Spodoptera
frugiperda,
a
major
pest
of
corn
and
native
to
the
Americas,
recently
invaded
(sub)tropical
regions
worldwide.
The
intensive
use
insecticides
high
adoption
crops
expressing
Bacillus
thuringiensis
(Bt)
proteins
has
led
many
cases
resistance.
Target-site
mutations
are
among
main
mechanisms
resistance
monitoring
their
frequency
is
great
value
for
insecticide
management.
Pyrosequencing
PCR-based
allelic
discrimination
assays
were
developed
used
genotype
target-site
alleles
in
34
FAW
populations
from
different
continents.
diagnostic
methods
revealed
acetylcholinesterase,
conferring
organophosphates
carbamates.
In
voltage-gated
sodium
channels
targeted
by
pyrethroids,
only
one
population
Indonesia
showed
mutation.
No
detected
ryanodine
receptor,
suggesting
susceptibility
diamides.
Indels
ATP-binding
cassette
transporter
C2
associated
with
Bt-resistance
observed
samples
collected
Puerto
Rico
Brazil.
Additionally,
we
analyzed
all
presence
markers
two
sympatric
host
plant
strains.
molecular
established
show
robust
results
across
broad
geographical
range
can
be
support
decisions
sustainable
control
applied
Journal of Agricultural and Food Chemistry,
Journal Year:
2021,
Volume and Issue:
69(16), P. 4564 - 4577
Published: April 13, 2021
Bacillus
thuringiensis
(Bt)
has
been
recognized
for
its
high
potential
in
the
control
of
various
agricultural
pests.
Developments
micro/nanotechnology
have
opened
new
perspectives
production
more
efficient
formulations
that
can
overcome
some
obstacles
associated
with
use
field,
such
as
formulation
instability
and
loss
activity
a
result
degradation
pesticidal
protein
by
exposure
to
ultraviolet
radiation,
among
other
problems.
This
review
describes
current
studies
recent
discoveries
related
Bt
processes
encapsulation
derivatives,
Cry
proteins.
Different
techniques
are
described,
extrusion,
emulsion,
spray
drying,
cooling,
fluidized
bed,
lyophilization,
coacervation,
electrospraying
obtain
micro-
nanoparticulate
systems.
It
is
noteworthy
products
based
on
microorganisms
present
less
risk
environment
non-target
organisms.
However,
systematic
assessment
these
biopesticides
necessary,
considering
issues,
interactions
organisms,
formation
toxic
secondary
metabolites,
or
interspecific
transfer
genetic
material.
Given
great
formulations,
critical
provided
their
future
use,
technological
challenges
must
be
achieve
large-scale
use.
The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
915, P. 170174 - 170174
Published: Jan. 19, 2024
Bees
carry
out
vital
ecosystem
services
by
pollinating
both
wild
and
economically
important
crop
plants.
However,
while
performing
this
function,
bee
pollinators
may
encounter
potentially
harmful
xenobiotics
in
the
environment
such
as
pesticides
(fungicides,
herbicides
insecticides).
Understanding
key
factors
that
influence
toxicological
outcomes
of
exposure
to
these
chemicals,
isolation
or
combination,
is
essential
safeguard
their
health
they
provide.
In
regard,
recent
work
using
toxicogenomic
phylogenetic
approaches
has
begun
identify,
at
molecular
level,
determinants
pesticide
sensitivity
pollinators.
These
include
detoxification
systems
convert
less
toxic
forms
residues
insecticide
target-sites
underlie
species-specific
selectivity.
Here
we
review
emerging
body
research
summarise
state
knowledge
We
identify
gaps
our
for
future
examine
how
an
understanding
genetic
basis
can
be
leveraged
to,
a)
predict
avoid
negative
bee-pesticide
interactions
facilitate
development
pest-selective
bee-safe
insecticides,
b)
inform
traditional
effect
assessment
risk
address
issues
ecotoxicological
concern.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0318154 - e0318154
Published: Jan. 29, 2025
Insecticide
resistance
is
a
major
problem
in
food
production,
environmental
sustainability,
and
human
health.
The
cotton
bollworm
Helicoverpa
armigera
globally
distributed
crop
pest
affecting
over
300
species.
H.
has
rapidly
evolved
insecticide
resistance,
making
it
one
of
the
most
damaging
pests
worldwide.
Understanding
genetic
basis
provides
insights
to
develop
tools,
such
as
molecular
markers,
that
can
be
used
slow
or
prevent
evolution
resistance.
We
explore
architecture
widely
insecticide,
flubendiamide,
using
two
complementary
approaches:
genome-wide
association
studies
(GWAS)
wild-caught
samples
quantitative
trait
locus
(QTL)
mapping
controlled
cross
susceptible
resistant
laboratory
strains.
Both
approaches
identified
on
chromosome
2,
revealing
SNPs
within
976
bp
monitor
field
flubendiamide.
This
was
only
region
linkage
mapping,
though
GWAS
revealed
additional
sites
associated
with
Other
loci
by
populations
contained
known
detoxification
genes
from
ATP-binding
cassette
family,
ABCA1,
ABCA3,
ABCF2
MDR1.
Our
findings
an
oligogenic
architecture,
contrasting
previous
reports
monogenic
ryanodine
receptor
.
work
elucidates
evolving
will
contribute
developing
effective
management
strategies.
