Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(6), P. 2827 - 2841
Published: Feb. 3, 2023
In
order
to
develop
anthranilic
diamides
with
novel
chemotypes,
a
series
of
acrylamide
linkers
were
designed
and
synthesized.
The
results
preliminary
bioassays
indicated
that
compounds
monofluoroalkene
amide
linker
(Z-isomer)
exhibited
good
larvicidal
activity
against
lepidopteran
pests.
LC50
values
compound
A23
Mythimna
separata
Plutella
xylostella
1.44
3.48
mg·L-1,
respectively,
while
those
chlorantraniliprole
0.08
0.06
respectively.
Compound
also
the
same
level
lethal
potency
resistant
susceptible
strains
Spodoptera
frugiperda
at
50
mg·L-1.
similar
symptoms
as
in
test
larvae.
Comparative
molecular
field
analysis
was
conducted
demonstrate
structure-activity
relationship.
Central
neuron
calcium
imaging
experiments
potential
ryanodine
receptor
(RyR)
activators
activated
channels
both
endoplasmic
reticulum
cell
membrane.
Molecular
docking
suggested
had
better
binding
P.
RyR
than
chlorantraniliprole.
MM|GBSA
dG
bind
value
117.611
kcal·mol-1.
Monofluoroalkene
introduced
into
diamide
insecticides
for
first
time
brought
chemotype
insect
activators.
feasibility
fluoroalkenes
insecticide
fragments
explored.
Insect Science,
Journal Year:
2021,
Volume and Issue:
28(3), P. 639 - 648
Published: Jan. 1, 2021
Abstract
Spodoptera
frugiperda
(Lepidoptera:
Noctuidae)
is
a
widely
distributed
pest
of
corn.
Since
it
invaded
China
in
2018,
has
caused
serious
damage
to
local
corn
production.
Chlorantraniliprole,
an
anthranilic
diamide
insecticide,
been
used
control
lepidopteran
pests.
Tetrachloropyramid
new
allosteric
modulator
insecticide
developed
based
on
chlorantraniliprole,
so
similar
mechanism
and
insecticidal
effect.
In
this
study,
we
investigated
resistance
levels
chlorantraniliprole
tetrachloropyramid
S.
from
13
populations
China.
Among
the
tested,
relative
highest
occurred
Guangzhou
population,
most
susceptible
was
found
Wuhan
population.
The
lethal
dosage
LD
50
value
population
against
27.8‐fold
higher
than
that
Minimal
differences
were
observed
among
terms
sensitivity
tetrachloropyramid.
Heterozygous
mutations
at
I4734
site
ryanodine
receptor
(RyR)
found,
while
no
G4891
site.
detected
only
two
786
individuals
analyzed,
one
Qinzhou
other
Anshun
(frequency
below
2%
both
cases).
There
significant
expression
RyR
between
populations.
summary,
our
results
indicate
that:
(i)
low
insecticides
China;
(ii)
analyzed
are
not
by
or
.
Insect Biochemistry and Molecular Biology,
Journal Year:
2023,
Volume and Issue:
159, P. 103983 - 103983
Published: June 26, 2023
The
tomato
leafminer,
Tuta
absoluta,
is
an
invasive
crop
pest
that
has
evolved
resistance
to
many
of
the
insecticides
used
for
its
control.
To
facilitate
investigation
underpinning
mechanisms
in
this
species
we
generated
a
contiguous
genome
assembly
using
long-read
sequencing
data.
We
leveraged
genomic
resource
investigate
genetic
basis
diamide
insecticide
chlorantraniliprole
Spanish
strains
T.
absoluta
exhibit
high
levels
insecticide.
Transcriptomic
analyses
revealed
that,
these
strains,
not
associated
with
previously
reported
target-site
mutations
target-site,
ryanodine
receptor,
but
rather
marked
overexpression
(20-
>100-fold)
gene
encoding
UDP-glycosyltransferase
(UGT).
Functional
expression
UGT,
UGT34A23,
via
ectopic
Drosophila
melanogaster
demonstrated
it
confers
strong
and
significant
vivo.
resources
study
provide
powerful
further
research
on
absoluta.
Our
findings
will
inform
development
sustainable
management
strategies
important
pest.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(2), P. e0295928 - e0295928
Published: Feb. 23, 2024
The
fall
armyworm
(Spodoptera
frugiperda)
is
one
of
the
most
destructive
pests
corn.
New
infestations
have
been
reported
in
East
Hemisphere,
reaching
India,
China,
Malaysia,
and
Australia,
causing
severe
destruction
to
corn
other
crops.
In
Puerto
Rico,
practical
resistance
different
mode
action
compounds
has
cornfields.
this
study,
we
characterized
inheritance
chlorantraniliprole
flubendiamide
identified
possible
cross-resistance
cyantraniliprole
cyclaniliprole.
Rican
(PR)
strain
showed
high
levels
(RR50
=
2,762-fold)
96-fold).
an
autosomal
for
X-linked
flubendiamide.
trend
dominance
demonstrated
incompletely
recessive
trait
H1
(♂
SUS
×
♀
PR)
dominant
H2
(♀
♂
chlorantraniliprole.
PR
no
significant
presence
detoxification
enzymes
(using
synergists:
PBO,
DEF,
DEM,
VER)
chlorantraniliprole;
however,
SR
2.7
(DEM),
3.2
(DEF)
7.6
(VER)
indicated
role
esterases,
glutathione
S-
transferases
ABC
transporters
metabolism
low
(74-fold)
cyclaniliprole
(11-fold),
respectively.
Incomplete
recessiveness
might
lead
survival
heterozygous
individuals
when
decay
diamide
residue
occurs
plant
tissues.
These
results
highlight
importance
adopting
diverse
pest
management
strategies,
including
insecticide
rotating
manage
FAW
populations
Rico
continents.
