Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(3), P. 243 - 252

Published: May 22, 2025

Background. Internally displaced people (IDP) often face many problems, both physical and psychological. Anxiety depression inherent in IDP predict slow recovery increase the risk of post-traumatic stress disorder mortality. Dysfunction autonomic nervous system is combined with type 2 diabetes mellitus (T2DM) cardiac neuropathy (CAN). The aim study was to analyze peculiarities short-term heart rate variability (HRV) T2DM. Materials methods. looked at three groups: 16 practically healthy individuals (group 1, controls), patients T2DM subclinical CAN (Lviv region, group 2, n = 16) 3, 16). No clinical symptoms were detected patients, age, sex, duration T2DM, body mass index, HbA1c did not differ significantly (p > 0.05). Subclini­cal diagnosed according results cardiovascular reflex tests Composite Assessment Symptom Score 31. HRV lasting 5 min studied analyzed. Results. A statistically significant rise wase CAN. At same time, there a decrease median RR interval (mRR); percentage adjacent NN intervals that deviate from one another by more than 50 ms (pNN50%); levels high frequency power (HF) normalized unit (HFnorm). In CAN, compared further signifi­cant observed: 86.19 ± 82.30 [69.0; 121.0] bpm; mRR: 709.56 93.45 [496.0; 871.0] ms; root mean square successive differences between intervals: 17.56 9.06 [5.0; 41.0] pNN50%: 2.56 4.66 [0; 17] %; low (LF): 626.56 428.50 [156.0; 1358.0] ms2; HF: 143.81 111.68 [10.0; 363.0] HF total spectrum: 10.44 8.15 [2.0; 26.0], as well growth LF unit: 79.81 14.25 [54.0; 96.0] n.u.; very 47.50 18.69 [12.0; 86.0] %. Conclusions. It found went down, sympathetic component became much stronger. This indicates activation body’s adaptive reactions response stressful situations. use analysis can be cost-effective scientifically sound approach for early diagnosis data obtained become basis development effective prevention strategies, new methods timely therapy

Language: Английский

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Putative role of non‐invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly?

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(18), P. 19081 - 19090

Published: Aug. 17, 2023

Cancer is globally a disease of significant public health concern owing to its prevalence, and association with morbidity mortality. Thus, cost-effective treatments for cancer are important help reduce However, the current therapeutic options such as chemotherapy, radiotherapy, surgery may produce serious adverse events nausea, vomiting, fatigue, peripheral neuropathy, especially in long term. In addition, these not be well tolerated by elderly those who frail. The article aimed at discussing an alternative option, non-invasive vagus nerve stimulation (VNS), roles it plays pathology immunotherapy. VNS does this reducing oxidative stress via silent information regulator 1 (SIRT1); inhibiting inflammation both hypothalamic-pituitary-axis (HPA) release corticosteroid from adrenal gland, cholinergic anti-inflammatory pathway (CAP), increasing vagal activity which helps regulation cell proliferation, differentiation, apoptosis, metabolism, increase chance survival. Furthermore, complications due or postoperative ileus severity neuropathy induced improves cancer-related lymphopenia, quality life. These suggest that importance immunotherapy cannot overemphasized. Therefore, considering safety cost-effectiveness, option worth trying patients, combination other therapies.

Language: Английский

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Sympathetic Overactivity and Parasympathetic Impairment in Type 2 Diabetes: An Analysis of Cardiovascular Autonomic Functions

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Background Cardiovascular autonomic dysregulation is a known complication of Type 2 diabetes mellitus (T2DM), characterized by in heart rate (HR) and blood pressure (BP). These disruptions cardiovascular control can significantly influence the morbidity mortality associated with disease. Objectives This study aims to investigate how T2DM affects functions comparing responses HR, BP, specific function tests between group without diabetes. The research questions focus on assessing HR variability, baroreflex sensitivity, other parameters determine extent diabetic patients. Methods cross-sectional involved 200 adults, divided equally (n = 100) 100). exclusion criteria included diseases renal impairment. Data collection baseline characteristics such as age BMI. measures, including systolic (SBP), diastolic (DBP), were recorded after five-minute rest. Autonomic assessed sympathetic parasympathetic responses, cold pressor test isometric hand grip exercise test. statistical analysis was conducted using IBM SPSS Statistics for Windows, Version 25 (Released 2017; Corp., Armonk, New York, United States), focusing independent t-tests compare groups, considering p-values <0.05 significant. Potential confounding variables like BMI accounted ensure robust findings Results showed higher average (28.95 ± 5.60) compared (26.50 5.70) an increased resting (74.20 8.60 bpm vs. 69.30 9.10 bpm). SBP slightly (115.00 19.00 mmHg 114.50 8.90 mmHg), while DBP lower (71.50 10.70 72.80 6.70 mmHg). smaller increase (106.80 11.00 mmHg) larger (75.90 8.30 upon standing controls. indicated activity group, significant rises (133.70 10.30 (83.40 9.00 (SBP: 114.31 11.87 mmHg, DBP: 71.85 8.67 demonstrate marked differences groups. Conclusions demonstrates that impacts functions, patients showing altered BP indicative decreased activity. dysfunctions may heighten risk individuals. Our highlight importance monitoring managing reduce their complications. Further should underlying mechanisms effectiveness interventions improve this population.

Language: Английский

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Impaired Modulation of the Autonomic Nervous System in Adult Patients with Major Depressive Disorder

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1268 - 1268

Published: June 6, 2024

Patients with major depressive disorder (MDD) have an increased risk for cardiac events. This is partly attributed to a disbalance of the autonomic nervous system (ANS) indicated by reduced vagal tone and (relative) sympathetic hyperactivity. However, in most studies, heart rate variability (HRV) was only examined while resting. So far, it remains unclear whether dysbalance ANS patients MDD restricted resting or also evident during parasympathetic activation. The aim this study compare responses challenges that stimulated and, respectively, systems MDD. Forty-six (female 27 (58.7%), mean age 44 ± 17 years) 46 healthy controls 26 (56.5%), 20 underwent measurement time- frequency-dependent domains HRV at rest, standing (sympathetic challenge), slow-paced breathing (SPB, vagal, i.e., challenge). showed higher rate, HRV, diminished resting, standing, SPB compared controls. responded similarly extent modulation impaired MDD, who decrease but increase activity when switching from standing. Assessing changes activation via respective might serve as future biomarker help allocate therapies like biofeedback psychotherapy were recently found modulate tone.

Language: Английский

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Heart Rate Variability as a Potential Predictor of Response to Intranasal Esketamine in Patients with Treatment-Resistant Depression: A Preliminary Report

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4767 - 4767

Published: Aug. 14, 2024

Background: Esketamine has received approval as a nasal spray (ESK-NS) for treatment-resistant depression (TRD) and evidence from real-world investigations confirmed the effectiveness of ESK-NS, albeit with interindividual differences in response. Heart rate variability (HRV), defined fluctuation time interval between consecutive heartbeats, can be used to measure autonomic dysfunction psychiatric disorders its role been investigated diagnosis prognosis depression. Methods: This preliminary report aims evaluate HRV parameters their association treatment outcome 18 patients (55.6% males, 55.6 ± 9.39 years old) TRD treated target dose ESK-NS one month (mean dose: 80.9 9.05 mg). The Beck Depression Inventory (BDI) 3 min resting electrocardiogram were assess changes depressive symptoms measurements before after treatment. Results: Responders (n = 8, 44.5%; based on ≥30% BDI scores reduction) displayed lower values than non-responders at baseline (p 0.019), which increased 0.038). Receiver-Operating Characteristic (ROC) curves obtained logistic regression discriminative potential our sample (AUC 0.844). Conclusions: These observations suggest mutual interaction esketamine HRV, especially relation Further studies are required investigate electrophysiological profiles among predictors response allow personalized intervention strategies that still represent public health concern.

Language: Английский

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Emerging wearable technologies for multisystem monitoring and treatment of Parkinson’s disease: a narrative review

Frontiers in Network Physiology, Journal Year: 2024, Volume and Issue: 4

Published: Feb. 13, 2024

Parkinson’s disease (PD) is a chronic movement disorder characterized by variety of motor and nonmotor comorbidities, including cognitive impairment, gastrointestinal (GI) dysfunction, autonomic/sleep disturbances. Symptoms typically fluctuate with different settings environmental factors thus need to be consistently monitored. Current methods, however, rely on infrequent rating scales performed in clinic. The advent wearable technologies presents new avenue track objective measures PD comorbidities longitudinally more frequently. This narrative review discusses proposes emerging that can monitor manifestations motor, cognitive, GI, throughout the daily lives individuals. provide wholistic insight into real-time physiological versus pathological function potential better assess treatments during clinical trials allow physicians optimize treatment regimens. Additionally, this briefly examines novel applications wearables as therapy for patients.

Language: Английский

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Effect of Biofeedback-Based Interventions on the Psychological Outcomes of Pediatric Populations: A Systematic Review and Meta-analysis

Applied Psychophysiology and Biofeedback, Journal Year: 2023, Volume and Issue: 48(3), P. 299 - 310

Published: April 4, 2023

Language: Английский

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REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 29, 2023

Accumulating evidence suggests that rapid eye movement sleep (REM) supports the consolidation of extinction memory. REM is disrupted in PTSD, and abnormalities after traumatic events increase risk developing PTSD. Therefore, it was hypothesized abnormal trauma-exposed individuals may pave way for PTSD by interfering with processing In addition, patients display reduced vagal activity. Vagal activity contributes to strengthening memories, including fear memory, recent studies show role vagus memory extends during sleep. plausible be an additional mechanism impairs consolidation. However, date, contribution or any emotional has not been investigated. To test these hypotheses, we examined association characteristics (indexed as heart rate variability) a large sample (n=113). Consistent our disruption associated poorer physiological explicit Furthermore, higher better males. These findings support notion contribute impairing indicate potential utility interventions target fear-related disorders.

Language: Английский

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Mediating Effect of Heart Rate Variability on the Relationship Between Anxiety Symptoms and Blood Pressure in Patients with Primary Hypertension

Applied Psychophysiology and Biofeedback, Journal Year: 2024, Volume and Issue: 49(3), P. 473 - 482

Published: April 1, 2024

Language: Английский

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Interplay of age, gender, education, and heart rate in dementia among older adults in Wakiso, Uganda: a cross sectional study

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 448 - 448

Published: May 3, 2024

Background In this cross-sectional study conducted in Wakiso, Uganda, from May to July 2023, we investigated the interactions among age, sex, education, and heart rate relation dementia Mild Cognitive Impairment (MCI) individuals aged 65 years older. Methods We purposively sampled 106 participants, focusing on those with Alzheimer’s disease related dementias, leveraging collaborations local health teams. Data collection involved comprehensive questionnaires covering sociodemographic details parameters, employed Montreal Assessment Tool for screening. Results Our findings highlight a nuanced landscape of risk factors; each additional year age was associated 1.19- 1.22-times increased MCI dementia, respectively. Gender analysis revealed protective effect against males, but no significant impact risk. Education emerged as factor, 28% reduction risk, although its remains ambiguous. Significantly, an elevated strongly linked both underscoring potential cardiovascular dimension cognitive health. Conclusions This contributes understanding complex interplay factors emphasizing need further research elucidate underlying mechanisms interventions healthy aging older adult population.

Language: Английский

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