Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Science Advances, Journal Year: 2023, Volume and Issue: 9(20)
Published: May 17, 2023
Metastasis is the leading cause of cancer-related deaths; until now, detection tumor metastasis mainly located at period that secondary tumors have been formed, which usually results in poor prognosis. Thus, fast and precise positioning organs, where metastases are likely to occur its earliest stages, essential for improving patient outcomes. Here, we demonstrated a phosphorescence imaging method by organic nanoparticles detect early progress with microenvironmental changes, putting ahead formation tumors. In orthotopic simulated hematological models, changes could be recognized day 3, after implantation liver or intravenous injection cancer cells. It was far those other reported methods least 7 days later, providing sensitive convenient monitor stage.
Language: Английский
Citations
56
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 984 - 984
Published: Feb. 28, 2024
Anticancer drugs induce apoptotic and non-apoptotic cell death in various cancer types. The signaling pathways for anticancer drug-induced have been shown to differ between drug-sensitive drug-resistant cells. In atypical multidrug-resistant leukemia cells, the c-Jun/activator protein 1 (AP-1)/p53 pathway leading is altered. Cancer cells treated with undergo c-Jun/AP-1–mediated are involved c-Jun N-terminal kinase activation growth arrest- DNA damage-inducible gene 153 (Gadd153)/CCAAT/enhancer-binding homologous induction, regardless of p53 genotype. Gadd153 induction associated mitochondrial membrane permeabilization after drug treatment involves a coupled endoplasmic reticulum stress response. apoptosis by mediated intrinsic (cytochrome c, Cyt c) subsequent caspase cascade via proapoptotic genes (e.g., Bax Bcl-xS) their interactions. caspase-dependent caspase-independent occurs extrinsic pathways. targeting antiapoptotic such as Bcl-2 enhances efficacy. modulation Bcl-xS transduction increases sensitivity multidrug resistance-related protein-overexpressing epidermoid carcinoma drugs. significance autophagy therapy remains be elucidated. this review, we summarize current knowledge death-related alterations during discuss potential strategies enhance
Language: Английский
Citations
21
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504
Published: April 23, 2024
Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.
Language: Английский
Citations
21
iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109979 - 109979
Published: May 15, 2024
This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.
Language: Английский
Citations
19
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 6, 2024
Abstract Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing stark contrast to traditional approaches like small molecule inhibitors that primarily focus on inhibiting function. This advanced technology capitalizes the cell’s intrinsic proteolytic systems, including proteasome and lysosomal pathways, selectively eliminate disease-causing proteins. TPD not only enhances efficacy of treatments but also expands scope applications. Despite its considerable potential, faces challenges related properties drugs their rational design. review thoroughly explores mechanisms clinical advancements TPD, from initial conceptualization practical implementation, with particular proteolysis-targeting chimeras molecular glues. In addition, delves into emerging technologies methodologies aimed at addressing these enhancing efficacy. We discuss significant trials highlight promising outcomes associated drugs, illustrating potential transform treatment landscape. Furthermore, considers benefits combining other therapies enhance overall effectiveness overcome drug resistance. The future directions applications are explored, presenting an optimistic perspective further innovations. By offering comprehensive overview current innovations faced, this assesses transformative revolutionizing development setting stage for new era medical therapy.
Language: Английский
Citations
19
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Nasopharyngeal carcinoma (NPC) presents significant treatment challenges due to its complex etiology and late-stage diagnosis. The traditional Chinese medicine Selaginella doederleinii Hieron (S. doederleinii) has shown potentiality in NPC multi-target, multi-pathway anti-cancer mechanisms. First, we identified related target genes from databases like GeneCards, OMIM, DisGeNET, performed WGCNA analysis on the GSE53819 dataset identify several important gene modules NPC. Active components their targets S. were screened TCMSP other databases, identifying 32 overlapping genes. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway revealed that these are primarily involved critical biological processes protein phosphorylation cell cycle regulation. A protein–protein interaction network was constructed, cytoHubba six key (BCL2, MAPK14, ABCB1, PLK1, ATM, HMOX1). Kaplan–Meier immune infiltration further showed closely prognosis microenvironment patients. Single-cell RNA sequencing expression distribution across different types explored roles differentiation process malignant cells through pseudotime trajectory analysis. Molecular docking dynamics simulation results indicated Berberine-MAPK14 Matairesinol-PLK1 complexes have high binding affinity stability. Binding free energy calculations confirmed stability complexes. Based our comprehensive multi-level analysis, active may play a role multi-target synergistic effects.
Language: Английский
Citations
2
Cell investigation., Journal Year: 2025, Volume and Issue: 1(1), P. 100007 - 100007
Published: Jan. 30, 2025
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1954 - 1954
Published: Jan. 19, 2023
Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant is effective in treatment of colitis, hepatitis, pneumonia, respiratory infections, allergic diseases. This consists major active substances, such as baicalin, baicalein, wogonoside, wogonin. Inflammatory bowel disease (IBD) comprises a group inflammatory conditions the colon small intestine, Crohn's ulcerative colitis being main types. IBD can lead to serious complications, increased risk colorectal cancer (CRC), one most common cancers worldwide. Currently, there no cure for IBD, its incidence has been increasing over past few decades. review comprehensively summarizes efficacy SBG CRC may serve reference future research development drugs treatment.
Language: Английский
Citations
33
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115696 - 115696
Published: Oct. 12, 2023
Programmed cell death (PCD) is a key mechanism for the study of anticancer drugs and has significant impact on development management cancer. A growing amount data indicates that different kinds PCD, particularly pyroptosis, apoptosis, necroptosis, interact closely. Recent research revealed existence distinct inflammatory PCD modality known as PANoptosis, which controlled by complex PANoptosome complexes built combining elements from pathways. No single route sufficient to explain all physiologic effects seen in PANoptosis. Numerous studies have demonstrated PANoptosis can successfully stop cancer cells growing, proliferating, developing drug resistance. As result, it changed focus targeted therapy. In this review, we outlined molecular processes activation modulation well mechanisms innate immune death. order provide theoretical foundation targeting an anti-cancer target, also highlight PANoptosomes discovered date give overview implications treatment.
Language: Английский
Citations
26