Vascular Pharmacology, Journal Year: 2024, Volume and Issue: 157, P. 107439 - 107439
Published: Nov. 15, 2024
Language: Английский
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 250 - 262
Published: Aug. 5, 2024
Language: Английский
Citations
4
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Feb. 25, 2025
Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 7, 2025
Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation JAK/STAT pathway implicated promoting or inhibiting ferroptosis, depending on context. JAK2 promotes activating STAT proteins, modulating expression key regulators like SLC7A11 GPX4, influencing iron homeostasis through pathways such as ferritinophagy hepcidin regulation. STAT1 activation primarily enhances suppression cystine-glutamate antiporter (System Xc-), leading to glutathione depletion contributing conditions Sjogren's syndrome age-related macular degeneration. In contrast, STAT3 plays protective upregulating which inhibits survival, particularly cancers hepatocellular carcinoma, prostate renal carcinoma. also discusses STAT6's involvement diseases asthma lung injury regulating antioxidant defenses. Furthermore, review explores potential therapeutic strategies targeting manipulate for disease treatment. cancer therapy, this can enhance effectiveness inducers, offering promising avenues overcome drug resistance. Additionally, interplay immune responses, oxidative stress, metabolism underscores significance progression intervention. By exploring these mechanisms, provides insights into development novel treatments modulation, with implications inflammatory neurodegenerative conditions.
Language: Английский
Citations
0
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: March 1, 2025
Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.
Language: Английский
Citations
0
Postgraduate Medical Journal, Journal Year: 2025, Volume and Issue: unknown
Published: March 29, 2025
Currently, there is no definitive treatment for pulmonary hypertension (PH). This study aims to utilize the GEO database and conduct Mendelian randomization (MR) analysis identify new genetic targets PH investigate their potential pathogenic pathways therapeutic drugs. We identified key genes by combining findings from MR bioinformatics analyses of datasets. performed enrichment explore functional roles these genes. Then, we constructed protein-protein interaction (PPI) miRNA-mRNA networks interacting proteins miRNAs. Drug prediction was conducted propose Finally, validated results through dataset, RT-PCR, western blot experiments. The joint utilizing databases two genes, ITGA2B TSPAN9 that exhibited significance across both analytical methods. indicated were involved in critical biological functions pathways, including cell adhesion, platelet activation, PI3K-Akt signaling pathway. PPI further highlighted PH. revealed as targets. RT-PCR experiments above findings. By integrating analysis, found have a causal relationship with Our offer insights into molecular mechanism PH, establishing basis future research clinical applications.
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117706 - 117706
Published: Nov. 23, 2024
Language: Английский
Citations
1
Vascular Pharmacology, Journal Year: 2024, Volume and Issue: 157, P. 107439 - 107439
Published: Nov. 15, 2024
Language: Английский
Citations
0