Nonlinear Decline in the Association between Birth Weight and Cognitive Ability from Infancy to Midlife in a Community Sample of Twins DOI Open Access
Sean R. Womack, Christopher R. Beam, Evan J. Giangrande

et al.

Published: Oct. 26, 2023

Birth weight is a widely used indicator of prenatal experiences in models the developmental origins cognitive ability across lifespan. We modeled change strength association between birth and sample twins (n = 1,501; 53.1% female; 91.1% White) followed prospectively from infancy to midlife. The magnitude declined exponentially (B .59, p < .05) midlife .27, .05). A 1-kilogram increase was associated with an 8.85-point scores at 3 months 4.05-point advantage after about 2.5 years. Biometric regression revealed that shared environmental factors accounted for decline ability. small, positive within-pair persisted into Findings support origin

Language: Английский

Methods for the assessment of biological age – A systematic review DOI

Rebecca Zurbuchen,

Anna von Däniken,

Heidrun Janka

et al.

Maturitas, Journal Year: 2025, Volume and Issue: 195, P. 108215 - 108215

Published: Feb. 7, 2025

Language: Английский

Citations

1
Nonlinear Catch-Up Growth in Height, Weight, and Head Circumference from Birth to Adolescence: A Longitudinal Twin Study DOI
Sean R. Womack, Christopher R. Beam, Evan J. Giangrande

et al.

Behavior Genetics, Journal Year: 2023, Volume and Issue: 53(5-6), P. 385 - 403

Published: Aug. 27, 2023

Language: Английский

Citations

7
Stability of mental abilities and physical growth from 6 months to 65 years: Findings from the Zurich Longitudinal Studies DOI Creative Commons
Dominique A. Eichelberger, Fabio Sticca,

Dinah R. Kübler

et al.

Intelligence, Journal Year: 2023, Volume and Issue: 97, P. 101730 - 101730

Published: Feb. 9, 2023

Mental abilities and physical growth are important determinants of health across the lifespan. Here, stability these traits was assessed from 6 months to 65 years age investigate periods malleability. abilities, height, weight were at 11 time-points in participants Zurich Longitudinal Studies. Individuals with more than three missing data points per trait assessment (i.e., approx. 25% data) excluded further analyses (final N = 281). Bivariate cross-time correlations showed that mental low infancy gradually increased. The measures uniform development, height being highly stable moderately so. When a latent model used, overall approached weight. findings indicate malleability development differ between measures. This requires consideration interventions targeting as facilitators for improving outcomes.

Language: Английский

Citations

4
Genetically informed, multilevel analysis of the Flynn Effect across four decades and three WISC versions DOI
Evan J. Giangrande, Christopher R. Beam, Deborah Finkel

et al.

Child Development, Journal Year: 2021, Volume and Issue: 93(1)

Published: Nov. 11, 2021

Abstract This study investigated the systematic rise in cognitive ability scores over generations, known as Flynn Effect , across middle childhood and early adolescence (7–15 years; 291 monozygotic pairs, 298 dizygotic pairs; 89% White). Leveraging unique structure of Louisville Twin Study (longitudinal data collected continuously from 1957 to 1999 using Wechsler Intelligence Scale for Children [WISC], WISC–R, WISC–III ed.), multilevel analyses revealed between‐subjects Effects—as both decrease mean upon test re‐standardization increase cohorts—as well within‐child Effects on growth age. Overall gains equaled approximately three IQ points per decade. Novel genetically informed suggested that individual sensitivity was moderated by an interplay genetic environmental factors.

Language: Английский

Citations

10
Co‐recovery of physical size and cognitive ability from infancy to adolescence: A twin study DOI
Sean R. Womack, Christopher R. Beam, Evan J. Giangrande

et al.

Child Development, Journal Year: 2024, Volume and Issue: 95(4), P. 1367 - 1383

Published: Feb. 1, 2024

This study tested phenotypic and biometric associations between physical cognitive catch-up growth in a community sample of twins (n = 1285, 51.8% female, 89.3% White). Height weight were measured at up to 17 time points birth 15 years, ability was assessed 16 3 months years. Weight length positively associated with abilities infancy adolescence (r's .16-.51). More rapid slower, steadier growth. Shared nonshared environmental factors accounted for positive size outcomes. Findings highlight the role prenatal experiences co-development.

Language: Английский

Citations

1
Genetic and environmental correlates of the nonlinear recovery of cognitive ability in Twins. DOI Creative Commons
Sean R. Womack, Christopher R. Beam, Deborah Winders Davis

et al.

Developmental Psychology, Journal Year: 2021, Volume and Issue: 58(3), P. 535 - 550

Published: Dec. 9, 2021

Twins regularly score nearly a standard deviation below the population mean on standardized measures of cognitive development in infancy but recover to by early childhood, making rapid gains through toddler years. To date, only polynomial growth models have been fit model recovery across limiting applicability parameters later developmental periods. We nonlinear asymptotic Gompertz prospective scores from 1,153 individual twins 578 families (47.9% male, 91.5% White, 61.6% monozygotic) measured at 16 time points between 3 months and 15 displayed lower asymptote 86.47 (.90 SD mean) gained average 17.01 points, achieving an upper 103.48. Growth was observed be most 3.26 years, highlighting importance years development. Biometric analyses revealed that shared environmental factors accounted for majority variance initial ability as well ability. Gestational age family socioeconomic status (SES) were robust predictors growth. Results present study provide insight into processes underlying children evincing slight delays their In particular, findings highlight prenatal economic resources important aspects environment (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Language: Английский

Citations

7
Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study DOI Creative Commons
Briana Mezuk, Kristen Kelly,

Erica Bennion

et al.

Frontiers in Clinical Diabetes and Healthcare, Journal Year: 2023, Volume and Issue: 4

Published: March 17, 2023

Background Comorbidity between depression and type 2 diabetes is thought to arise from the joint effects of psychological, behavioral, biological processes. Studies monozygotic twins may provide a unique opportunity for clarifying how these processes inter-relate. This paper describes rationale, characteristics, initial findings longitudinal co-twin study aimed at examining biopsychosocial mechanisms linking risk in mid-life. Methods Participants Mood Immune Regulation Twins (MIRT) Study were recruited Mid-Atlantic Twin Registry. MIRT consisted 94 individuals who do not have baseline, representing 43 twin pairs (41 dizygotic), one set triplets, 5 whose did participate. A broad variables assessed including psychological factors (e.g., lifetime history major (MD)); social stress perceptions experiences); , indicators metabolic BMI, blood pressure (BP), HbA1c) immune functioning pro- anti-inflammatory cytokines), as well collection RNA. re-assessed 6-month later. Intra-class correlation coefficients (ICC) descriptive comparisons used explore variation social, across time within pairs. Results Mean age was 53 years, 68% female, 77% identified white. One-third had MD, 18 sibling sets discordant MD. MD associated with higher systolic (139.1 vs 132.2 mmHg, p=0.05) diastolic BP (87.2 vs. 80.8 p=0.002) IL-6 (1.47 0.93 pg/mL, p=0.001). HbA1c, or other markers. While characteristics co-twins significantly correlated, all within-person ICCs than within-pair correlations HbA1c ICC=0.88 ICC=0.49; ICC=0.64 within-pair=0.54). Among substantially markers, but positively stress. Conclusions studies potential clarify diabetes, recently completed processing RNA samples permits future exploration gene expression mechanism.

Language: Английский

Citations

2
Co-Recovery of Physical Size and Cognitive Ability from Infancy to Adolescence: A Twin Study DOI Open Access
Sean R. Womack, Christopher R. Beam, Evan J. Giangrande

et al.

Published: Oct. 17, 2023

This study tested phenotypic and biometric associations between physical cognitive catch-up growth in a community sample of twins (n = 1,285, 51.8% female, 89.3% White). Height weight were measured at up to 17 time points birth 15 years ability was assessed 16 3 months years. Weight length positively associated with abilities infancy adolescence (r’s .16-.51). More rapid slower, steadier growth. Shared nonshared environmental factors accounted for positive size outcomes. Findings highlight the role prenatal experiences co-development.

Language: Английский

Citations

1
Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review DOI Open Access
Alison Ziesel, Jennifer Reeves, Αναστασία Μαλλίδου

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Biological aging is a rapidly growing area of research, which entails characterizing the rate independent an individual’s chronological age. In this review, we analyze results biological research in 435 papers published twelve year window, revealing changing patterns molecular markers use over time, and development novel metrics aging. We further identify consistent discordant findings, as well areas potential future focusing on questions measurement with methylation or biomarker-based assessment other variables relevant to study

Language: Английский

Citations

0
The Relationship Between Biological Aging with Interdisciplinary Health Indicators: A Scoping Review DOI Creative Commons
Jennifer Reeves,

Emma Knock,

Zoë M. Gilson

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Abstract Objectives This review aims to provide a comprehensive examination of biomarkers and interdisciplinary variables related aging. Methods scoping included studies which involved adult participants, reported on the relationship between any biomarker or biological age with chronological age. Results After screening, 447 articles met selection criteria. were categorized into 10 distinct categories through an iterative process. Conclusions contributes information regarding influences rate Telomere length was most commonly examined biomarker, Horvath’s 353-CpG Pan-Tissue clock common clock, both demonstrating strong consistent The demonstrated relationships aging varying strengths consistencies.

Language: Английский

Citations

0