Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study DOI Creative Commons
Briana Mezuk, Kristen Kelly,

Erica Bennion

et al.

Frontiers in Clinical Diabetes and Healthcare, Journal Year: 2023, Volume and Issue: 4

Published: March 17, 2023

Background Comorbidity between depression and type 2 diabetes is thought to arise from the joint effects of psychological, behavioral, biological processes. Studies monozygotic twins may provide a unique opportunity for clarifying how these processes inter-relate. This paper describes rationale, characteristics, initial findings longitudinal co-twin study aimed at examining biopsychosocial mechanisms linking risk in mid-life. Methods Participants Mood Immune Regulation Twins (MIRT) Study were recruited Mid-Atlantic Twin Registry. MIRT consisted 94 individuals who do not have baseline, representing 43 twin pairs (41 dizygotic), one set triplets, 5 whose did participate. A broad variables assessed including psychological factors (e.g., lifetime history major (MD)); social stress perceptions experiences); , indicators metabolic BMI, blood pressure (BP), HbA1c) immune functioning pro- anti-inflammatory cytokines), as well collection RNA. re-assessed 6-month later. Intra-class correlation coefficients (ICC) descriptive comparisons used explore variation social, across time within pairs. Results Mean age was 53 years, 68% female, 77% identified white. One-third had MD, 18 sibling sets discordant MD. MD associated with higher systolic (139.1 vs 132.2 mmHg, p=0.05) diastolic BP (87.2 vs. 80.8 p=0.002) IL-6 (1.47 0.93 pg/mL, p=0.001). HbA1c, or other markers. While characteristics co-twins significantly correlated, all within-person ICCs than within-pair correlations HbA1c ICC=0.88 ICC=0.49; ICC=0.64 within-pair=0.54). Among substantially markers, but positively stress. Conclusions studies potential clarify diabetes, recently completed processing RNA samples permits future exploration gene expression mechanism.

Language: Английский

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism DOI Creative Commons

Bo Sun,

Xue‐Wei Cao,

Xin Ming

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 347 - 357

Published: Jan. 1, 2024

Abstract: Depression is a prevalent mental disorder and has profound impact on an individual's psychological physical well-being. It characterized by persistently depressed mood, loss of interest, energy loss, cognitive dysfunction. In recent years, more people have changed to diseases, such as depression, anxiety, mania so on. the incidence covering all ages, but still mainly young middle-aged women. Traditional treatments for depression rely medication psychotherapy, these methods are not effective patients often accompanied certain side effects. Therefore, finding safe alternative or adjuvant become priority. Here we highlight research progress acupuncture in treatment explore mechanism depression. Acupuncture ancient method, involves multiple biological pathways, example, regulating neurotransmitter levels, neuroendocrine axis, improving neuroplasticity, anti-inflammatory other effects, emotional state play antidepressant role. To provide evidence support widespread use clinical practice. We hope new ideas with even reduce Keywords: acupuncture,

Language: Английский

Citations

4
Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study DOI Creative Commons
Briana Mezuk, Kristen Kelly,

Erica Bennion

et al.

Frontiers in Clinical Diabetes and Healthcare, Journal Year: 2023, Volume and Issue: 4

Published: March 17, 2023

Background Comorbidity between depression and type 2 diabetes is thought to arise from the joint effects of psychological, behavioral, biological processes. Studies monozygotic twins may provide a unique opportunity for clarifying how these processes inter-relate. This paper describes rationale, characteristics, initial findings longitudinal co-twin study aimed at examining biopsychosocial mechanisms linking risk in mid-life. Methods Participants Mood Immune Regulation Twins (MIRT) Study were recruited Mid-Atlantic Twin Registry. MIRT consisted 94 individuals who do not have baseline, representing 43 twin pairs (41 dizygotic), one set triplets, 5 whose did participate. A broad variables assessed including psychological factors (e.g., lifetime history major (MD)); social stress perceptions experiences); , indicators metabolic BMI, blood pressure (BP), HbA1c) immune functioning pro- anti-inflammatory cytokines), as well collection RNA. re-assessed 6-month later. Intra-class correlation coefficients (ICC) descriptive comparisons used explore variation social, across time within pairs. Results Mean age was 53 years, 68% female, 77% identified white. One-third had MD, 18 sibling sets discordant MD. MD associated with higher systolic (139.1 vs 132.2 mmHg, p=0.05) diastolic BP (87.2 vs. 80.8 p=0.002) IL-6 (1.47 0.93 pg/mL, p=0.001). HbA1c, or other markers. While characteristics co-twins significantly correlated, all within-person ICCs than within-pair correlations HbA1c ICC=0.88 ICC=0.49; ICC=0.64 within-pair=0.54). Among substantially markers, but positively stress. Conclusions studies potential clarify diabetes, recently completed processing RNA samples permits future exploration gene expression mechanism.

Language: Английский

Citations

2