Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 3, 2025

Oxidative stress and neuroinflammation are recognized as key factors in the development of neurodegenerative diseases, yet effective interventions biomarkers to address oxidative these conditions limited. Uric acid (UA), traditionally associated with gout, is now gaining prominence a potential target diseases. Soluble UA stands out one most vital antioxidant compounds produced by human body, accounting for up 55% extracellular capacity neutralize free radicals. While there increasing evidence supporting neuroprotective properties Parkinson's disease Alzheimer's disease, gaps knowledge still exist regarding underlying mechanisms how effectively translate benefits into clinical practice. Moreover, current elevation therapy exhibits unstable properties, individual variability, even adverse effects, limiting its applications. This review consolidates recent advancements understanding exerts effects on diseases emphasizes dual roles managing neuroinflammation. Additionally, elucidates through which confers neuroprotection. Based this, underscores significance biomarker aims provide comprehensive therapeutic target, while also addressing possible challenges implementation.

Language: Английский

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Reactive Oxygen Species: Role in Pathophysiology, and Mechanism of Endogenous and Dietary Antioxidants during Oxidative Stress

Chonnam Medical Journal, Journal Year: 2025, Volume and Issue: 61(1), P. 32 - 32

Published: Jan. 1, 2025

Redox imbalances, which result from excessive production of reactive oxygen species (ROS) or malfunctioning the antioxidant system, are source oxidative stress. ROS affects all structural and functional components cells, either directly indirectly. In addition to causing genetic abnormalities, also oxidatively modifies proteins by protein oxidation peroxidation alters lipid structure via advanced lipoxidation, decreasing function promoting damage cell death. On other hand, low levels constitute important redox-signaling molecules in various pathways that maintain cellular homeostasis regulate key transcription factors. As a result, can affect processes, such as apoptosis, migration, differentiation, proliferation. act signaling molecules, controlling normal physiological activities at level. Furthermore, there is an increasing body evidence indicating role clinical conditions. this review, we will summarize pathological processes action during

Language: Английский

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Association between life’s essential 8 and biological ageing among US adults

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 14, 2023

Abstract Background Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of health (CVH), and biological ageing. Methods This cross-sectional study selected adults ≥ 20 years age from 2005–2010 National Health Nutrition Examination Survey. LE8 scores (range 0–100) were obtained measurements based on American Heart Association definitions, divided into behavior factor scores. was assessed by different methods including phenotypic age, acceleration (PhenoAgeAccel), (BioAgeAccel). Correlations analyzed weighted linear regression restricted cubic spline models. Results Of 11,729 participants included, mean 47.41 ± 0.36 5983 (51.01%) female. The ages 42.96 0.41 46.75 0.39 years, respectively, score 67.71 0.35. After adjusting for potential confounders, higher associated with lower PhenoAgeAccel, BioAgeAccel, nonlinear dose–response relationships. Negative associations also found ageing, stronger factors. In factor-specific analyses, β negativity greater blood glucose pressure. inverse correlations in stratified analyses remained solid across strata. Conclusions its subscale strongly negatively related Encouraging optimal CVH levels may be advantageous preventing slowing down

Language: Английский

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Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 147(1)

Published: May 9, 2024

Abstract Aging affects all cell types in the CNS and plays an important role diseases. However, underlying molecular mechanisms driving these age-associated changes their contribution to diseases are only poorly understood. The white matter aging brain as well diseases, such Multiple sclerosis is characterized by subtle abnormalities myelin sheaths paranodes, suggesting that oligodendrocytes, myelin-maintaining cells of CNS, lose capacity preserve a proper structure potentially function age certain Here, we made use directly converted oligodendrocytes (dchiOL) from young, adult old human donors study changes. dchiOL three groups differentiated comparable manner into O4 + immature but proportion MBP mature decreased with increasing donor age. This was associated increased ROS production upregulation cellular senescence markers CDKN1A, CDKN2A dchiOL. Comparison transcriptomic profiles revealed 1324 differentially regulated genes limited overlap donors’ fibroblasts or published data sets neurons primary rodent oligodendroglial lineage cells. Methylome analyses tissue samples demonstrate chronological epigenetic correlate resulted identification age-specific signature. Furthermore, observed accelerated myelinated, normal appearing multiple (MS) patients compared healthy individuals. Impaired differentiation could be induced young vitro using supernatants pro-inflammatory microglia. In summary, our suggest physiological inflammation-induced contribute pathology inflammatory demyelinating MS.

Language: Английский

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Cetuximab decorated redox sensitive D-alpha-tocopheryl- polyethyleneglycol-1000-succinate based nanoparticles for cabazitaxel delivery: Formulation, lung targeting and enhanced anti-cancer effects

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123881 - 123881

Published: Feb. 5, 2024

Language: Английский

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Chemisorption of Emerging Contaminants (F−, AsIII/V, Pb2+) Using MOF for Sustainable Water Treatment: A Critical Review

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Antioxidants and Mechanistic Insights for Managing Dry Age-Related Macular Degeneration

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 568 - 568

Published: May 4, 2024

Age-related macular degeneration (AMD) severely affects central vision due to progressive and its staggering prevalence is rising globally, especially in the elderly population above 55 years. Increased oxidative stress with aging considered an important contributor AMD pathogenesis despite multifaceted risk factors including genetic predisposition environmental agents. Wet can be managed routine intra-vitreal injection of angiogenesis inhibitors, but no satisfactory medicine has been approved for successful management dry form. The toxic carbonyls photo-oxidative degradation accumulated bisretinoids within lysosomes initiate a series events protein adduct formation, impaired autophagy flux, complement activation, chronic inflammation, which implicated AMD. Therapy based on antioxidants extensively studied promising effect reducing impact stress. This paper reviews pathogenesis, delineates effectiveness dietary nutrition supplements clinical studies, explores pre-clinical studies antioxidant molecules, extracts, formulations their mechanistic insights.

Language: Английский

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Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Introduction: Aged-related brain damage and gut microbiome disruption are common. Research affirms that modulating the microbiota-gut-brain axis can help reduce age-related damage. Methods: Ginseng, esteemed in traditional Chinese medicine, is recognized for its anti-aging capabilities. However, previous Ginseng studies have largely focused on diseased animal models. To this end, efforts were hereby made to explore potential neuroprotective effects of fecal microbiota transplantation (FMT) from Ginseng-supplemented aged mice those pre-treated with antibiotics. Results: As a result, FMT specific modifications natural aging improved weight gain, extended telomere length, anti-oxidative stress tissue, regulated serum levels cytokine, balanced proportion Treg cells. Besides, increased abundance beneficial bacteria Lachnospiraceae , Dubosiella Bacteroides etc. decreased pathogenic Helicobacter Lachnoclostridium samples mice. This revealed remarkably reshaped microbiome. Additionally, FMT-treated showed metabolites Ursolic acid, β-carotene, S-Adenosylmethionine, Spermidine, Guanosine, Celecoxib, Linoleic etc., which significantly positively correlated critical above. these identified mainly enriched pathways Amino acid metabolism, Lipid Nucleotide Furthermore, downregulated p53/p21/Rb signaling upregulated p16/p14, ATM/synapsin I/synaptophysin/PSD95, CREB/ERK/AKT following aging. Discussion: Overall, study demonstrates reprogramming by impedes process, possibly through regulation axis.

Language: Английский

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Pyridoxal-5-phosphate mitigates age-related metabolic imbalances in the rat heart through the H2S/AKT/GSK3β signaling axis

Mitochondrion, Journal Year: 2025, Volume and Issue: unknown, P. 102001 - 102001

Published: Jan. 1, 2025

Language: Английский

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Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 254 - 254

Published: Feb. 1, 2025

Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD⁺) and NADPH. NAD⁺ integral numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, senescence, aging. NAM supplementation has demonstrated efficacy in restoring energy, repairing damage, inhibiting inflammation by suppressing pro-inflammatory cytokines release. Due its natural presence variety foods excellent safety profile—even at high doses up 3 g/day—NAM extensively used chemoprevention non-melanoma skin cancers treatment dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, acne vulgaris. Recently, anti-aging properties have elevated NAM’s prominence skincare formulations. Beyond repair energy replenishment, significantly impacts oxidative stress reduction, cell cycle apoptosis modulation. Despite these multifaceted benefits, comprehensive molecular mechanisms underlying actions remain not fully elucidated. This review consolidates recent research shed light on mechanisms, emphasizing critical role health therapeutic potential. By enhancing our understanding, this work underscores importance continued exploration into applications, aiming inform future clinical practices innovations.

Language: Английский

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