Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis DOI Creative Commons

Nuria Renata Roldán-Bretón,

Adriana Guadalupe Capuchino-Suárez,

María Esther Mejía-León

et al.

Journal of Nutritional Science, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 1, 2023

The nutritional status is a determinant of the immune response that promotes cellular homeostasis. In particular, adequate selenium levels lead to better antioxidant and response. aim this work assess whether blood levels, at time SARS-CoV-2 infection, have an impact on development severity COVID-19. A systematic review meta-analysis comparative descriptive studies using MeSH terms, COVID-19 was performed. We searched bibliographic databases up 17 July 2022 in PubMed ScienceDirect. Studies reported data were considered. total 629 articles examined by abstract title, which 595 abstracts read, 38 included 11 meta-analysis. Meta-analysis conducted mean difference (MD) with 95 % confidence interval (CI), heterogeneity tested I2 random factors MD between mortality, morbidity healthy subjects P-value 0⋅05. Selenium higher people compared those patients disease (six studies, effects MD: test for overall effect Z = 3⋅28 (P 0⋅001), 97 CI 28⋅36 (11⋅41-45⋅31), P < 0⋅00001), but without when degree mild, moderate or severe cases. conclusion, active infection had lower than population. More are needed evaluate its clinical through randomised trials.

Language: Английский

Zinc Deficiency Associated With an Increase in Mortality in COVID-19 Patients: A Meta-Analysis DOI Open Access

Chirag Raval,

Spencer Z Rheingold,

Antonio M. Gordon

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The exact role of zinc in COVID-19-infected patients is not well understood. We examined the effects and outcomes deficiency on patients. focused patient outcomes: severity, symptomatology, mortality. meta-analysis was performed to examine whether individuals suffered greater symptomology Secondary explored included severity hospital length stay. For mortality, we found that with had a risk mortality than without (risk ratio (RR)=5.77; 95% confidence interval (CI): 3.48, 9.54; p=0.004). symptomology, symptomatology (RR=1.39; CI: 1.13, 1.70; p=0.020). Zinc-deficient are at for symptomatology. Our findings further reinforce importance supplementation as prophylactic agent against viral infections such COVID-19.

Language: Английский

Citations

3
Understanding the Role of Free Radicals and Antioxidant Enzymes in Human Diseases DOI
Nidhee Chaudhary, Zinal Roy, R.K. Bansal

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2022, Volume and Issue: 24(10), P. 1265 - 1276

Published: Nov. 22, 2022

Abstract: Antioxidant enzymes being an integral part of the defense mechanism have a crucial role in cellular metabolism, essential for healthy growth and living cells. The main function is to scavenge degrade free radicals, reactive oxygen species (ROS), nitrogen (RNS). Endogenous antioxidant present mitochondria, cytosol, other parts participate capturing repairing oxidative damage system. Superoxide dismutase, catalase, glutathione are considered be first line especially important scavenging such as superoxide anion hydrogen peroxide. Numerous studies humans, well animal models, correlated reported about elevation enzymatic activity involved inhibiting controlling disease progression. Similarly, alterations due increase key progression diseases like cancer, atherosclerotic diseases, neurodegenerative Parkinson’s, Alzheimer’s, viral age-related ailments, etc. However, information enzymes, their specificity, radicals different oxidation process needs explored greater extent. This review focuses on our current understanding potential various great scope therapeutics against many dreadful diseases.

Language: Английский

Citations

52
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review DOI Creative Commons

Hendrik Schmieder,

Christian Leischner,

Alban Piotrowsky

et al.

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 17, 2025

Abstract The importance of vitamin D for a well-functioning immune system is becoming increasingly evident. Nevertheless, the other fat-soluble vitamins A, E and K also seem to play central role regarding adequate function cells counteract excessive reactions inflammatory processes. However, recognizing hidden hunger, particularly micronutrient deficiencies in vulnerable groups like elderly, crucial because older adults often lack sufficient micronutrients various reasons. This review summarizes latest findings on modulating functions physiological pathophysiological context, provides graphical comparison Recommended Daily Allowances between Deutschland, Austria, Confoederatio Helvetica (D-A-CH; eng. GSA, Germany, Switzerland, Austria), Deutsche Gesellschaft für Ernährung (DGE; German Nutrition Society) National Institutes Health (NIH) across all age and, particular, addresses question benefits supplementation respective aging population industrialized nations strengthen system. following highlights D, which critical roles maintaining some cases, preventing activation. Therefore, better understanding relevance blood levels consequently potential strategies may contribute prevention management infectious diseases as well overall health elderly.

Language: Английский

Citations

1
Immunomodulatory Role of Microelements in COVID-19 Outcome: a Relationship with Nutritional Status DOI Open Access
Roldán-Bretón Nuria Renata, Anna González-Rascón, Ana Gabriela Leija-Montoya

et al.

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(4), P. 1596 - 1614

Published: June 6, 2022

Language: Английский

Citations

19
Zinc and selenium status in coronavirus disease 2019 DOI Open Access

Liding Fan,

Yanshuo Cui,

Zonghao Liu

et al.

BioMetals, Journal Year: 2023, Volume and Issue: 36(5), P. 929 - 941

Published: April 20, 2023

Language: Английский

Citations

11
Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study DOI
Fábio Fernandes Neves, Henrique Pott,

Kaori Maria Carolina Yamashita

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 207, P. 194 - 199

Published: July 15, 2023

Language: Английский

Citations

11
Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity DOI Creative Commons
Ying Zhou, Shuofeng Yuan, Fan Xiao

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(38), P. 10570 - 10579

Published: Jan. 1, 2023

Uncovering how host metal(loid)s mediate the immune response against invading pathogens is critical for better understanding pathogenesis mechanism of infectious disease. Clinical data show that imbalance closely associated with severity and mortality COVID-19. However, it remains elusive metal(loid)s, which are essential elements all forms life multiple diseases if dysregulated, involved in COVID-19 pathophysiology immunopathology. Herein, we built up a metal-coding assisted multiplexed serological metallome immunoproteome profiling system to characterize links immunity. We found distinct features patients compared non-infected control subjects, may serve as biomarker disease diagnosis. Moreover, generated first correlation network between immunity mediators, unbiasedly uncovered strong association selenium interleukin-10 (IL-10). Supplementation cells resulted enhanced IL-10 expression B reduced induction proinflammatory cytokines CD4+ T cells. The selenium-enhanced production was confirmed be attributable activation ERK Akt pathways. further validated our cellular SARS-CoV-2-infected K18-hACE2 mice, supplementation alleviated SARS-CoV-2-induced lung damage characterized by decreased alveolar inflammatory infiltrates through restoration virus-repressed selenoproteins alleviate oxidative stress. Our approach can readily extended other understand defends regulation metallome.

Language: Английский

Citations

11
Long-Term Effects of SARS-CoV-2 Infection on Metal Homeostasis DOI
Luyao Zhang, Fang Li, Xiaoxiong Liu

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127625 - 127625

Published: Feb. 27, 2025

Language: Английский

Citations

0
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2 DOI Open Access
Rajkumar Chakraborty, Gourab Bhattacharje, Joydeep Baral

et al.

Computers in Biology and Medicine, Journal Year: 2022, Volume and Issue: 147, P. 105788 - 105788

Published: June 30, 2022

Language: Английский

Citations

16
Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe DOI Creative Commons
Kamil Demircan, Thilo Samson Chillon,

Tommy Bracken

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 28, 2022

Introduction Certain trace elements are essential for life and affect immune system function, their intake varies by region population. Alterations in serum Se, Zn Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs correlates risk different countries Europe. Methods Serum samples from 551 patients (including 87 non-survivors) who had participated observational studies Europe (Belgium, France, Germany, Ireland, Italy, Poland) were analyzed total reflection X-ray fluorescence. A subset (n=2069) of European EPIC study served as reference. Analyses performed blinded to clinical data one analytical laboratory. Results Median levels Se lower than EPIC, except Italy. Non-survivors consistently concentrations survivors displayed an elevated Cu/Zn ratio. Restricted cubic spline regression models revealed inverse nonlinear association between or death, positive ratio death. With respect patient age sex, showed highest predictive value death (AUC=0.816), compared (0.782) (0.769). Discussion The support potential relevance decrease survival across design cannot account residual confounding reverse causation, but supports need intervention trials severe deficiency test benefit correcting deficits convalescence.

Language: Английский

Citations

16