Au–Cu Janus Nanostructures as NIR-II Photothermal Antibacterial Agents DOI
Qiuping Yang,

Haixia Kong,

L.J. Tang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20783 - 20792

Published: Aug. 20, 2024

Metal nanoparticles have been found to exhibit a broad spectrum of antibacterial activities, yet not all metals possess the captivating plasmonic properties necessary for effective interaction with incident light. In this study, we demonstrate feasibility synergistically enhancing Cu-induced activity through incorporation photothermal therapy by hybridlike anchoring Cu component on gold (Au) nanoplate that can effectively absorb near-infrared To fabricate Janus structure, plate-like Au seeds were mixed copper(ii) nitrate, cetyltrimethylammonium bromide, ascorbic acid, and hexamethylenetetramine, resulting in formation Au–Cu nanostructures (JNSs). Notably, absorption was preserved without being hindered coating. Photothermal measurements revealed temperature rise JNSs aqueous suspensions could reach up 28.3 °C just 10 min when exposed 1064 nm laser light at power density 1 W·cm–2, conversion efficiency 42.14%. Additionally, they show broad-spectrum properties, making them potential contenders addressing wide range bacterial infections. Our findings performance metal composed less plasmon-active components but exceptional be significantly enhanced coupling nano-antenna architecture. The application prospects therapy, treatments, biomedical imaging, targeted drug delivery, sensitive diagnostics, development advanced materials.

Language: Английский

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity DOI Creative Commons
Kishan Nandi Shoudho, Shihab Uddin, Md. Mahamudul Hasan Rumon

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(31), P. 33303 - 33334

Published: July 25, 2024

The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving

Language: Английский

Citations

14
Laser ablation in liquids: A versatile technique for nanoparticle generation DOI
Mohamed E. Shaheen,

Abdalla Y.E. Abdelwahab

Optics & Laser Technology, Journal Year: 2025, Volume and Issue: 186, P. 112705 - 112705

Published: March 4, 2025

Citations

0
The Composition of the Dispersion Medium Determines the Antibacterial Properties of Copper (II) Oxide Nanoparticles Against Escherichia coli Bacteria DOI Creative Commons
Olga V. Zakharova, Alexander Gusev, Peter A. Baranchikov

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(6), P. 469 - 469

Published: March 20, 2025

Copper (II) oxide nanoparticles (CuO NPs) attract much attention as a promising antimicrobial agent. We studied the antibacterial properties of three types CuO NPs against Escherichia coli bacteria: flake-shaped particles with diameter 50–200 nm and thickness 10–20 (CuO-CD synthesized by chemical deposition), spherical size 20–90 (CuO-EE obtained electrical explosion), rod-shaped length 100–200 30 × 70 (CuO-CS commercial sample). tested how shape, size, concentration NPs, composition dispersion medium affected NPs. prepared dispersions based on distilled water, 0.9% NaCl solution, LB broth Lennox used Triton X-100 sodium dodecyl sulfate (SDS) stabilizers. The was 1–100 mg L−1. showed that stabilizer type had greatest influence effects observed maximum effect for all NP dispersed in water without stabilizer, well SDS stabilizer. inhibition culture growth under CuO-EE (by 30%) 1.3–1.8 times depending particles). In saline were minimal; some cases, even promoted bacterial growth. increased but decreased them water. Finally, among particle types, CuO-CS turned out to be most bactericidal, which is probably due their morphology small diameter. At same time, aggregation colloidal systems we did not have linear action properties. These results can development coatings preparations achieve efficiency, taking into account expected conditions use.

Language: Английский

Citations

0
Nanomaterials-driven in situ vaccination: a novel frontier in tumor immunotherapy DOI Creative Commons

Naimeng Liu,

Xiangyu Wang,

Zhongzhao Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 17, 2025

In situ vaccination (ISV) has emerged as a promising strategy in cancer immunotherapy, offering targeted approach that uses the tumor microenvironment (TME) to stimulate an immune response directly at site. This method minimizes systemic exposure while maintaining therapeutic efficacy and enhancing safety. Recent advances nanotechnology have enabled new approaches ISV by utilizing nanomaterials with unique properties, including enhanced permeability, retention, controlled drug release. employing can induce immunogenic cell death reverse immunosuppressive hypoxic TME, thereby converting "cold" into "hot" facilitating more robust response. review examines mechanisms through which nanomaterials-based enhances anti-tumor immunity, summarizes clinical applications of these strategies, evaluates its capacity serve neoadjuvant therapy for eliminating micrometastases early-stage patients. Challenges associated translation ISV, nanomaterial metabolism, optimization treatment protocols, integration other therapies such radiotherapy, chemotherapy, photothermal therapy, are also discussed. Advances immunotherapy continue expand possible potentially leading improved outcomes across broad range types.

Language: Английский

Citations

0
Immunomodulatory Antibacterial Hydrogel for Wound Infection Management DOI Creative Commons
Jing Han,

Qingxun Meng,

T. Thomas Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8159 - 8174

Published: Aug. 1, 2024

Wound healing has always been a focal point in clinical work. Bacterial infections and immune microenvironment disorders can both hinder normal wound healing. Current dressings only serve covering function. Developing with antibacterial immunomodulatory functions is crucial for aiding To address this issue, we have developed hydrogel managing infected wounds.

Language: Английский

Citations

2
Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery DOI Creative Commons
Nicolae‐Viorel Buchete, Iwona Cicha, Sutapa Dutta

et al.

Frontiers in Drug Delivery, Journal Year: 2024, Volume and Issue: 4

Published: March 4, 2024

A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy nanosystem-based intravascular delivery (IVDD). Computational model development stems from vision replacing conventional (pre)clinical trials with advanced simulations and applies to more efficient for therapies. To establish a standardized framework preclinical trials, it is necessary include that each experimental stage trial respective nanocarrier system give accurate verifiable results. This review paper highlights status discusses stages physics-based multiscale should be developed, validated exploited address need an effective assessment IVDD.

Language: Английский

Citations

1
Ultra-small copper oxide with peroxidase-like activity for colorimetric detection of doxorubicin in chicken and fish DOI

Zhigang Ding,

Xiaoqing Chu,

Wei Fan

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 132, P. 106282 - 106282

Published: April 26, 2024

Language: Английский

Citations

1
Expression profiling of antimicrobial peptides and immune-related genes in Nile tilapia following Pseudomonas putida infection and nano-titanium dioxide gel exposure DOI
Heba H. Mahboub, Morteza Yousefi, Hosny Ahmed Abdelgawad

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 156, P. 110037 - 110037

Published: Nov. 20, 2024

Language: Английский

Citations

1
Au–Cu Janus Nanostructures as NIR-II Photothermal Antibacterial Agents DOI
Qiuping Yang,

Haixia Kong,

L.J. Tang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20783 - 20792

Published: Aug. 20, 2024

Metal nanoparticles have been found to exhibit a broad spectrum of antibacterial activities, yet not all metals possess the captivating plasmonic properties necessary for effective interaction with incident light. In this study, we demonstrate feasibility synergistically enhancing Cu-induced activity through incorporation photothermal therapy by hybridlike anchoring Cu component on gold (Au) nanoplate that can effectively absorb near-infrared To fabricate Janus structure, plate-like Au seeds were mixed copper(ii) nitrate, cetyltrimethylammonium bromide, ascorbic acid, and hexamethylenetetramine, resulting in formation Au–Cu nanostructures (JNSs). Notably, absorption was preserved without being hindered coating. Photothermal measurements revealed temperature rise JNSs aqueous suspensions could reach up 28.3 °C just 10 min when exposed 1064 nm laser light at power density 1 W·cm–2, conversion efficiency 42.14%. Additionally, they show broad-spectrum properties, making them potential contenders addressing wide range bacterial infections. Our findings performance metal composed less plasmon-active components but exceptional be significantly enhanced coupling nano-antenna architecture. The application prospects therapy, treatments, biomedical imaging, targeted drug delivery, sensitive diagnostics, development advanced materials.

Language: Английский

Citations

0