Lead and cadmium exposure was associated with faster epigenetic aging in a representative sample of adults aged 50 and older in the United States
Chemosphere,
Journal Year:
2025,
Volume and Issue:
374, P. 144194 - 144194
Published: Feb. 12, 2025
Language: Английский
Role of kidney function in mediating the relationship between heavy metal exposure and all-cause mortality in older adults
Yan Song,
No information about this author
Li He,
No information about this author
Li Zhang
No information about this author
et al.
Human and Ecological Risk Assessment An International Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: Jan. 5, 2025
Heavy
metal
exposure
has
well-established
health
risks,
but
its
impact
on
all-cause
mortality
through
renal
function
remains
unclear.
This
study
used
data
from
1,342
participants
aged≥60
years
in
the
National
Health
and
Nutrition
Examination
Survey
(2005-2018).
A
cross-sectional
design
was
employed,
with
heavy
composite
scores
derived
using
least
absolute
shrinkage
selection
operator
regression.
Multivariate
Cox
proportional
hazards
models
assessed
relationship
between
mortality,
while
mediation
analysis
evaluated
role
of
estimated
glomerular
filtration
rate
(eGFR).
The
average
participant
age
69.4
years.
Higher
(CMES)
were
associated
older
age,
higher
smoking
rates,
increased
blood
lead
(Pb)
cadmium
(Cd)
levels.
CMES
significantly
(adjusted
HR=1.75,
95%
CI:1.04-2.96),
Kaplan-Meier
curves
showing
lower
survival
(p=0.02).
Pb
Cd
levels
independently
risk.
eGFR
negatively
correlated
HR=0.98,
CI:
0.97-0.99)
mediated
23.7%
CMES-mortality
relationship.
These
findings
suggest
that
increases
risk,
partly
impaired
function.
Language: Английский
Association of longitudinal body mass index trajectories with phenotypic age acceleration: a cross-sectional study based on growth mixture modeling
Yalan Liu,
No information about this author
Li Zhang,
No information about this author
Zhaofeng Jin
No information about this author
et al.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Language: Английский
Associations between urinary and blood heavy metal exposure and heart failure in elderly adults: Insights from an interpretable machine learning model based on NHANES (2003-2020)
International Journal of Cardiology Cardiovascular Risk and Prevention,
Journal Year:
2025,
Volume and Issue:
unknown, P. 200418 - 200418
Published: May 1, 2025
Language: Английский