International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6336 - 6336
Published: March 28, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
the
primary
reason
for
cancer-related
deaths
in
US.
Genetic
mutations,
drug
resistance,
involvement
of
multiple
signaling
pathways,
cancer
stem
cells
(CSCs),
and
desmoplastic
stroma,
which
hinders
penetrance,
contribute
to
poor
chemotherapeutic
efficacy.
Hence,
there
a
need
identify
novel
drugs
with
improved
delivery
improve
treatment
outcomes.
Curcumin
one
such
compound
that
can
inhibit
pathways
CSCs.
However,
curcumin’s
clinical
applicability
treating
PDAC
limited
because
its
solubility
water
metabolic
instability.
we
developed
difluorinated
curcumin
(CDF)
analog
accumulates
selectively
pancreas
inhibits
growth
vitro
vivo.
In
present
work,
2-hydroxy-propyl-β-cyclodextrin
(HCD)
inclusion
complex
increase
hydrolytic
stability.
The
CDFHCD
was
characterized
by
spectroscopic,
thermal,
microscopic
techniques.
exhibited
increased
aqueous
solubility,
stability,
antiproliferative
activity
compared
parent
CDF.
Moreover,
CDF
inhibited
colony
spheroid
formation,
induced
cell
cycle
apoptosis
lines.
self-assembly
an
efficient
approach
anticancer
therapeutic
efficacy,
now
warrants
advancement
towards
proof
concept
patients.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(38), P. 9435 - 9458
Published: Jan. 1, 2024
Nanomedicine
has
inspired
a
ground-breaking
strategy
for
cancer
therapy.
By
intelligently
assembling
diverse
moieties
to
form
nanoparticles,
numerous
functionalities
such
as
controlled
release,
synergistic
efficiency,
and
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2830 - 2830
Published: March 21, 2025
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
the
third
leading
cause
of
cancer-related
death.
Its
poor
prognosis
closely
related
to
late-stage
diagnosis,
which
results
from
both
nonspecific
symptoms
and
absence
biomarkers
for
early
diagnosis.
MicroRNAs
(miRNAs)
exert
a
regulatory
role
in
numerous
biological
processes
their
aberrant
expression
has
been
found
broad
spectrum
diseases,
including
cancer.
Cancer
stem
cells
(CSCs)
represent
driving
force
PDAC
initiation,
progression,
metastatic
spread.
Our
previous
research
highlighted
interesting
behavior
miR-216a-5p
miR-125a-5p
progression
CSC
phenotype.
The
present
study
aimed
evaluate
effect
on
acquisition
or
suppression
pancreatic
traits.
BxPC-3,
AsPC-1
cell
lines,
CSC-like
models
were
transfected
with
mimics
inhibitors.
Following
transfection,
we
evaluated
impact
surface
markers
(CD44/CD24/CxCR4),
ALDH1
activity,
pluripotency-
EMT-related
gene
expression,
clonogenic
potential.
show
that
enhances
CD44/CD24/CxCR4
while
negatively
affecting
activity
EMT
genes.
MiR-216a-5p
positively
influenced
property.
MiR-125a-5p
promoted
inhibiting
activity.
It
enhanced
Snail,
Oct-4,
Sox-2,
potential
appeared
be
affected.
Comprehensively,
our
provide
further
knowledge
miRNAs
CSCs.
Moreover,
they
corroborate
findings
about
miR-216a-5p’s
dual
miR-125a-5p’s
promotive
function
PDAC.
Cancers,
Journal Year:
2022,
Volume and Issue:
15(1), P. 249 - 249
Published: Dec. 30, 2022
Phytochemicals
possess
various
intriguing
pharmacological
properties
against
diverse
pathological
conditions.
Extensive
studies
are
on-going
to
understand
the
structural/functional
of
phytochemicals
as
well
molecular
mechanisms
their
therapeutic
function
disease
such
curcumin
(Cur),
genistein
(Gen),
and
tanshinone-IIA
(Tan
IIA)
have
multifaceted
potentials
efforts
in
progress
dynamics
with
different
tools
technologies.
Cur
is
an
active
lipophilic
polyphenol
pleiotropic
function,
it
has
been
shown
including
antioxidant,
anti-inflammatory,
anti-microbial,
anticancer,
anti-genotoxic
besides
others
beneficial
properties.
Similarly,
Gen
(an
isoflavone)
exhibits
a
wide
range
vital
functions
pro-apoptotic,
anti-proliferative,
anti-angiogenic
activities
etc.
In
addition,
Tan
IIA,
compound,
possesses
anti-angiogenic,
anticancer
activities,
so
on.
Over
last
few
decades,
field
proteomics
garnered
great
momentum
mainly
attributed
recent
advancement
mass
spectrometry
(MS)
techniques.
It
envisaged
that
technology
considerably
contributed
biomedical
research
endeavors
lately.
Interestingly,
they
also
explored
reliable
approach
intricacies
related
phytochemical-based
interventions.
The
present
review
provides
overview
performed
unravel
underlying
Cur,
Gen,
IIA.
This
in-depth
study
will
help
researchers
better
understanding
potential
at
level.
Certainly,
this
be
highly
instrumental
catalyzing
translational
shift
from
clinical
practice
near
future.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6336 - 6336
Published: March 28, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
the
primary
reason
for
cancer-related
deaths
in
US.
Genetic
mutations,
drug
resistance,
involvement
of
multiple
signaling
pathways,
cancer
stem
cells
(CSCs),
and
desmoplastic
stroma,
which
hinders
penetrance,
contribute
to
poor
chemotherapeutic
efficacy.
Hence,
there
a
need
identify
novel
drugs
with
improved
delivery
improve
treatment
outcomes.
Curcumin
one
such
compound
that
can
inhibit
pathways
CSCs.
However,
curcumin’s
clinical
applicability
treating
PDAC
limited
because
its
solubility
water
metabolic
instability.
we
developed
difluorinated
curcumin
(CDF)
analog
accumulates
selectively
pancreas
inhibits
growth
vitro
vivo.
In
present
work,
2-hydroxy-propyl-β-cyclodextrin
(HCD)
inclusion
complex
increase
hydrolytic
stability.
The
CDFHCD
was
characterized
by
spectroscopic,
thermal,
microscopic
techniques.
exhibited
increased
aqueous
solubility,
stability,
antiproliferative
activity
compared
parent
CDF.
Moreover,
CDF
inhibited
colony
spheroid
formation,
induced
cell
cycle
apoptosis
lines.
self-assembly
an
efficient
approach
anticancer
therapeutic
efficacy,
now
warrants
advancement
towards
proof
concept
patients.
