A future avenue of treatment ulcerative colitis targeting macrophage polarization: A phytochemical Application DOI Creative Commons

Nishant Kumar Saurabh,

Mohd Mabood Khan, Annet Kirabo

et al.

Crohn s & Colitis 360, Journal Year: 2024, Volume and Issue: 6(4)

Published: Oct. 1, 2024

Abstract Background Ulcerative colitis (UC) is a prevalent inflammatory bowel disease primarily impacting the mucosa of colon. It characterized by recurring and incurable symptoms causes immense suffering significant economic burden due to limited treatment options. Typical UC include diarrhea, alterations in patterns, bleeding from rectum, rectal pain or urgency, anemia, tiredness. Therefore, developing novel effective strategies for imperative. Purpose This review aimed explain how macrophage polarization contributes development compiled information on natural compounds with promising therapeutic potential that can target phenotype shed light its mode action. Results The phenotypic alteration macrophages profoundly affects UC, these cells are essential preserving intestinal immunological homeostasis. Evidence research suggests one method prevention therapy guide toward M2 phenotype. Phytochemicals, which extracted plants, possess wide array biological activities. For example: Ginsenoside Rg1 emerges as crucial regulator polarization, promoting while inhibiting M1 Notably, their low toxicity high effectiveness render them candidates interventions. These have demonstrated encouraging protective effects against inflammation Conclusions Exploring phytochemicals avenue targeting presents an innovative approach treating UC.

Language: Английский

A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals DOI Creative Commons
Ke Wang, Tangyou Mao, Xinyu Lu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 1, 2023

Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and incurable symptoms, causes immense suffering economic burden for patients due to the limited treatment options available. Therefore, it is imperative develop novel promising strategies, as well safe effective drugs, clinical management UC. Macrophages play critical role initial line defense in maintaining intestinal immune homeostasis, their phenotypic transformation significantly influences progression Scientific studies have demonstrated that directing macrophage polarization toward M2 phenotype an strategy prevention Phytochemicals derived from botanical sources garnered interest scientific community owing distinct bioactivity nutritional value, which been shown confer beneficial protective effects against colonic inflammation. In this review, we explicated influence on development UC collated data significant potential natural substances can target elucidate possible mechanism action its treatment. These findings may provide directions references

Language: Английский

Citations

27
Targeting survivin with Tanshinone IIA inhibits tumor growth and overcomes chemoresistance in colorectal cancer DOI Creative Commons
Yaoquan Cao, Haibo Tang, Guohui Wang

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 25, 2023

The inhibitor of apoptosis protein survivin has a critical regulatory role in carcinogenesis and treatment tolerance colorectal cancer (CRC). However, the targeted drugs for are extremely limited. In present research, we discovered that Tanshinone IIA (Tan IIA) played dual inhibiting tumorigenesis reversing 5-Fu via modulating expression phosphorylation CRC cells. Mechanistically, Tan suppressed Akt/WEE1/CDK1 signaling pathway, which led to downregulation Thr34 destruction interaction between USP1 promote ubiquitination degradation. Furthermore, significantly facilitated chemoresistant cells sensitivity. These results revealed possessed strong antitumor activity against could act as an up-and-coming agent treating overcoming chemotherapy resistance.

Language: Английский

Citations

15
Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties DOI Creative Commons
Isabel Vidal, José Antonio Torres‐Vargas, José María Sánchez

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1101 - 1101

Published: May 15, 2023

The role played by a sustained angiogenesis in cancer and other diseases stimulates the interest search for new antiangiogenic drugs. In this manuscript, we provide evidence that 1,8- dihydroxy-9,10-anthraquinone (danthron), isolated from fermentation broth of marine fungus Chromolaenicola sp. (HL-114-33-R04), is inhibitor angiogenesis. results obtained with vivo CAM assay indicate danthron potent compound. vitro studies human umbilical endothelial cells (HUVEC) reveal anthraquinone inhibits certain key functions activated cells, including proliferation, proteolytic invasive capabilities tube formation. breast carcinoma MDA-MB231 fibrosarcoma HT1080 cell lines suggest moderate antitumor antimetastatic activity Antioxidant properties are evidenced observation it reduces intracellular reactive oxygen species production increases amount sulfhydryl groups tumor cells. These support putative as drug potential application treatment angioprevention angiogenesis-dependent diseases.

Language: Английский

Citations

11
Preparation of Self-Assembled, Curcumin-Loaded Nano-Micelles Using Quarternized Chitosan–Vanillin Imine (QCS-Vani Imine) Conjugate and Evaluation of Synergistic Anticancer Effect with Cisplatin DOI Creative Commons
Sasikarn Sripetthong, Sirinporn Nalinbenjapun, Abdul Basit

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 525 - 525

Published: Oct. 18, 2023

Nano-micelles are self-assembling colloidal dispersions applied to enhance the anticancer efficacy of chemotherapeutic agents. In this study, conjugate quarternized chitosan and vanillin imine (QCS-Vani imine) was synthesized using reaction a Schiff base characterized by proton-NMR (1HNMR), UV-Vis spectroscopy, FT-IR. The critical micelle concentration (CMC), particle size, zeta potential resulting product were determined. QCS-Vani used as carrier for development curcumin-loaded nano-micelles, their entrapment efficiency (%EE), drug-loading capacity (%LC) in vitro release investigated HPLC analysis. Moreover, nano-micelles containing curcumin combined with various concentrations cisplatin evaluated possible synergistic effect. activity against lung cancer A549 mouse fibroblast L929 cell lines. percent yield (%) 93.18%. found have spherical shape (by TEM) size < 200 nm DLS) high %EE up 67.61% %LC 6.15 ± 0.41%. loaded lyophilized powder more stable at 4 °C than room temperature during 120 days storage. pH-sensitive properties observed higher pH 5.5 (cancer environment) 7.4 (systemic environment). Curcumin-loaded showed cytotoxicity selectivity toward lines exhibited lower toxicity normal (H9C2) pure curcumin. an enhanced property inducing cycle arrest S-phase cells prominently induced apoptosis compared that co-treatment presented effect, showing 8.66 0.88 μM IC50 value, comparison treatment alone (14.22 1.01 μM). These findings suggest developed nano-micelle is drug delivery system could be promising approach treating combination cisplatin.

Language: Английский

Citations

10
Sodium tanshinone IIA sulfonate alleviates fetal growth restriction by mediating aquaporin‐3 expression in placental trophoblast cells DOI Open Access

Shuangjia Pan,

Anjian Xu,

B. Chen

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 18, 2025

Fetal growth restriction (FGR) is characterized by the inability of fetus to achieve its potential due pathological factors, most commonly impaired placental trophoblast cell function. Currently, effective prevention and treatment methods FGR are limited. We aimed explore pathogenesis provide strategies for mitigating occurrence. The case-control study compared AQP3 expression in cells pregnant women with those normal pregnancies. Then mouse models were induced via cadmium exposure, (JEG-3) similarly treated. assessed effects Sodium tanshinone IIA sulfonate (STS) role PI3K/Akt pathway improving Placental cases exhibited significantly reduced expression. AQP3-knockdown displayed dysfunction. Cadmium exposure mice JEG-3 led decreased dysfunction, both which ameliorated STS. weight increased STS treatment. upregulated improved function cells. Inhibiting diminished STS's beneficial effects. ThereforeSTS may enhance affected through activation pathway, ultimately bolstering alleviating FGR. As above, appears be a therapeutic agent

Language: Английский

Citations

0
Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review DOI Creative Commons
Maya G. Pillai,

A. Helen

Published: June 27, 2024

Traditional medicine systems worldwide utilize natural products (NPs), including plant-derived compounds, minerals, and organisms, harnessing their healing potential. NPs offer a rich source of potential drug candidates, driving innovation in discovery. Recent breakthroughs have reignited interest the therapeutic benefits compounds. Clinical applications NP-based immunotherapies, such as curcumin resveratrol cancer treatment, highlight diverse pharmacological properties. However, despite these advancements, challenges persist clinical implementation NPs. Issues standardization, regulatory approval, supply sustainability remain significant hurdles. Overcoming limitations requires concerted effort to address complexities NP development. Nevertheless, ongoing research efforts interdisciplinary collaboration hold promise for advancing therapeutics, paving way development innovative treatments various diseases. In world precision medicine, new chapter unfolds join journey. The exploration sources bioactive compounds has revealed promising prospects therapeutics medicine. This article explores within context It examines intricate pathways through which derived from nature tailored prospects, emphasizing role interventions. Exploring synergy between at molecular level, this delineates exciting prospect customized treatments, signifying transformative impact on modern medical care. review further highlights tailoring based individual genetic makeup disease characteristics. Additionally, it discusses addressing issues sourcing, scalability, considerations realize full

Language: Английский

Citations

3
Reviewing the Prospective Pharmacological Potential of Isothiocyanates in Fight against Female-Specific Cancers DOI Open Access

Shoaib Shoaib,

Mir Azam Khan, Meshari A. Alsharif

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2390 - 2390

Published: April 20, 2023

Gynecological cancers are the most commonly diagnosed malignancies in females worldwide. Despite advancement of diagnostic tools as well availability various therapeutic interventions, incidence and mortality female-specific is still a life-threatening issue, prevailing one major health problems Lately, alternative medicines have garnered immense attention intervention against types cancers, seemingly because their safety profiles enhanced effectiveness. Isothiocyanates (ITCs), specifically sulforaphane, benzyl isothiocyanate, phenethyl shown an intriguing potential to actively contribute cancer cell growth inhibition, apoptosis induction, epigenetic alterations, modulation autophagy stem cells cancers. Additionally, it has been that ITCs plausibly enhance chemo-sensitization many chemotherapeutic drugs. To this end, evidence efficacy combinatorial regimens with conventional drugs and/or other phytochemicals. Reckoning these, herein, we discuss advances knowledge regarding aspects highlighting molecular intricacies In addition, also argued either solitary treatment or regimen for prevention Hopefully, review will open new horizons consideration interventions would undoubtedly improve prognosis clientele. Considering all reasonable state better understanding these provide facile opportunity treating

Language: Английский

Citations

7
Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways for Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives DOI
Jhimli Banerjee, Sovan Samanta, Rubai Ahmed

et al.

Current Protein and Peptide Science, Journal Year: 2023, Volume and Issue: 24(10), P. 820 - 842

Published: April 19, 2023

Abstract: Nowadays, discovering an effective and safe anticancer medication is one of the major challenges. Premature death due to unidirectional toxicity conventional therapy common in cancer patients with poor health status. Plants have been used as medicine since prehistoric times, extensive research on properties various bioactive phytomolecules ongoing. Pentacyclic triterpenoids are secondary metabolites plants well-known cytotoxic chemopreventive established numerous studies. The lupane, oleanane, ursane groups these well-studied recent decades for their potential antitumor activity. This review delves into molecular machinery governing plant-derived triterpenes' efficacy. highlighted mechanisms antiproliferative activity, induction apoptosis through regulation BCL-2 BH3 family proteins, modulation inflammatory pathway, interference cell invagination inhibition metastasis. Lack solubility mostly biological solvents barrier therapeutic progress triterpenoids. also highlights some probable ways mitigate this issue help nanotechnology modification physical forms.

Language: Английский

Citations

5
Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma DOI
Xiangzhi Meng, Weijian Song, Boxuan Zhou

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2023, Volume and Issue: 149(18), P. 16311 - 16335

Published: Sept. 12, 2023

Language: Английский

Citations

5
Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma DOI Creative Commons
Shuangze Han, Xinfang Yu, Ruirui Wang

et al.

Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(13), P. 2481 - 2490

Published: Jan. 1, 2023

Apoptosis alteration is responsible for tumorigenesis and tumor resistance to therapies. The natural product Tanshinone IIA (Tan IIA) exhibits potent inhibitory effects against various tumors. However, the effect of Tan on apoptosis its underlying mechanism remains elusive in oral squamous cell carcinoma (OSCC). Here, we demonstrated that dose-dependently suppressed viability colony formation CAL27, SCC4, SCC25 cells. Moreover, inhibited Akt activation from inducing Foxo3a dephosphorylation PUMA-mediated apoptosis. PUMA or knockdown compromised OSCC administration CAL27-deprived xenograft growth increased expression vivo. synergistically intensified efficacy CDDP/5-FU-based chemotherapy Overall, our results revealed exerted antitumor via promoting

Language: Английский

Citations

3