Investigating causal relationships of blood and urine biomarkers with urological cancer risks: a mendelian randomization study and colocalization analyses DOI Creative Commons
Jian Li, Bing Yang, Lei Guo

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 16(3), P. 1020 - 1031

Published: Dec. 31, 2024

Background: Establishing the causal links between biomarkers and cancer enhances understanding of risk factors facilitates discovery therapeutic targets.To this end, we used Mendelian randomization (MR) colocalization analysis to explore relationship blood urinary (BUBs) with urological cancers (UCs).Methods: First, a two-sample MR study 33 BUBs 4 UCs, while performed reverse randomization.After Bonferroni correction, for BUB UC significant causality confirmed direct by multivariate adjusting relevant factors.We also applied two-step further possible mediators causality, was BUB, mediators.Sensitivity were assess robustness results.Results: A found that there 8 CA, IGF-1, LPA, TP, CRE, BILD, TBIL NAP potential some UCs (p<0.05), but after correction only IGF-1 had PCa (OR = 1.14, 95% CI: 1.06-1.23;p=0.0006<0.05/33).Moreover, remained (P<0.05) in study.The SHBG be mediator PCa, common variant (nearby gene TNS3) (PPH4=93.21%),which mediating effect SHBG. Conclusion:Strong evidence from our suggests increases decreasing levels, addition have UCs.

Language: Английский

Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer DOI Creative Commons
Nan Zhang, Xinjia Wang, Yu Li

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 17, 2025

Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding in eukaryotes. Studies demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles tumorigenesis, metastasis, drug response cancer by influencing expression altering the processes tumor initiation progression. This review aims summarize recent advances research on circRNA-protein interactions (CPIs) discuss functions mode action CPIs at various stages expression, including transcription, splicing, translation, post-translational modifications context cancer. Additionally, we explore role resistance gain deeper understanding potential applications development new anti-cancer therapeutic approaches.

Language: Английский

Citations

1
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

Citations

4
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer DOI Creative Commons
Xiang Pan, Kaiwen Chen, Wei Gao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications DOI Creative Commons

Xianping Zheng,

Ling Song,

Ce Cao

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 27, 2025

Prostate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs many human diseases. In prostate cancer, can act as oncogenes or tumour suppressor genes and affect cell proliferation, invasion, resistance chemotherapy and, consequently, disease progression. Accordingly, cancer-related are expected serve new targets early clinical diagnosis targeted therapy, but various roles not been fully elucidated. This article reviews pathological circRNA explores its prospects a translational medicine treatment prognostic evaluation.

Language: Английский

Citations

0
Exosomal circRNAs: key modulators in breast cancer progression DOI Creative Commons
Guozhen Liu, Quan Liu,

Lingmei Jia

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Breast cancer (BC) poses significant challenges globally, necessitating a deeper understanding of its complexities. Exosomes are cell-specific secreted extracellular vesicles interest, characterized by lipid bilayer structure. can carry variety bioactive components, including nucleic acids, lipids, amino and small molecules, to mediate intercellular signaling. CircRNAs novel class single-stranded RNA closed-loop mainly exert ceRNA functions intricately modulate gene expression signaling pathways in breast cancer, influencing tumor progression therapeutic responses. The unique packaging circRNAs within exosomes serves as genetic information transmitters, facilitating communication between BC cells microenvironmental cells, thereby regulating critical aspects progression, immune evasion, drug resistance. Besides, exosomal possess the capabilities serving diagnostic biomarkers BC, due their stability, specificity, regulatory roles tumorigenesis metastasis. Therefore, this review aims elucidate mechanisms well potential for diagnosis therapeutics. ongoing investigations will potentially revolutionize treatment paradigms improve patient outcomes BC.

Language: Английский

Citations

0
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway DOI Creative Commons

Fangwen Zou,

Yifang Tang,

Xiaojing Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 24, 2024

Recent evidence has demonstrated that abnormal expression and regulation of circular RNA (circRNAs) are implicated in the development progression various tumors. The aim this study was to investigate effects circ_SMA4 Gastrointestinal Stromal Tumors (GISTs) malignant progression. Human circRNAs microarray analysis conducted identify differentially expressed (DE) GISTs. effect on cell proliferation, invasion, migration, apoptosis assessed both vitro vivo settings. Dual-luciferase reporter assay, RT-qPCR, Western-blot, rescue assay were employed confirm interaction between circ_SMA4/miR-494-3p/ KIT axis. results revealed significantly upregulated GISTs, exhibited high diagnostic efficiency with an AUC 0.9824 (P < 0.01). promoted while inhibiting GISTs cells, vivo. Silencing partially inhibited Additionally, acted as a competing endogenous (ceRNA) by targeting miR-494-3p, identified functional gene for miR-494-3p Furthermore, confirmed axis plays role activating JAK/STAT signaling pathway Therefore, first time, we have emphasized is oncogenic sponging activate KIT/JAK/STAT pathway. These findings underscore may serve novel biomarker therapeutic target

Language: Английский

Citations

2
Biologic activity and treatment resistance to gastrointestinal cancer: the role of circular RNA in autophagy regulation DOI Creative Commons
Bo Zhang, Zhe Li,

Guoliang Ye

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 30, 2024

Circular RNAs (circRNAs) lack the 5'-end methylated guanine cap structure and 3' polyadenylate tail structure, classifying it as a non-coding RNA. With extensive investigation of circRNA, its role in regulating cell death has garnered significant attention recent years, establishing recognized participant cancer's biological processes. Autophagy, an essential pathway programmed (PCD), involves formation autophagosomes using lysosomes to degrade cellular contents under regulation various autophagy-related (ATG) genes. Numerous studies have demonstrated that circRNA can modulate activity cancer cells by influencing autophagy pathway, exhibiting dualistic suppressing or promoting carcinogenesis. In this review, we comprehensively analyze how impacts progression gastrointestinal (GIC). Additionally, discuss drug resistance phenomena associated with GIC. This review offers valuable insights into exploring potential targets for prognosis treatment strategies related

Language: Английский

Citations

1
Investigating causal relationships of blood and urine biomarkers with urological cancer risks: a mendelian randomization study and colocalization analyses DOI Creative Commons
Jian Li, Bing Yang, Lei Guo

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 16(3), P. 1020 - 1031

Published: Dec. 31, 2024

Background: Establishing the causal links between biomarkers and cancer enhances understanding of risk factors facilitates discovery therapeutic targets.To this end, we used Mendelian randomization (MR) colocalization analysis to explore relationship blood urinary (BUBs) with urological cancers (UCs).Methods: First, a two-sample MR study 33 BUBs 4 UCs, while performed reverse randomization.After Bonferroni correction, for BUB UC significant causality confirmed direct by multivariate adjusting relevant factors.We also applied two-step further possible mediators causality, was BUB, mediators.Sensitivity were assess robustness results.Results: A found that there 8 CA, IGF-1, LPA, TP, CRE, BILD, TBIL NAP potential some UCs (p<0.05), but after correction only IGF-1 had PCa (OR = 1.14, 95% CI: 1.06-1.23;p=0.0006<0.05/33).Moreover, remained (P<0.05) in study.The SHBG be mediator PCa, common variant (nearby gene TNS3) (PPH4=93.21%),which mediating effect SHBG. Conclusion:Strong evidence from our suggests increases decreasing levels, addition have UCs.

Language: Английский

Citations

0