Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 9, 2025

Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and crucial determinant progression. Research indicates that various metabolic regulators form network in TME interact with immune cells, coordinating response. dysregulation creates an immunosuppressive TME, impairing antitumor In this review, we discuss how affect cell crosstalk TME. We also summarize recent clinical trials involving challenges metabolism-based therapies translation. word, our review distills key regulatory factors their mechanisms action from complex metabolism, identified as regulators. These provide theoretical basis research direction for development new strategies targets therapy based on reprogramming. Refining Depicting between stromal cells during Emphasizing unresolved translation advantages personalized treatment. Providing support therapies.

Language: Английский

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Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity known used, they often fail to achieve satisfactory long-term patient outcomes survival. Recently, immunotherapy has shown success patients by harnessing important interactions between immune system cancer. However, many these therapies lead frequent side effects when administered systemically, prompting treatment modifications or discontinuation or, severe cases, fatalities. New approaches like intratumoral immunotherapy, characterized reduced effects, cost, systemic toxicity, offer promising prospects for future applications clinical oncology. In context locally metastatic cancer, combining diverse immunotherapeutic other targeting multiple cancer hallmarks appears crucial. Such combination hold promise improving survival promoting a sustained response. This review aims provide overview approaches, specifically focusing on administration drugs cancers. It also explores integration modalities maximize Additionally, summarizes recent advances discusses novel outlining directions field.

Language: Английский

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Molecular principles underlying aggressive cancers

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 16, 2025

Language: Английский

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Oral Cancer Stem Cells: A Comprehensive Review of Key Drivers of Treatment Resistance and Tumor Recurrence

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177222 - 177222

Published: Jan. 1, 2025

Language: Английский

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Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

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Multi Omics Applications in Biological Systems

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5777 - 5793

Published: June 11, 2024

Traditional methodologies often fall short in addressing the complexity of biological systems. In this regard, system biology omics have brought invaluable tools for conducting comprehensive analysis. Current sequencing capabilities revolutionized genetics and genomics studies, as well characterization transcriptional profiling dynamics several species sample types. Biological systems experience complex biochemical processes involving thousands molecules. These occur at different levels that can be studied using mass spectrometry-based (MS-based) analysis, enabling high-throughput proteomics, glycoproteomics, glycomics, metabolomics, lipidomics Here, we present most up-to-date techniques utilized completion Additionally, include some interesting examples applicability multi to a variety

Language: Английский

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Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 22, 2024

Abstract Cancer stem cells (CSCs) represent a small yet pivotal subset of tumor endowed with self-renewal capabilities. These are intricately linked to progression and central drug resistance, metastasis, recurrence. The microenvironment (TME) encompasses the cancer their surrounding milieu, including immune inflammatory cells, cancer-associated fibroblasts, adjacent stromal tissues, vasculature, variety cytokines chemokines. Within TME, such as endothelial adipocytes, fibroblasts release growth factors, cytokines, chemokines, exosomes, which can either sustain or disrupt CSCs, thereby influencing progression. Conversely, CSCs also secrete affecting various components TME. Exosomes, extracellular vesicles (EVs), carry complex cargo nucleic acids, proteins, lipids, playing crucial role in communication between This review primarily focuses on impact exosomes secreted by (CSC-exo) progression, roles maintaining stemness, promoting angiogenesis, facilitating inducing suppression, contributing resistance. Additionally, we discuss how different within TME affect CSCs. Finally, explore potential utilizing mitigate detrimental effects target eliminate them. A thorough understanding exosome-mediated crosstalk could provide valuable insights for developing targeted therapies against

Language: Английский

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Circular RNAs as Key Regulators in Cancer Hallmarks: New Progress and Therapeutic Opportunities

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104612 - 104612

Published: Jan. 1, 2025

Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, tissue-specific expression. These non-coding function through mechanisms such miRNA sponging, interactions with RNA-binding proteins (RBPs), modulating transcription splicing. Advances RNA sequencing bioinformatics tools enabled the identification functional annotation of across different types. Clinically, demonstrate specificity sensitivity samples, offering potential diagnostic prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, delivery systems are under investigation. However, precise remain unclear, more clinical evidence is needed regarding roles hallmarks. Understanding will pave way for novel approaches, potentially improving patient outcomes.

Language: Английский

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An in-depth study of indolone derivatives as potential lung cancer treatment

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

Lung cancer is a type of that begins in the lungs and one leading causes cancer-related deaths worldwide. Herein an attempt to explore relationship between properties indolone derivatives their anticancer activity was investigated, implementing silico approaches. Four with highest potential were selected evaluate pharmacological properties. The ADMET analysis revealed these compounds exhibited favourable drug-like properties, meeting nearly all key criteria required for therapeutic agents. Molecular docking studies most active strong interactions critical amino acid residues PDK1 receptor's binding site, underscoring as effective inhibitors. In addition, 200 ns molecular dynamics (MD) simulations two R S configurations validated stability ligand-receptor complexes, minimal structural deviations observed throughout simulation period. These comprehensive results highlight viable drug candidates provide solid foundation future optimization efforts aimed at developing novel inhibitors therapy.

Language: Английский

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“Cell dedifferentiation” versus “evolutionary reversal” theories of cancer: The direct contest of transcriptomic features

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Cell dedifferentiation is considered an important hallmark of cancer. The atavistic reversal to a unicellular‐like (UC) state less widely accepted concept, so far not included in the conventional hallmarks. activated expression ontogenetically earlier and evolutionary genes cancers supports both theories because ontogenesis partially recapitulates phylogenesis during cell differentiation (the cellular biogenetic law). We directly contested types gene signatures stem vs. differentiated cancer normal cells, using meta‐analysis human single‐cell transcriptomes (totally, 38 pairwise comparisons involving over 18,600 cells). Because compared cells can differ proliferation rate, correction for cycle activity was applied. Taken together as multiple variables analyses, ontogenetic signature excluded UC from predictive variables, usually even forcing it change sign prediction (from plus minus). In contrast, signature. Thus, direct contest decided favor theory placed UC‐like central cancer, which has plausible evolutionarily formed mechanism (UC attractor) generate other These data suggest paradigm shift understanding oncogenesis propose integrative framework research. practical sense, upregulation indicates potential tumorigenicity, be used early diagnostics regenerative medicine. For therapy, these results center networks universal target.

Language: Английский

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