Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111380 - 111380
Published: Sept. 3, 2024
Language: Английский
Current Opinion in Genetics & Development, Journal Year: 2024, Volume and Issue: 87, P. 102209 - 102209
Published: June 1, 2024
Epitranscriptomics, the study of reversible and dynamic chemical marks on RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation. Increasing knowledge about epitranscriptomic landscapes implicated disease pathogenesis proves an invaluable opportunity for identification biomarkers development new potential therapeutic drugs. Hence, recent advances characterization these associated enzymes both health blaze trail toward use epitranscriptomics approaches clinical applications. Here, we review latest studies to provide wide comprehensive perspective emphasize its transformative shaping future care paradigms.
Language: Английский
Citations
4
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(11), P. 101064 - 101064
Published: Aug. 5, 2024
Recently, snoRNAs have transcended the genomic "noise" to emerge as pivotal molecular markers due their essential roles in tumor progression. Substantial evidence indicates a strong association between and critical clinical features such pathology drug resistance. Historically, snoRNA research has concentrated on two classical mechanisms: 2'-O-ribose methylation pseudouridylation. This review specifically summarizes novel regulatory mechanisms functional patterns of tumors, encompassing transcriptional, post-transcriptional, post-translational regulation. We further discuss synergistic effect host genes (SNHGs) More importantly, extensively contribute development cell resistance oncogenes or suppressor genes. Accordingly, we provide comprehensive diagnosis treatment associated with explore significant potential targets.
Language: Английский
Citations
4
Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217269 - 217269
Published: Sept. 1, 2024
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130642 - 130642
Published: March 7, 2024
Language: Английский
Citations
1
Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: June 11, 2024
Abstract Background Vasculogenic mimicry (VM) is an enigmatic physiological feature that influences blood supply within glioblastoma (GBM) tumors for their sustained growth. Previous studies identify NFATC3, FOSL1 and HNRNPA2B1 as significant mediators of VEGFR2, a key player in vasculogenesis, molecular relationships may be crucial VM GBM. Aims The aim this study was to understand how collectively influence Methods We have investigated the underlying gene regulatory mechanisms GBM cell lines U251 U373 vitro vivo . In cell-based assays were performed explore role proliferation, migration, context RNA interference (RNAi)-mediated knockdown alongside corresponding controls. Western blotting qRT-PCR used examine VEGFR2 expression levels. CO-IP employed detect protein–protein interactions, ChIP DNA–protein complexes, RIP RNA–protein complexes. Histochemical staining tube formation vivo. Results Focusing on HNRNPA2B1, we found each significantly upregulated positively correlated with VM-like cellular behaviors lines. Knockdown or resulted decreased levels growth factor drives VM, well inhibition migration extracorporeal activity. Chromatin immunoprecipitation (ChIP) luciferase reporter revealed NFATC3 binds promoter region enhance expression. Notably, interacts co-factor potentiate DNA-binding capacity resulting enhanced behaviors. Also, level protein cells through binding mRNA. Furthermore, RNAi-mediated silencing reduced tumor Conclusion Taken together, our findings important mediator its epistatic interactions Graphical 1. which leads increase 2. further facilitate VM. 3. enhances mRNA stability
Language: Английский
Citations
1
Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111380 - 111380
Published: Sept. 3, 2024
Language: Английский
Citations
0