Behavioral and Brain Functions,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: May 3, 2024
In
the
present
study,
we
investigated
effect
of
high-intensity
interval
training
(HIIT)
on
cognitive
behaviors
in
female
rats
with
a
high-fat
diet
+
streptozotocin
(STZ)-induced
type
2
diabetes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5716 - 5716
Published: May 24, 2024
Alzheimer’s
disease
(AD)
is
characterized
by
the
deposition
in
brain
of
senile
plaques
composed
amyloid-β
peptides
(Aβs)
that
increase
inflammation.
An
endogenous
peptide
derived
from
insulin-like
growth
factor
(IGF)-I,
glycine-proline-glutamate
(GPE),
has
IGF-I-sensitizing
and
neuroprotective
actions.
Here,
we
examined
effects
GPE
on
Aβ
levels
hippocampal
inflammation
generated
intracerebroventricular
infusion
Aβ25-35
for
2
weeks
(300
pmol/day)
ovariectomized
rats
signaling-related
pathways
Aβ-degrading
enzymes
associated
with
these
GPE-related
effects.
prevented
Aβ-induced
phosphorylation
p38
mitogen-activated
protein
kinase
reduction
activation
signal
transducer
activator
transcription
3,
insulin
receptor
substrate-1,
Akt,
as
well
interleukin
(IL)-2
IL-13
hippocampus.
The
functionality
somatostatin,
measured
percentage
inhibition
adenylate
cyclase
activity
insulin-degrading
enzyme,
was
also
preserved
co-treatment.
These
findings
indicate
co-administration
may
protect
insult
changing
cytokine
content
somatostatin
through
regulation
leptin-
IGF-I-signaling
could
influence
modulation
and/or
proteases.
European Journal of Sport Science,
Journal Year:
2024,
Volume and Issue:
24(7), P. 899 - 906
Published: June 14, 2024
This
study
was
conducted
to
investigate
the
effects
of
12
weeks
aerobic
exercise
(AT)
and
saffron
supplementation
on
hemostasis,
inflammatory
markers,
insulin
resistance
in
obese
women
diagnosed
with
type
2
diabetes
(T2D).
A
total
44
T2D
(mean
age:
54.12
±
5.63
years,
mean
BMI:
31.15
1.50
kg/m
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(15), P. e34917 - e34917
Published: July 20, 2024
BackgroundThis
study
aimed
to
investigate
the
effect
of
eight
weeks
high-intensity
interval
training
(HIIT)
on
muscle
metabolism
in
rats
with
type
2
diabetes
(T2D)
using
metabolomics
approaches.Methods20
male
Wistar
at
age
8
weeks-were
assigned
four
groups
five,
each
group
randomly:
control
(CTL),
(DB),
HIIT
(EX),
and
+
(DBX).
T2D
was
induced
by
two
months
a
high-fat
diet
plus
single
dose
streptozotocin
(35
mg/kg).
Rats
EX
DBX
performed
(running
80–100
%
Vmax,
4–10
intervals).
NMR
spectroscopy
used
determine
changes
metabolome
profile
after
training.ResultsChanges
metabolite
abundance
following
exercise
revealed
distinct
clustering
multivariate
analysis.
The
essential
between
DB
CTL
were
arginine
metabolism,
purine
phosphate
pathway,
amino
sugar
glutathione
aminoacyl-tRNA
biosynthesis.
However,
Arginine
biosynthesis,
pyrimidine
alanine,
aspartate,
glutamate
altered
groups.ConclusionThese
results
suggest
that
could
reverse
metabolic
rat
muscles,
contributing
reduced
FBG
HOMA-IR
levels.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2783 - 2783
Published: Dec. 6, 2024
Type
2
diabetes
mellitus
(T2DM),
accounting
for
the
majority
of
prevalence,
is
associated
with
an
increased
risk
cognition
decline
and
deterioration
function
in
diabetic
patients.
The
sodium–glucose
cotransporter
(SGLT2),
located
renal
proximal
tubule,
plays
a
role
urine
glucose
reabsorption.
SGLT2
inhibitors
(SGLT2i),
have
shown
potential
benefits
beyond
cardiac
improvement
preventing
treating
cognitive
impairment
(CI),
including
mild
impairment,
Alzheimer’s
disease
vascular
dementia
T2DM
Studies
suggest
that
SGLT2i
may
ameliorate
CI
through
metabolism
pathways,
inflammation,
oxidative
stress,
neurotrophic
factors
AChE
inhibition.
Clinical
trials
meta-analyses
reported
significant
insignificant
results.
Given
their
effects,
offer
unique
protection
against
CI.
This
review
compiles
mechanisms
clinical
evidence,
emphasizing
need
future
analysis,
evaluation,
to
verify
recommend
optimal
selection
dosage
specific
