Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 18, 2024
Language: Английский
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Language: Английский
Citations
1
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 10, 2025
Language: Английский
Citations
1
Life Sciences, Journal Year: 2024, Volume and Issue: 356, P. 123019 - 123019
Published: Aug. 28, 2024
An increase in life expectancy comes with a higher risk for age-related neurological and cognitive dysfunctions. Given the psycho-socioeconomic burden due to unhealthy aging coming decades, United Nations has declared 2021-2030 as decade of healthy aging. In this line, multipotent mesenchymal stromal cell-based therapeutics received special interest from research community. Based on decades cell therapy, consensus emerged that therapeutic effects therapy are paracrine mechanisms rather than replacement. Exosomes, constituent secretome, nano-sized vesicles have been focus intense recent years possible agent or cargo deliver drugs into central nervous system induce neurogenesis, reduce neuroinflammation, confer neuroregeneration/neuroprotection, improve motor functions. review, we discussed neuroprotective properties exosomes derived adult stem cells, role exosomal miRNAs. We also reviewed various strategies exosome production their content better effects. Further, utilization ectomesenchymal cells like dental pulp treating neurodegenerative diseases.
Language: Английский
Citations
6
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)
Published: May 21, 2024
Mesenchymal stem cell-derived exosomes (MSC-Exos) are emerging as remarkable agents in the field of immunomodulation with vast potential for diagnosing and treating various diseases, including cancer autoimmune disorders. These tiny vesicles laden a diverse cargo encompassing proteins, nucleic acids, lipids, bioactive molecules, offering wealth biomarkers therapeutic options. MSC-Exos exhibit their immunomodulatory prowess by skillfully regulating pattern-recognition receptors (PRRs). They conduct symphony immunological responses, modulating B-cell activities, polarizing macrophages toward anti-inflammatory phenotypes, fine-tuning T-cell activity. interactions have profound implications precision medicine, immunotherapy, disease management, biomarker discovery, regulatory approvals. promises to usher new era tailored therapies, personalized diagnostics, more effective treatments medical conditions. As research advances, transformative healthcare becomes increasingly evident.
Language: Английский
Citations
5
The Ocular Surface, Journal Year: 2024, Volume and Issue: 34, P. 459 - 476
Published: Oct. 1, 2024
Language: Английский
Citations
4
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 21, 2025
Abstract Dry eye disease (DED) is a prevalent inflammatory condition significantly impacting quality of life, yet lacks effective pharmacological therapies. Herein, we proposed novel approach to modulate the inflammation through metabolic remodeling, thus promoting dry recovery. Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded best therapeutic outcome against eye, surpassing monotherapy outcomes. In situ metabolomics matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased glutamine levels in cornea following MSC + Tβ4 combined therapy. Inhibition reversed anti-inflammatory, anti-apoptotic, homeostasis-preserving effects observed therapy, highlighting critical role Clinical cases rodent model showed elevated expression glutaminase (GLS1), an upstream enzyme metabolism, injury. Mechanistic studies indicated overexpression inhibition GLS1 counteracted enhanced, respectively, anti-inflammatory underscoring GLS1’s pivotal regulating metabolism. Furthermore, single-cell sequencing distinct subset pro-inflammatory pro-fibrotic corneal epithelial model, while treatment downregulated those subclusters, thereby reducing their cytokine secretion. summary, effectively ameliorated occurrence apoptosis by downregulating subclusters related IκBα/NF-κB signaling. The present suggests metabolism plays critical, previously unrecognized DED proposes attractive strategy enhance inhibiting alleviating inflammation-driven progression.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Language: Английский
Citations
0
Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)
Published: March 12, 2025
Neuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunction, arrest oligodendrocyte maturation, and long-term neurological damage. As potential therapeutic strategy, mesenchymal stem cells (MSCs) exhibit significant immunomodulatory regenerative potential. Recent studies suggest that primary mechanism MSC action their paracrine effects, particularly mediated by extracellular vesicles, with MSC-derived exosomes (MSC-Exos) being mediators. MSC-Exos, enriched lipids, proteins, nucleic acids, regulate neuroinflammation modulating activity influencing signaling pathways associated inflammation repair. Preclinical evidence has indicated MSC-Exos can suppress activation microglia astrocytes, promote enhance myelination, highlighting as cell-free treatment for PWMI. However, there are paucity comprehensive reviews on how PWMI through specific pathways. This review aims summarize which modulate discuss challenges clinical application MSC-Exos-based therapies.
Language: Английский
Citations
0
Extracellular Vesicle, Journal Year: 2025, Volume and Issue: 5, P. 100071 - 100071
Published: March 22, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 529 - 529
Published: April 2, 2025
Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to long-term functional impairment. Despite advances in therapies, current repair strategies offer unsatisfactory outcomes. Exosomes derived from induced pluripotent stem cells (iPSC-Exos) have emerged as promising therapeutic approach regenerative medicine. This study assesses the efficacy and safety of iPSC-Exos rat model sciatic crush injury. Briefly, iPSCs were generated peripheral blood mononuclear (PBMCs) healthy donors using Sendai virus vectors validated for pluripotency. characterized injected at site. Functional recovery was assessed through gait analysis, grip strength, pain response. Histological molecular analyses used examine axonal regeneration, myelination, Schwann cell (SC) activation, angiogenesis, changes gene expression. efficiently internalized by SC, promoting their proliferation. No adverse effects observed between groups on body weight, organ histology, or hematological parameters. injection significantly enhanced muscle preservation, vascularization, with RNA sequencing revealing activation PI3K-AKT focal adhesion pathways. These findings support safe effective non-cell-based therapy PNIs, highlighting potential applications
Language: Английский
Citations
0