Fibrinogen-to-albumin ratios are related to mortality in patients with secondary malignant neoplasm of bone and bone marrow DOI Creative Commons

Jinsha Zhong

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18797 - e18797

Published: July 28, 2023

Systemic inflammation has long been considered to be one of the mechanisms in development and progression secondary malignant neoplasm bone marrow (BM). Fibrinogen-to-albumin ratio (FAR) demonstrated vital poor prognosis lots disease such as tumor coronary heart disease. This study aimed determine whether FAR could used an independent risk prognostic factor patients with BM.Firstly, baseline data BM, who met our inclusion/exclusion criteria, were extracted analyzed from MIMIC-III database. The association between endpoints was using a Cox proportional hazards regression model propensity score matched analysis.The univariate analysis revealed that for 30-day mortality, HR (95% CI) ≥99.5group 1.47 (1.15,1.91). After adjusting various factors, ≥99.5 found significant death BM (HR = 1.11, 95% CI: 1.01-1.42). Similarly, one-year group 1.51 (1.11, 2.06).It provides information mortality among neoplasms marrow.

Language: Английский

Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review DOI Open Access
Giorgia Natalia Iaconisi, Paola Lunetti,

Nunzia Gallo

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10296 - 10296

Published: June 18, 2023

Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially body fluids and extracellular matrix of tissues. It plays crucial role not only maintaining tissue hydration but also cellular processes such as proliferation, differentiation, inflammatory response. HA has demonstrated its efficacy powerful bioactive molecule for skin antiaging atherosclerosis, cancer, other pathological conditions. Due to biocompatibility, biodegradability, non-toxicity, non-immunogenicity, several HA-based biomedical products have been developed. There an increasing focus on optimizing production achieve high-quality, efficient, cost-effective products. This review discusses HA’s structure, properties, through microbial fermentation. Furthermore, it highlights applications emerging sectors biomedicine.

Language: Английский

Citations

86
Targeted blood-brain barrier penetration and precise imaging of infiltrative glioblastoma margins using hybrid cell membrane-coated ICG liposomes DOI Creative Commons

Ping Liu,

Siyi Lan,

Duyang Gao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 5, 2024

Language: Английский

Citations

8
Cancer on motors: How kinesins drive prostate cancer progression? DOI
Jiaming Wang,

Feng-Hao Zhang,

Zixiang Liu

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 224, P. 116229 - 116229

Published: April 21, 2024

Language: Английский

Citations

4
Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment DOI Creative Commons
Jiang Hua

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 219 - 237

Published: Feb. 1, 2025

Abstract: Prostate cancer is prevalent among men aged 65 and older. Bone metastasis occurs in up to 90% of advanced prostate patients, metastatic generally considered a non-curative condition which can impact quality life. The tumor microenvironment, comprising diverse cellular non-cellular elements, interacts with cells affect growth bone metastasis. Within the different cell types, including osteoblasts, osteoclasts, adipocytes, endothelial cells, hematopoietic stem immune engage cells. Some alter behavior, while others are impacted or overpowered by leading phases movement, dormancy, latency, resistance treatment, advancement visible This review summarizes recent research on microenvironment metastasis, exploring underlying mechanisms potential value targeting these environments for treatment. Keywords: cancer, epithelial-mesenchymal transition, dormancy

Language: Английский

Citations

0
Cancer stem cell analysis and targeting DOI

Mishal Safdar,

Z. M. Amin,

Muneeb Ullah

et al.

Methods in cell biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhanced anti-cancer effects of magnetic targeted pH-sensitive curcumin delivery system based on heterogeneous magnetic α-Fe2O3/Fe3O4 nanoparticles on gastric cancer SGC-7901 cells DOI Creative Commons

Mingyi Ma,

Zhixiang Lv, You Li

et al.

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(12), P. 105352 - 105352

Published: Oct. 12, 2023

Problem: Unhealthy dietary habits and inadequate existing treatment technologies have led to high morbidity mortality rates in patients with gastric cancer, the research shows that curcumin has excellent antitumor properties, however, non-water-soluble characteristic of limits its applications. To break limitation, targeted drug carriers become urgent need treat cancer. Method: The heterogeneous magnetic α-Fe2O3/Fe3O4 nanoparticles were obtained by rapid combustion method citric acid (CA) ferric nitrate as raw materials anhydrous ethanol solvent fuel, then modified chitosan (CTS), loaded (Cur) form α-Fe2O3/Fe3O4-CA-CTS-Cur nanosystem. Results: particle sizes nanosystem 24.9 nm 35.6 nm, respectively, their respective saturation magnetization 70.9 emu/g 30.3 emu/g. had good stability, release rate, enhanced apoptosis cancer cells (SGC-7901) through caspase pathway ferroptosis cells. Conclusions: delivery was successfully constructed, revealed significant inhibitory killing effects on SGC-7901 cells, low toxic side normal

Language: Английский

Citations

5
New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities DOI Creative Commons

Beatrice Cesana,

Claude Cochet, Odile Filhol

et al.

International Journal of Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Abstract Approximately one‐third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective seminal studies on metastasis RCC describing the main molecular modulators and growth factor signaling pathways most important for RCC‐stimulated osteoclast‐mediated destruction. We next focus newer developments revealing with in‐depth details, bidirectional interplay between cancer cells immune stromal microenvironment that can through epigenetic reprogramming, profoundly affect behaviors transformed cells. Understanding their mechanistic interactions is paramount importance advancing both fundamental translational research. These new investigations into landscape RCC‐bone offer novel insights identify potential avenues future therapeutic interventions.

Language: Английский

Citations

1
Bone Endosteal Mimics Regulates Breast Cancer Development and Phenotype DOI
Noa Ben-Ghedalia-Peled, Dane K. Hoffman,

Livnat Barsky

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2338 - 2347

Published: March 19, 2024

Bone is a frequent site for metastatic development in various cancer types, including breast cancer, with grim prognosis due to the distinct bone environment. Despite considerable advances, our understanding of underlying processes leading metastasis progression remains elusive. Here, we applied bioactive three-dimensional (3D) model capable mimicking endosteal microenvironment. MDA-MB-231 and MCF7 cells were cultured on scaffolds, their behaviors effects biomaterial examined over time. We demonstrated that close interactions between affect proliferation rates expression c-Myc, cyclin D, KI67, cell cycle arrest. Moreover, invasion assays revealed increased invasiveness within this Our findings suggest dual role signals, influencing fate potentially acting as double-edged sword, shuttling arrest more active, aggressive states.

Language: Английский

Citations

0
CD44 and RHAMM Are Microenvironmental Sensors with Dual Metastasis Promoter and Suppressor Functions DOI Creative Commons

Cornelia Tölg,

Kathleen A. Hill, Eva A. Turley

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: 8(6)

Published: April 18, 2024

Abstract The progression of primary tumors to metastases remains a significant roadblock the treatment most cancers. Emerging evidence has identified genes that specifically affect metastasis and are potential therapeutic targets for managing tumor progression. However, these can have dual promoter suppressor functions contextual in manifestation, complicate their development as targeted therapies. CD44 RHAMM/HMMR examples multifunctional proteins either promote or suppress metastases, demonstrated experimental models. These two be viewed microenvironmental sensors this minireview addresses known mechanistic underpinnings may determine versus functions. Leveraging knowledge CD44, RHAMM, other is predicted improve precision targeting achieve more effective management metastasis.

Language: Английский

Citations

0
Fibrinogen-to-albumin ratios are related to mortality in patients with secondary malignant neoplasm of bone and bone marrow DOI Creative Commons

Jinsha Zhong

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18797 - e18797

Published: July 28, 2023

Systemic inflammation has long been considered to be one of the mechanisms in development and progression secondary malignant neoplasm bone marrow (BM). Fibrinogen-to-albumin ratio (FAR) demonstrated vital poor prognosis lots disease such as tumor coronary heart disease. This study aimed determine whether FAR could used an independent risk prognostic factor patients with BM.Firstly, baseline data BM, who met our inclusion/exclusion criteria, were extracted analyzed from MIMIC-III database. The association between endpoints was using a Cox proportional hazards regression model propensity score matched analysis.The univariate analysis revealed that for 30-day mortality, HR (95% CI) ≥99.5group 1.47 (1.15,1.91). After adjusting various factors, ≥99.5 found significant death BM (HR = 1.11, 95% CI: 1.01-1.42). Similarly, one-year group 1.51 (1.11, 2.06).It provides information mortality among neoplasms marrow.

Language: Английский

Citations

1