Energetic Aspects and Molecular Mechanism of 3-Nitro-substituted 2-Isoxazolines Formation via Nitrile N-Oxide [3+2] Cycloaddition: An MEDT Computational Study

Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3042 - 3042

Published: June 26, 2024

Regioselectivity and the molecular mechanism of [3+2] cycloaddition reaction between nitro-substituted formonitrile N-oxide

Language: Английский

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Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl N,N-diacyl-β-amino esters

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 212 - 219

Published: Feb. 2, 2024

An efficient multicomponent reaction of newly designed β-trifluoromethyl β-diazo esters, acetonitrile, and carboxylic acids via an interrupted esterification process under copper-catalyzed conditions has been developed, which affords various unsymmetrical N , -diacyl-β-amino esters in good to excellent yields. The features mild conditions, a wide scope β-amino acids, also applicability large-scale synthesis, thus providing way for the synthesis β-diacylamino esters. Furthermore, this represents first example Mumm rearrangement

Language: Английский

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Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, material sciences. Although fluorine-nitrogen chemistry has long rich history, this field received increasing interest made remarkable progress over the past two decades, driven by recent advancements transition metal organocatalysis photochemistry. This review, emphasizing contributions from 2015 to 2023, aims update state of art synthesis applications nitrogen-based organofluorine functional molecules chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according type groups attached nitrogen, including N-F, N-RF, N-SRF, N-ORF. review also covers nitrogen-linked building blocks, catalysts, pharmaceuticals, agrochemicals, underlining these components' broad applicability growing importance modern

Language: Английский

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Iron-catalyzed sulfur alkylation of sulfenamides with in situ-generated 2,2,2-trifluorodiazoethane

Journal of Fluorine Chemistry, Journal Year: 2023, Volume and Issue: 273, P. 110219 - 110219

Published: Nov. 24, 2023

Language: Английский

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