Environmental Science and Pollution Research, Journal Year: 2019, Volume and Issue: 26(17), P. 17834 - 17844
Published: April 29, 2019
Language: Английский
European Journal of Epidemiology, Journal Year: 2020, Volume and Issue: 35(5), P. 483 - 517
Published: May 1, 2020
The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being expanded by persons 40 over. findings have been presented 1700 research articles reports. This article provides update rationale design study. It also presents a summary major from preceding 3 outlines developments coming period.
Language: Английский
Citations
397
Endocrine Practice, Journal Year: 2022, Volume and Issue: 28(10), P. 923 - 1049
Published: Aug. 11, 2022
Language: Английский
Citations
327
Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(16)
Published: June 13, 2021
Abstract Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the body, it incorporated into selenocysteine, amino acid used synthesize selenoproteins, which have active center usually dependent on presence of Se. Although Se shows beneficial properties health, has also a narrow therapeutic window, and therefore excessive intake inorganic organic Se‐based compounds often leads toxicity. Nanoparticles based (SeNPs) are less toxic than They both biocompatible capable effectively delivering combinations payloads specific cells following their functionalization with targeting ligands. Herein, main origin intake, its role primary biomedical applications revised. Particular focus will given targets explored for SeNPs cancer therapies, discussing different methodologies improve stability, while enabling extensive delivery drug‐loaded SeNP tumor sites, thus avoiding off‐target effects.
Language: Английский
Citations
294
Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 251 - 251
Published: Jan. 27, 2022
Selenium is an essential microelement required for a number of biological functions. Selenium-and more specifically the amino acid selenocysteine-is present in at least 25 human selenoproteins involved wide variety functions, ranging from regulation reactive oxygen species (ROS) concentration to biosynthesis hormones. These processes also play central role preventing and modulating clinical outcome several diseases, including cancer, diabetes, Alzheimer's disease, mental disorders, cardiovascular fertility impairments, inflammation, infections (including SARS-CoV-2). Over past years, studies focusing on relationship between selenium such pathologies have been reported. Generally, adequate nutritional state-and some cases supplementation-have related improved prognostic reduced risk developing diseases. On other hand, supra-nutritional levels might adverse effects. The results recent these topics are summarized discussed this review, with particular emphasis advances achieved last decade.
Language: Английский
Citations
235
Current Environmental Health Reports, Journal Year: 2018, Volume and Issue: 5(4), P. 464 - 485
Published: Oct. 2, 2018
Language: Английский
Citations
221
Redox Biology, Journal Year: 2022, Volume and Issue: 50, P. 102236 - 102236
Published: Jan. 24, 2022
This review addresses the role of essential trace element, selenium, in type-2 diabetes mellitus (T2DM) and its metabolic co-morbidities, i.e., syndrome, obesity non-alcoholic fatty liver disease. We refer to dietary requirements selenium key physiological roles selenoproteins. explore dysregulated fuel metabolism T2DM emphasizing relevance inflammation oxidative stress. describe epidemiology observational experimental studies related conditions, explaining that interaction between status glucose control is not limited hyperglycemia but extends hypoglycemia. propose association high plasma/serum T2DM/fasting plasma observed many cross-sectional may rely on upregulation hepatic selenoprotein-P biosynthesis conditions insulin resistance. While animal have revealed potential molecular mechanisms underlying adverse effects severe selenium/selenoprotein excess deficiency pathogenesis resistance β-cell dysfunction, their translational significance rather limited. Importantly, supplementation does appear be a major causal factor for development humans though we cannot currently exclude small contribution top other risk factors, particular if it ingested at (supranutritional) doses. Elevated biomarkers are often measured patients more likely consequence, than cause, diabetes.
Language: Английский
Citations
161
International Journal of Environmental Research and Public Health, Journal Year: 2019, Volume and Issue: 16(7), P. 1185 - 1185
Published: April 2, 2019
Environmental factors are recognized as risk of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout medical and some organic inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such organochlorines pesticides, able disrupt function. Polychlorinated biphenyls metabolites polybrominated diethyl ethers bind thyroid, transport proteins, replace thyroxin, function phthalates bisphenolates do, highly mimicking hormones. A better knowledge environmental risks represents very important tool prevention through true management. This approach is because the epigenetic origin’s theory cancer. Therefore, aim this review was study association between agents promotion.
Language: Английский
Citations
156
Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8
Published: June 4, 2021
This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well relationship with diseases gut microbiota specifically on symbiotic between microflora status. Selenium is essential for maintenance immune system, conversion thyroid hormones, protection against harmful action heavy metals xenobiotics reduction risk chronic diseases. able to balance microbial flora avoiding health damage associated dysbiosis. Experimental studies have shown that inorganic organic selenocompounds are metabolized selenomethionine incorporated by bacteria from microflora, therefore highlighting their role improving bioavailability selenocompounds. Dietary can affect colonization, which turn influences host's status expression selenoproteoma. deficiency may result a phenotype more susceptible cancer, dysfunctions, inflammatory bowel disease, cardiovascular disorders. Although host benefit each other relationship, they become competitors if supply micronutrients limited. Intestinal remove resulting two three times lower levels selenoproteins under selenium-limiting conditions. There still gaps whether these consequences unfavorable humans animals or daily intake also adapted meet needs bacteria.
Language: Английский
Citations
154
Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 799 - 799
Published: May 8, 2023
Selenium is a trace mineral that essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in body form of selenoproteins, which are best known their redox activity anti-inflammatory properties. stimulates activation immune cells important system. also maintenance brain function. supplements can regulate lipid metabolism, cell apoptosis, autophagy, have displayed significant alleviating effects most cardiovascular diseases. However, effect increased intake on risk cancer remains unclear. Elevated serum levels associated with an type 2 diabetes, this relationship complex nonlinear. supplementation seems beneficial to some extent; however, existing studies not fully explained influence Further, more intervention trials needed verify or harmful
Language: Английский
Citations
152
Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 188, P. 146 - 161
Published: June 10, 2022
Language: Английский
Citations
150