Injectable thermosensitive selenium-containing hydrogel as mesenchymal stem cell carrier to improve treatment efficiency in limb ischemia DOI Creative Commons
Xuan Tian, Xin Yan, Nan Zang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100967 - 100967

Published: Jan. 21, 2024

Limb ischemia is a refractory disease characterized by persistent inflammation, insufficient angiogenesis, and tissue necrosis. Although mesenchymal stem cells (MSCs) have shown potential for treating limb ischemia, their therapeutic effects are limited low engraftment rates. Therefore, developing an optimal MSC delivery system that enhances cell viability imperative. Selenium, known its cytoprotective properties in various types, offers strategy to enhance effect of MSCs. In this study, we evaluated the selenium on MSCs, developed injectable thermosensitive selenium-containing hydrogel based PLGA-PEG-PLGA triblock copolymer, as carrier improve after engraftment. The biocompatibility, biodegradability, capabilities hydrogels were assessed. Furthermore, MSCs encapsulated within was using cellular animal experiments. Selenium protects from oxidative damage upregulating GPX4 through transcriptional mechanism. exhibited favorable antioxidant properties. It can be easily injected into target area liquid form at room temperature undergoes gelation body temperature, thereby preventing diffusion promoting cytoprotection effectively inhibited macrophage M1 polarization while M2 polarization, thus accelerating angiogenesis restoring blood perfusion ischemic limbs. This study demonstrated promising method delivery. By addressing challenge retention rate, which major obstacle application, improves ischemia.

Language: Английский

Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2600 - 2600

Published: Feb. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Language: Английский

Citations

38
Unveiling biological activities of biosynthesized starch/silver-selenium nanocomposite using Cladosporium cladosporioides CBS 174.62 DOI Creative Commons
Fathy M. Elkady, Amr H. Hashem, Salem S. Salem

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 8, 2024

Abstract Background and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. Methodology St/Ag-Se NC was using Cladosporium cladosporioides CBS 174.62 ( C. ) strain. shape average particle size investigated scanning electron microscope (SEM) high-resolution transmission (HR-TEM), respectively. On other hand, on two cancer cell lines red blood (RBCs) evaluated its hydrogen peroxide (H 2 O scavenging Moreover, effects microbial species in both planktonic biofilm growth forms examined. Results successfully oval spherical mean diameter 67.87 nm as confirmed by HR-TEM analysis. showed promising anticancer activity toward human colorectal carcinoma (HCT-116) breast (MCF-7) where IC 50 21.37 19.98 µg/ml, Similarly, little RBCs observed low concentration. As well, highest H (42.84%) recorded at concentration mg/ml. Additionally, Staphylococcus epidermidis S. ATCC 12,228 Candida albicans 10,231 highly affected bacterial fungal strains minimum inhibitory concentrations (MICs) 18.75 noticeable dependent. A high suppression percentage, 87.5% 68.05%, aureus when exposed 1 mg/ml 0.5 mg/ml, Conclusion excellent antioxidant activity, haemocompatibility, anti-proliferative concentrations. Also, it exhibited antibiofilm activities.

Language: Английский

Citations

17
Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches DOI
Anupam Awasthi,

Kousik Maparu,

Shamsher Singh

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

4
Selenium Mitigates Caerulein and LPS-induced Severe Acute Pancreatitis by Inhibiting MAPK, NF-κB, and STAT3 Signaling via the Nrf2/HO-1 Pathway DOI

K Swetha,

Mylanayakanahosahalli Chandrashekar Indumathi,

R Sanchit Kishan

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

2
The mechanism of selenium regulating the permeability of vascular endothelial cells through selenoprotein O DOI Creative Commons
Jiawei Wu,

Yanhe Zhang,

Tianjing Liu

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103063 - 103063

Published: Feb. 2, 2024

Vascular diseases, a leading cause of death in human, are strongly associated with pathological damage to blood vessels. The selenoprotein (Sel) have been reported play important roles vascular disease. However, the role SelO disease has not conclusively investigated. present experiment was investigate regulatory mechanism effect on permeability endothelial. H.E staining, FITC-Dextran Dil-AC-LDL staining and FITC-WGA showed that structure damaged, intercellular junctions were disrupted selenium (Se)-deficient. Immunohistochemistry, qPCR Western blot revealed decreased expression adhesion plaque proteins vinculin, talin paxillin, connectivity effector molecules connexin, claudin-1 E-cadherin increased JAM-A N-cadherin, as well ZO-1 signaling pathways ZO-1, Rock, rhoGEF, cingulin MLC-2. In screening 24 Sel mice, most pronounced changes tissues, possible association between junction effectors determined using IBM SPSS Statistics 25. Silencing SelO, endothelial adverse effects present. relationship determined. results Se deficiency lead tissue by decreasing expression, suggesting for regulating permeability.

Language: Английский

Citations

15
The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks DOI Open Access
Qing Meng, Chun-Hsien Su

Published: April 11, 2024

This general review assesses the impact of physical exercise on oxidative and nitrosative stress counteractive role antioxidants, drawing from a systematic literature search up to March 2024 in databases like PubMed Web Science. The highlights studies effect production reactive oxygen species (ROS) nitrogen (RNS) antioxidant responses both human animal models based rigorous inclusion exclusion criteria. Due variety types participants' characteristics, narrative synthesis approach was adopted. findings indicate that moderate boosts defenses, known as hormesis, whereas excessive activity may increase damage. also explores complex effects supplementation, revealing while natural dietary antioxidants support health, high-dose supplements could potentially hinder positive adaptations exercise. Recommendations for athletes active population highlight importance balancing intake optimize health benefits. concludes with call more detailed research tailored nutrition plans dissect these intricate relationships further.

Language: Английский

Citations

15
The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks DOI Creative Commons
Qing Meng, Chun-Hsien Su

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 573 - 573

Published: May 7, 2024

This review comprehensively evaluates the effects of physical exercise on oxidative and nitrosative stress, mainly focusing role antioxidants. Using a narrative synthesis approach, data from empirical studies, reviews, systematic meta-analyses published between 2004 2024 were collated databases like PubMed, EBSCO (EDS), Google Scholar, culminating in inclusion 41 studies. The quality these studies was rigorously assessed to ensure clarity objectives, coherence arguments, comprehensive literature coverage, depth critical analysis. Findings revealed that moderate enhances antioxidant defenses through hormesis, while excessive may exacerbate stress. also highlights natural dietary antioxidants are beneficial, high-dose supplements could impede positive adaptations exercise. In conclusion, calls for more focused research tailored nutrition plans further understand complex interactions optimize health outcomes athletes general population.

Language: Английский

Citations

15
Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms DOI Creative Commons
Egor A. Turovsky,

Alexey S. Baryshev,

Egor Y. Plotnikov

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(2), P. 160 - 160

Published: Jan. 11, 2024

Strokes rank as the second most common cause of mortality and disability in human population across world. Currently, available methods treating or preventing strokes have significant limitations, primarily need to use high doses drugs due presence blood-brain barrier. In last decade, increasing attention has been paid capabilities nanotechnology. However, vast majority research this area is focused on mechanisms anticancer antiviral effects nanoparticles. our opinion, not enough neuroprotective nanomaterials. review, we attempted summarize key molecular brain cell damage during ischemia. We discussed current literature regarding various nanomaterials for treatment strokes. examined features all known nanomaterials, possibility which are currently being studied regard, positive negative properties identified. Particular review was nanoselenium since selenium a vital microelement part very important little-studied proteins, e.g., selenoproteins selenium-containing proteins. An analysis modern studies cytoprotective made it possible establish acute chronic protective aimed combine information action nanoparticles neurodegenerative processes, especially cerebral

Language: Английский

Citations

11
Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases DOI Creative Commons
Klaudia Leszto, Laura Biskup,

Klaudia Korona

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 688 - 688

Published: June 3, 2024

Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending underlying mechanisms developing strategies for prevention treatment. Selenium, crucial participant in redox reactions, emerges notable factor maintaining myocardial cell homeostasis influencing progression cardiovascular disorders. Some disorders, such Keshan disease, are directly linked with environmental deficiency. Nevertheless, precise extent system remains unclear, marked by contradictory findings existing literature. High selenium levels associated an increased risk hypertension, while lower concentrations heart failure atrial fibrillation. Although some trials shown potential effectiveness specific groups patients, large cohort supplementation attempts generally yielded unsatisfactory outcomes. Consequently, there persists significant need further research aimed at delineating patient cohorts that would benefit from supplementation.

Language: Английский

Citations

10
Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective DOI Creative Commons
Yansong Fu, Zhipeng Wang, Hong Qin

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 218 - 218

Published: April 12, 2024

Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent worldwide, affecting approximately two-fifths of global population. The pathogenesis MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in progression MAFLD, including lipids, carbohydrates, amino acids, micronutrients. In recent years, medicinal properties natural products have attracted widespread attention, numerous studies reported their efficacy ameliorating subsequently alleviating MAFLD. This review aims summarize metabolic-associated pathological mechanisms as well regulate pathways alleviate

Language: Английский

Citations

8