Galen Medical Journal,
Journal Year:
2023,
Volume and Issue:
12
Published: Dec. 18, 2023
Social
anxiety
disorder
(SAD),
known
as
social
phobia,
is
considered
a
prevalent
psychiatric
characterized
by
constant
fear
of
positions.
Frequently,
phobia
occurs
with
other
mental
disorders
including
depression
and
substance
abuse
conditions.
Although
SAD
one
the
most
common
types
disorders,
proper
management
may
be
compromised
in
recurrent
comorbidity
due
to
clinicians’
focus
on
secondary
complications.
Moreover,
despite
description
polygenic
complex
condition,
few
altered
genetic
epigenetic
factors
are
identified
causative
agents.
Over
past
decades,
several
studies
have
suggested
polymorphisms
serotonergic
dopaminergic-related
genes
etiology
phobia.
Serotonin,
hand,
necessary
neurotransmitter
central
nervous
system
(CNS),
involved
variety
disease
processes
Nevertheless,
exact
mechanism
serotonin-dependent
development
efficacy
pharmacotherapies
not
fully
understood.
The
current
study
aimed
review
mechanisms
which
develops
discuss
strategies
that
based
serotonin
metabolism.
Physiologia Plantarum,
Journal Year:
2024,
Volume and Issue:
176(6)
Published: Nov. 1, 2024
As
global
climate
change
intensifies,
the
occurrence
and
severity
of
various
abiotic
stresses
will
significantly
threaten
plant
health
productivity.
Drought
stress
(DS)
is
a
formidable
obstacle,
disrupting
normal
functions
through
specific
morphological,
physiological,
biochemical,
molecular
mechanisms.
Understanding
how
plants
navigate
DS
paramount
to
mitigating
its
adverse
effects.
In
response
DS,
synthesize
or
accumulate
growth
regulators
(PGRs),
including
phytohormones,
neurotransmitters,
gasotransmitters,
polyamines,
which
present
promising
sustainable
green
chemical
strategies
adapt
tolerate
conditions.
These
PGRs
orchestrate
crucial
structure
function
adjustments,
activating
defense
systems
modulating
cellular-level
responses,
transcript
levels,
transcription
factors,
metabolic
genes,
stress-responsive
candidate
proteins.
However,
efficacy
these
molecules
in
depends
on
species,
applied
PGR
dose,
treatment
type,
duration
exposure,
stages.
Thus,
exploring
integrated
impact
enhancing
fitness
tolerance
for
food
security
agriculture.
This
review
investigates
responses
explains
potential
exogenously
diverse
PGRs,
dissects
complex
chemistry
among
sheds
light
omics
approaches
harnessing
basis
tolerance.
updated
delivers
comprehensive
mechanistic
insights
leveraging
enhance
overall
under
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1635 - 1635
Published: Feb. 14, 2025
Endogenous
melatonin
(MEL)
and
abscisic
acid
(ABA)
are
involved
in
the
adaptation
of
plants
to
environmental
stresses.
The
application
exogenous
serotonin
(SER)
can
enhance
their
tolerance
abiotic
stress,
such
as
cold.
However,
mechanism
associated
with
serotonin-mediated
defense
against
cold-induced
damage
mangroves
is
still
poorly
understood.
In
this
study,
we
demonstrated
that
mangrove
(Kandelia
obovata)
seedlings
sprayed
200
μmol·L-1
exhibited
enhanced
cold
tolerance,
shown
by
reduced
leaves
loss
photosynthesis
when
exposed
low-temperature
conditions.
K.
obovata
upon
treatment
was
subsequently
investigated
transcriptomic
analysis.
Serotonin
caused
changes
differentially
expressed
genes
(DEGs)
regulation
ABA
biosynthesis
responses
stress.
Under
serotonin-treated
showed
a
significant
increase
endogenous
levels
ABA.
By
contrast,
under
normal
growth
conditions,
treated
displayed
no
substantial
change
level,
whereas
level
significantly
increased.
These
findings
might
play
an
important
role
resistance
effect
would
depend
on
activation
synthesis.
Journal of Integrative Plant Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
ABSTRACT
Serotonin
(5‐hydroxytryptamine
(5‐HT))
is
a
pineal
hormone
and
secondary
metabolite
related
to
various
hormonal
physiological
functions
at
the
organ,
tissue,
cellular
levels.
It
considered
increasingly
important
in
regulating
animal
behavior,
but
function
of
serotonin
plants
far
less
known.
According
recent
research,
vital
for
plant
growth,
development,
stress
responses,
achieved
through
transcriptional
phytohormonal
interplay.
Specifically,
this
review
addresses
critical
gaps
understanding
serotonin's
by
examining
its
biosynthesis,
metabolism,
multifaceted
role
mitigating
both
abiotic
stresses
(salinity,
drought,
heat,
cold,
heavy
metals)
as
well
biotic
challenges
(pathogens,
pests,
herbivores).
As
pivotal
player,
it
engages
variety
significant
molecular
interactions,
including
those
with
reactive
oxygen
nitrogen
species
(RONS),
phytohormones
such
auxin,
abscisic
acid
(ABA),
salicylic
(SA),
jasmonic
(JA),
ethylene
(ET),
cytokinin
(CK).
Advances
serotonin‐related
research
are
anticipated
offer
valuable
basis
uncovering
regulatory
pathways
which
impacts
resilience
crops
against
stress.
Plants,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1072 - 1072
Published: April 1, 2025
Heat
stress
is
one
of
the
major
factors
affecting
crop
growth
and
yield.
However,
molecular
mechanisms
underlying
rice
heat
tolerance
remain
largely
unclear.
In
this
study,
we
identified
characterized
high
temperature
sensitive
2
(hts2)
mutant,
which
highly
susceptible
to
stress.
Map-based
cloning
revealed
that
HTS2
encodes
a
cytochrome
P450
protein
(CYP71P1)
involved
in
serotonin
biosynthesis.
ubiquitously
expressed
across
plant
tissues
shows
strong
upregulation
response
The
mutation
significantly
impairs
basal
synthesis
rice,
heat-sensitive
phenotype
hts2
mutant
completely
rescued
by
exogenous
supplementation.
Compared
wild
type,
exhibits
reduced
antioxidant
capacity,
leading
excessive
reactive
oxygen
species
(ROS)
accumulation
severe
oxidative
damage,
ultimately
reducing
tolerance.
Furthermore,
disruption
affects
shock
response,
with
heat-induced
expression
HsfA2s
their
downstream
target
genes,
such
as
HSP18.0
(heat
18.0)
OsAPX2
(ascorbate
peroxidase
2),
markedly
depressed
mutant.
Our
results
suggest
pivotal
role
modulating
metabolism
maintaining
ROS
homeostasis
during
stress,
offering
new
perspectives
on
potential
strategies
enhance
resilience
Frontiers in Plant Science,
Journal Year:
2025,
Volume and Issue:
16
Published: April 4, 2025
Drought
stress
caused
by
climate
change
is
increasingly
affecting
the
productivity
and
quality
of
vegetable
crops
worldwide.
This
review
comprehensively
analyzes
physiological,
biochemical,
molecular
mechanisms
that
employ
to
cope
with
drought
stress.
In
particular,
it
highlights
significance
key
hormonal
regulation
pathways,
such
as
abscisic
acid
(ABA),
jasmonic
(JA),
ethylene
(ET),
which
play
crucial
roles
in
mediating
responses.
Additionally,
role
antioxidant
defense
systems
mitigating
oxidative
damage
reactive
oxygen
species
(ROS)
discussed.
Advances
agricultural
technologies,
use
smart
irrigation
biostimulants,
have
shown
promising
results
enhancing
resistance
optimizing
crop
yields.
Integrating
these
strategies
development
resistant
varieties
through
gene
editing
traditional
breeding
techniques
will
ensure
sustainable
production
stressed
environments.
aims
support
future
research
into
enhance
tolerance
secure
global
food
supply.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 19, 2024
Serotonin,
also
known
as
5-hydroxyamine,
is
an
indoleamine
that
plays
crucial
roles
a
neurotransmitter
and
hormone
regulator
in
various
physiological
processes
across
the
animal
kingdom.
This
essential
signaling
molecule
synthesized
from
aromatic
amino
acid
tryptophan
found
virtually
all
living
organisms.
Over
last
few
years,
enormous
research
has
been
done
on
this
biomolecule.
In
plants,
they
are
to
be
involved
several
metabolic
developmental
functions.
Despite
its
widespread
importance
plants
still
many
things
understand
about
mechanism
of
action
Therefore,
chapter
focuses
current
knowledge
role
serotonin
plants.
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology,
Journal Year:
2024,
Volume and Issue:
158(5), P. 1006 - 1014
Published: Aug. 26, 2024
Serotonin
is
a
well-known
animal
hormone
and
ubiquitous
monoamine.
In
recent
years,
its
presence
in
plants
has
attracted
the
attention
of
many
researchers.
plants,
serotonin
as
signaling
plays
pivotal
role
hormonal
crosstalk,
regulating
antioxidant
metabolism
developmental
processes
under
abiotic
stresses.
Among
stresses,
salt
stress
considerably
influences
Guizotia
abyssinica
growth
physio-chemical
functions.
The
effect
exogenous
was
assessed
to
ameliorate
harmful
salinity
at
different
levels.
All
parameters,
chlorophyll
pigments,
gas
exchange
indicators,
nitrate
reductase
activity
were
decreased
all
levels
while
2-thiobarbituric
acid
reactive
substances
(TBARS),
proline,
activities
increased.
improved
length
roots
shoots,
basal
diameter,
leaf
number,
area,
width
length,
root
dry
matter,
stem
leaves
a,
b,
fluorescence,
transpiration
rate,
stomatal
conductance,
photosynthetic
relative
water
content,
use
efficiency,
condition.
Moreover,
upregulation
enzymes
evoked
by
further
enhanced.
Taken
together,
inhibited
performance
G.
abyssinica,
however,
application
fortified
tolerance
mitigating
membrane
damage
improving
assimilatory
functions,
plant
status
defense
metabolism,
thereby
lowering
adverse
effects
on
various
physio-biochemical
