Identification of Putative Causal Relationships between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review DOI Creative Commons
Nonkululeko Avril Mbatha, Aganze Gloire-Aimé Mushebenge, Andile Khathi

et al.

Physiologia, Journal Year: 2024, Volume and Issue: 4(2), P. 149 - 181

Published: April 8, 2024

Prediabetes, a pivotal phase in glucose metabolism between normalcy and diabetes, exerts profound influence on the aging process risk of age-related diseases. This comprehensive review delves into intricate web blood-based biomarkers that collectively expedite senescence, marking transition from state health to complications. Key findings underscore significance diverse biomarkers, such as telomere length, p16INK4a, senescence-associated secretory phenotype (SASP) factors, DNA methylation clocks, advanced glycation end products (AGEs), inflammatory oxidative stress markers, circulating hormones, additional factors folate, B12, osteocalcin. Not only do these serve indicators senescence but they also actively fuel chronic inflammation, stress, metabolic dysregulation, all which contribute accelerated aging. The implications this understanding are profound, prediabetes emerges critical period an individual’s life, influencing various physiological systems, including vascular neural functions, hormonal regulation, bone health. Recognizing provides foundation for personalized intervention strategies mitigate complications promote healthy Future research directions call more array in-depth exploration their roles, development tailored precision medicine ensure holistic effective management prediabetes-induced its knowledge has far-reaching public clinical practice, emphasizing need early detection prediabetic individuals enhance quality life population with needs.

Language: Английский

Shenfu injection: a review of pharmacological effects on cardiovascular diseases DOI Creative Commons
Feifei Xu, Xiaofang Xie, HU Hai-yan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Decoction created more than 700 years ago. SFI has been widely used in China for over 30 treating cardiovascular diseases. The main components it include ginsenosides aconitum alkaloids. In recent years, role treatment diseases attracted much attention. pharmacological effects therapeutic applications are summarized here, highlighting features potential mechanisms developments, confirming that can play multiple ways promising drug

Language: Английский

Citations

10
Advances in electrochemical detection of B-type natriuretic peptide as a heart failure biomarker DOI Creative Commons
Yanjun Li, Haitao Xu, Shuang Chen

et al.

International Journal of Electrochemical Science, Journal Year: 2024, Volume and Issue: 19(9), P. 100748 - 100748

Published: Aug. 2, 2024

Heart failure (HF) is a global health crisis with an increasing prevalence, emphasizing the urgent need for effective diagnostic and monitoring strategies. B-type natriuretic peptide (BNP), sensitive specific biomarker, has revolutionized HF management by enabling early detection, risk stratification, treatment guidance. However, conventional methods BNP detection face limitations in sensitivity, specificity, real-time capabilities. Electrochemical biosensors have emerged as promising alternative, combining specificity of biological recognition elements sensitivity electrochemical transduction. This review explores principles, advancements, challenges development detection. Innovative biorecognition elements, signal amplification techniques, nanomaterial-based electrode modifications significantly improved analytical performance these biosensors, achieving impressive limits direct measurements complex samples. Furthermore, integration microfluidic platforms wearable/implantable devices opened new avenues continuous, levels, facilitating personalized precise interventions management.

Language: Английский

Citations

5
Modulating Signal Generation in Aptamer‐Based CNT‐FET Biosensors by Controlling the Functionalization Route DOI Creative Commons

Haosen Miao,

Gririraj Manoharan,

A. S. Lim

et al.

Advanced Sensor Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The identification of biomarkers is key to the early detection physiological dysfunction. Nanoscale field‐effect transistors (FETs) modified with target‐specific receptors enable direct target sensing, offering enhanced sensitivity due nanoscale channel confinement. In this regard, single‐walled carbon nanotubes (SWCNTs) have emerged as strong candidates for development transistor‐based biosensors. Understanding structural parameters that affect sensing performance in such electrical platforms essential their reliable and controllable use. Here, investigated how different assembly strategies employed construction aptamer‐based SWCNT‐FET biosensors can dramatically signal generation, conductance increasing or decreasing same aptamer‐cortisol recognition event. a cortisol‐binding DNA aptamer exhibiting well‐characterized conformational behavior employed, model receptor explore influence surface functionalization on SWCNT‐based performance. Through combined optical characterization, elucidated conformation governs local electrostatic changes within Debye length, which turn modulates gating devices. This work offers insight into effective design functionalized electrostatically active molecular receptors.

Language: Английский

Citations

0
Advances in nanotechnological approaches for the detection of early markers associated with severe cardiac ailments DOI
Jie Wang, Haifeng Zhang,

Weiping Wan

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(16), P. 1487 - 1506

Published: July 2, 2024

Mortality from cardiovascular disease (CVD) accounts for over 30% of all deaths globally, necessitating reliable diagnostic tools. Prompt identification and precise diagnosis are critical effective personalized treatment. Nanotechnology offers promising applications in diagnostics, biosensing drug delivery prevalent diseases. Its integration into care enhances accuracy, enabling early intervention tailored treatment plans. By leveraging nanoscale innovations, healthcare professionals can address the complexities CVD progression customize interventions based on individual patient needs. Ongoing advancements nanotechnology continue to shape landscape medicine, offering potential improved outcomes reduced mortality rates these pervasive

Language: Английский

Citations

2
USING ARTIFICIAL INTELLIGENCE FOR BIOMARKER ANALYSIS IN CLINICAL DIAGNOSTICS DOI
П. В. Селиверстов, V. Kutsenko,

V. G. Gorelova

et al.

Molekulyarnaya Meditsina (Molecular medicine), Journal Year: 2024, Volume and Issue: unknown, P. 31 - 40

Published: Nov. 6, 2024

Introduction. Artificial intelligence (AI) technologies are becoming crucial in clinical diagnostics due to their ability process and interpret large volumes of data. The implementation AI for biomarker analysis opens new opportunities personalized medicine, offering more accurate individualized approaches disease diagnosis treatment. relevance this review stems from the need systematize recent advances application analysis, which is critical early prediction chronic non-communicable diseases (NCDs). Material methods. peer-reviewed scientific publications reports leading research centers over past five years was conducted. Studies on algorithms analyzing genomic, proteomic, metabolomic biomarkers were reviewed, including machine learning methods deep neural networks. Special attention paid integration multi-marker panels improving accuracy cardiovascular, digestive, respiratory, endocrine system diseases, as well oncological neurodegenerative pathologies. Results. has significantly increased sensitivity specificity diagnostics, especially complex cases requiring multiple parameters. effectiveness been demonstrated lung, breast, colorectal cancer, cardiovascular complications NCDs progression, diabetes mellitus Alzheimer’s disease. AI’s significant contribution discovery biomarkers, optimization treatment, improvement therapeutic strategies noted. Conclusion. use become a breakthrough medical particularly oncology, cardiology, diseases. technology allows data about various contributes creating models prediction. Further development associated with advancement overcoming ethical regulatory barriers, will expand capabilities practice.

Language: Английский

Citations

1
Identification of Putative Causal Relationships between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review DOI Creative Commons
Nonkululeko Avril Mbatha, Aganze Gloire-Aimé Mushebenge, Andile Khathi

et al.

Physiologia, Journal Year: 2024, Volume and Issue: 4(2), P. 149 - 181

Published: April 8, 2024

Prediabetes, a pivotal phase in glucose metabolism between normalcy and diabetes, exerts profound influence on the aging process risk of age-related diseases. This comprehensive review delves into intricate web blood-based biomarkers that collectively expedite senescence, marking transition from state health to complications. Key findings underscore significance diverse biomarkers, such as telomere length, p16INK4a, senescence-associated secretory phenotype (SASP) factors, DNA methylation clocks, advanced glycation end products (AGEs), inflammatory oxidative stress markers, circulating hormones, additional factors folate, B12, osteocalcin. Not only do these serve indicators senescence but they also actively fuel chronic inflammation, stress, metabolic dysregulation, all which contribute accelerated aging. The implications this understanding are profound, prediabetes emerges critical period an individual’s life, influencing various physiological systems, including vascular neural functions, hormonal regulation, bone health. Recognizing provides foundation for personalized intervention strategies mitigate complications promote healthy Future research directions call more array in-depth exploration their roles, development tailored precision medicine ensure holistic effective management prediabetes-induced its knowledge has far-reaching public clinical practice, emphasizing need early detection prediabetic individuals enhance quality life population with needs.

Language: Английский

Citations

0