Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 9, 2022
Endocannabinoids
(eCBS)
are
endogenously
derived
lipid
signaling
molecules
that
serve
as
tissue
hormones
and
interact
with
multiple
targets,
mostly
within
the
endocannabinoid
system
(ECS).
The
ECS
is
a
highly
conserved
regulatory
involved
in
homeostatic
regulation,
organ
formation,
immunomodulation
of
chordates.
term
"cannabinoid"
evolved
from
distinctive
class
plant
compounds
found
Cannabis
sativa,
an
ancient
herb,
due
to
their
action
on
CB1
CB2
receptors.
CB1/2
receptors
primary
targets
for
eCBs,
but
effects
not
limited
ECS.
Due
high
interest
extensive
research
ECS,
knowledge
its
constituents
physiological
role
substantial
still
growing.
Crosstalk
targeting
common
features
endogenous
compounds.
Cannabimimetic
can
be
divided
according
origin,
natural
or
synthetic,
including
phytocannabinoids
(pCB's)
synthetic
cannabinoids
(sCB's).
(ECS)
consists
receptors,
transporters,
enzymes,
molecules.
In
this
review,
we
focus
Cys-loop
belong
membrane-bound
pentameric
ligand
gated
ion
channels,
each
family
comprising
subunits.
Mammalians
possess
GABA
type
A
(GABAAR),
glycine
(GlyR),
serotonin
3
(5-HT3R),
nicotinic
acetylcholine
(nAChR).
Several
studies
have
shown
different
modulatory
CBs
members
receptor
family.
We
highlight
existing
knowledge,
especially
subunits
protein
domains
binding
sites
possible
pharmacological
epilepsy
chronic
pain.
further
discuss
potential
first
line
treatments
epilepsy,
pain
other
neuropsychiatric
conditions,
indicated
by
polypharmacology
therapeutic
profile.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 16201 - 16201
Published: Dec. 19, 2022
Dysmenorrhoea
effects
up
to
90%
of
women
reproductive
age,
with
medical
management
options
including
over-the-counter
analgesia
or
hormonal
contraception.
There
has
been
a
recent
surge
in
medicinal
cannabis
research
and
its
analgesic
properties.
This
paper
aims
critically
investigate
the
current
for
pain
relief
discuss
potential
application
treat
dysmenorrhoea.
Relevant
keywords,
cannabis,
pain,
cannabinoids,
tetrahydrocannabinol,
dysmenorrhoea,
clinical
trial,
have
searched
PubMed,
EMBASE,
MEDLINE,
Google
Scholar,
Cochrane
Library
(Wiley)
databases
trial
website
(clinicaltrials.gov).
To
identify
relevant
studies
this
paper,
84
papers
were
reviewed
20
discarded
as
irrelevant.
review
evaluated
cannabis-based
medicines
their
mechanism
properties
relation
relief.
It
also
tabulated
all
trials
carried
out
investigating
highlighted
side
effects.
In
addition,
safety
toxicology
barriers
use
are
highlighted.
Two-thirds
summarised
confirmed
positive
outcomes,
major
reported
nausea,
drowsiness,
dry
mouth.
conclusion,
promising
applications
The
global
market
size
was
valued
at
USD
11.0
billion
2021
is
expected
expand
compound
annual
growth
rate
(CAGR)
21.06%
from
2022
2030.
will
encourage
academic
well
pharmaceutical
device
industries
study
unmet
disorders.
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 9, 2022
Endocannabinoids
(eCBS)
are
endogenously
derived
lipid
signaling
molecules
that
serve
as
tissue
hormones
and
interact
with
multiple
targets,
mostly
within
the
endocannabinoid
system
(ECS).
The
ECS
is
a
highly
conserved
regulatory
involved
in
homeostatic
regulation,
organ
formation,
immunomodulation
of
chordates.
term
"cannabinoid"
evolved
from
distinctive
class
plant
compounds
found
Cannabis
sativa,
an
ancient
herb,
due
to
their
action
on
CB1
CB2
receptors.
CB1/2
receptors
primary
targets
for
eCBs,
but
effects
not
limited
ECS.
Due
high
interest
extensive
research
ECS,
knowledge
its
constituents
physiological
role
substantial
still
growing.
Crosstalk
targeting
common
features
endogenous
compounds.
Cannabimimetic
can
be
divided
according
origin,
natural
or
synthetic,
including
phytocannabinoids
(pCB's)
synthetic
cannabinoids
(sCB's).
(ECS)
consists
receptors,
transporters,
enzymes,
molecules.
In
this
review,
we
focus
Cys-loop
belong
membrane-bound
pentameric
ligand
gated
ion
channels,
each
family
comprising
subunits.
Mammalians
possess
GABA
type
A
(GABAAR),
glycine
(GlyR),
serotonin
3
(5-HT3R),
nicotinic
acetylcholine
(nAChR).
Several
studies
have
shown
different
modulatory
CBs
members
receptor
family.
We
highlight
existing
knowledge,
especially
subunits
protein
domains
binding
sites
possible
pharmacological
epilepsy
chronic
pain.
further
discuss
potential
first
line
treatments
epilepsy,
pain
other
neuropsychiatric
conditions,
indicated
by
polypharmacology
therapeutic
profile.
