Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117296 - 117296
Published: Aug. 20, 2024
Over
the
past
decades,
cancer
immunotherapy
has
encountered
challenges
such
as
immunogenicity,
inefficiency,
and
cytotoxicity.
Consequently,
exosome-based
gained
rapid
traction
a
promising
alternative.
Exosomes,
type
of
extracellular
vesicles
(EVs)
ranging
from
50
to
150
nm,
are
self-originating
exhibit
fewer
side
effects
compared
traditional
therapies.
Exosome-based
encompasses
three
significant
areas:
vaccination,
co-inhibitory
checkpoints,
adoptive
T-cell
therapy.
Each
these
fields
leverages
inherent
advantages
exosomes,
demonstrating
substantial
potential
for
individualized
tumor
therapy
precision
medicine.
This
review
aims
elucidate
reasons
behind
promise
nanoparticles
therapies
by
examining
their
characteristics
summarizing
latest
research
advancements
in
immunotherapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 4024 - 4024
Published: April 4, 2024
The
animal
gut
microbiota,
comprising
a
diverse
array
of
microorganisms,
plays
pivotal
role
in
shaping
host
health
and
physiology.
This
review
explores
the
intricate
dynamics
microbiome
animals,
focusing
on
its
composition,
function,
impact
host–microbe
interactions.
composition
intestinal
microbiota
animals
is
influenced
by
ecology,
including
factors
such
as
temperature,
pH,
oxygen
levels,
nutrient
availability,
well
genetic
makeup,
diet,
habitat,
stressors,
husbandry
practices.
Dysbiosis
can
lead
to
various
gastrointestinal
immune-related
issues
impacting
overall
productivity.
Extracellular
vesicles
(EVs),
particularly
exosomes
derived
from
play
crucial
intercellular
communication,
influencing
transporting
bioactive
molecules
across
barriers
like
brain
barriers.
Dysregulation
gut–brain
axis
has
implications
for
disorders
highlighting
potential
microbiota-derived
EVs
disease
progression.
Therapeutic
approaches
modulate
probiotics,
prebiotics,
microbial
transplants,
phage
therapy,
offer
promising
strategies
enhancing
performance.
Studies
investigating
effects
therapy
have
shown
results,
with
improving
food
safety
poultry
production
systems.
Understanding
complex
interactions
between
provides
valuable
insights
into
mechanisms
underlying
their
Further
research
this
field
essential
developing
effective
therapeutic
interventions
management
promote
well-being
animals.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 709 - 709
Published: May 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 10, 2025
Alzheimer's
disease
(AD)
is
a
distinctive
form
of
dementia
characterized
by
age-related
cognitive
decline
and
memory
impairment.
A
key
hallmark
AD
the
irreversible
overaccumulation
beta-amyloid
(Aβ)
in
brain,
associated
with
neuroinflammation
neuronal
death.
Although
Aβ
clearance
immunoregulation
have
been
major
therapeutic
strategies
for
AD,
highly
selective
transport
across
blood–brain
barrier
(BBB)
negatively
affects
delivery
efficacy
drugs
without
ability
to
cross
BBB.
In
this
review,
we
discuss
potential
lipid-based
nanoparticles
(LBNs)
as
promising
vehicles
drug
treatment.
LBNs,
composed
phospholipid
mono-
or
bilayer,
attracted
attention
due
their
exceptional
cellular
penetration
capabilities
loading
capabilities,
which
also
facilitate
cargo
transcytosis
Recent
advances
development
engineering
LBNs
overcome
existing
limitations
current
clinical
approaches
treatment
addressing
off-target
effects
low
efficacy.
Here,
review
pathways
BBB,
well
various
types
therapy,
including
exosomes,
liposomes,
solid
lipid
(SLNs),
nanostructured
carriers
(NLCs),
elucidate
properties,
preparation
methodologies,
efficacy,
thereby
offering
innovative
avenues
novel
translation
therapy.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 7, 2025
Exosomes
are
small
extracellular
vesicles
of
endocytic
origin
released
by
various
cell
types.
They
consist
lipid
bilayers
containing
macromolecules
such
as
lipids,
proteins,
microRNAs,
growth
factors,
cytokines,
and
carbohydrates.
play
a
critical
role
in
the
diagnosis
treatment
diseases.
For
instance,
exosome
contents
have
been
utilized
biomarkers
body
fluids
(urine,
saliva,
serum)
to
identify
cancers,
autoimmune
diseases,
inflammatory
conditions
sepsis.
Due
their
size
ability
reach
tumor
microenvironments,
exosomes
also
used
carriers
for
chemotherapeutic
drugs
drug
delivery
systems.
Furthermore,
evidence
indicates
that
malignant
cells
release
into
microenvironment,
influencing
immune
paracrine
manner.
Additionally,
cell-derived
exosomes,
those
from
Natural
Killer
(NK)
or
cytotoxic
T
lymphocytes
(CTLs),
show
potential
therapeutic
agents
treating
malignancies
like
leukemia.
This
review
discusses
diagnostic
hematological
explores
these
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(6), P. 1210 - 1210
Published: June 3, 2023
Cigarette
smoke
(CS)
poses
a
significant
risk
factor
for
respiratory,
vascular,
and
organ
diseases
owing
to
its
high
content
of
harmful
chemicals
reactive
oxygen
species
(ROS).
These
substances
are
known
induce
oxidative
stress,
inflammation,
apoptosis,
senescence
due
their
exposure
environmental
pollutants
the
presence
enzymes.
The
lung
is
particularly
susceptible
stress.
Persistent
stress
caused
by
chronic
CS
can
lead
respiratory
such
as
obstructive
pulmonary
disease
(COPD),
fibrosis
(PF),
cancer.
Avoiding
pollutants,
like
cigarette
air
pollution,
help
mitigate
A
comprehensive
understanding
impact
on
lungs
requires
future
research.
This
includes
identifying
strategies
preventing
treating
well
investigating
underlying
mechanisms
behind
Thus,
this
review
aims
investigate
cellular
processes
induced
CS,
specifically
senescence,
associated
biomarkers.
Furthermore,
will
delve
into
alveolar
response
provoked
emphasizing
roles
potential
therapeutic
target
markers
in
inflammation
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(46), P. 43374 - 43387
Published: Nov. 9, 2023
Exosomes
are
nanoscale
vesicles
secreted
by
living
cells
that
have
similar
membrane
composition
to
parental
and
carry
a
variety
of
proteins,
lipids,
nucleic
acids.
Therefore,
exosomes
certain
biological
activities
play
an
important
role
in
intercellular
communication.
On
the
basis
its
potential
as
carrier
for
drug
delivery
systems,
been
engineered
compensate
shortage
natural
through
various
engineering
strategies
improving
efficiency,
enhancing
targeting
tissues
organs,
extending
circulating
half-life
exosomes.
This
review
focuses
on
loading
drugs
different
strategies,
discussions
exosome
surface
modification
summarizes
advantages
disadvantages
strategies.
In
addition,
this
provides
overview
recent
applications
number
refractory
relapsable
diseases.
has
provide
reference
further
research
development
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Sept. 13, 2023
Background:
In
recent
years,
extracellular
vesicles
have
been
recognized
as
important
mediators
of
intercellular
communication
through
the
transfer
active
biomolecules
(proteins,
lipids,
and
nucleic
acids)
across
plant
animal
kingdoms
considerable
roles
in
several
physiological
pathological
mechanisms,
showing
great
promise
new
therapeutic
strategies
for
a
variety
pathologies.
Methods:
this
study,
we
carefully
reviewed
numerous
articles
published
over
last
few
decades
on
general
knowledge
vesicles,
their
application
therapy
various
pathologies,
prospects
an
approach
future.
Results:
The
discovery
characterization
(EVs)
diverse
origins
biogenesis
altered
current
paradigm
communication,
opening
up
diagnostic
perspectives.
Research
into
these
EVs
released
by
mammalian
cells
has
revealed
involvement
number
such
embryonic
development,
immune
response,
tissue
regeneration,
cancer.
They
are
also
being
studied
potential
biomarkers
disease
diagnosis
vectors
drug
delivery.
Conclusion:
Nanovesicles
represent
powerful
tools
bioactive
molecules.
Their
molecular
composition
functions
can
vary
according
to
origin
(plant
mammalian),
so
formation,
composition,
biological
open
way
applications
which
is
arousing
growing
interest
scientific
community.
Clinical
Trial
Registration:
ClinicalTrials.gov
identifier:
NCT03608631.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: Feb. 21, 2024
The
regeneration
of
bone
defects
in
diabetic
patients
still
faces
challenges,
as
the
intrinsic
healing
process
is
impaired
by
hyperglycemia.
Inspired
discovery
that
endoplasmic
reticulum
(ER)
a
state
excessive
stress
and
dysfunction
under
hyperglycemia,
leading
to
osteogenic
disorder,
novel
engineered
exosome
proposed
modulate
ER
homeostasis
for
restoring
function
mesenchymal
stem
cells
(MSCs).
results
indicate
constructed
exosomes
efficiently
regulate
dramatically
facilitate
MSCs
hyperglycemic
niche.
Additionally,
underlying
therapeutic
mechanism
elucidated.
reveal
can
directly
provide
recipient
with
SHP2
activation
mitophagy
elimination
mtROS,
which
immediate
cause
dysfunction.
To
maximize
effect
exosomes,
high-performance
hydrogel
self-healing,
bioadhesive,
exosome-conjugating
properties
applied
encapsulate
vivo
application.
In
vivo,
evaluation
defect
repair
models
demonstrates
delivering
system
intensively
enhance
osteogenesis.
These
findings
crucial
insight
into
design
biological
homeostasis-based
tissue-engineering
strategies
regeneration.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6533 - 6533
Published: June 13, 2024
Extracellular
vesicles
(EVs)
hold
great
promise
for
clinical
application
as
new
diagnostic
and
therapeutic
modalities.
This
paper
describes
major
GMP-based
upstream
downstream
manufacturing
processes
EV
large-scale
production,
also
focusing
on
post-processing
technologies
such
surface
bioengineering
uploading
studies
to
yield
novel
EV-based
diagnostics
advanced
therapy
medicinal
products.
focuses
the
quality,
safety,
efficacy
issues
of
bioengineered
drug
candidates
before
first-in-human
studies.
Because
trials
involving
extracellular
are
global
rise,
this
encompasses
different
registered
clinical-trial
register
platforms,
with
varying
levels
advancement,
highlighting
growing
interest
in
EV-related
programs.
Navigating
regulatory
affairs
EVs
poses
real
challenges,
obtaining
marketing
authorization
medicines
remains
complex
due
lack
specific
guidelines
discusses
state-of-the-art
knowledge
date
products,
further
research
needs
safe
reliable
implementation
tools
settings.
Post-marketing
pharmacovigilance
products
is
presented,
mainly
addressing
topics
risk
assessment
management.
