International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2514 - 2514
Published: Feb. 21, 2024
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
characterized
by
the
gradual
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc),
resulting
reduced
dopamine
levels
striatum
and
eventual
onset
motor
symptoms.
Linalool
(3,7-dimethyl-1,6-octadien-3-ol)
monoterpene
aromatic
plants
exhibiting
antioxidant,
antidepressant,
anti-anxiety
properties.
The
objective
this
study
to
evaluate
neuroprotective
impacts
linalool
on
SH-SY5Y
cells,
primary
mesencephalic
cortical
treated
with
1-methyl-4-phenylpyridinium
ion
(MPP
Abstract
Depression
is
a
mood
disorder
characterized
by
abnormal
thoughts.
The
pathophysiology
of
depression
related
to
the
deficiency
serotonin
(5HT),
which
derived
from
tryptophan
(Trp).
Mitochondrial
dysfunction,
oxidative
stress,
and
neuroinflammation
are
involved
in
pathogenesis
depression.
Notably,
renin–angiotensin
system
(RAS)
depression,
different
findings
revealed
that
angiotensin‐converting
enzyme
inhibitors
(ACEIs)
angiotensin
receptor
blockers
(ARBs)
may
be
effective
However,
underlying
mechanism
for
role
dysregulated
brain
RAS‐induced
remains
speculative.
Therefore,
this
review
aimed
revise
conceivable
ACEIs
ARBs
how
these
agents
ameliorate
Dysregulation
RAS
triggers
development
progression
through
reduction
5HT
expression
brain‐derived
neurotrophic
factor
(BDNF)
induction
mitochondrial
neuroinflammation.
inhibition
central
classical
ARBS
activation
non‐classical
prevent
regulating
5HT,
BDNF,
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(12)
Published: June 1, 2024
Abstract
Parkinson
disease
(PD)
is
one
of
the
most
common
neurodegenerative
diseases
brain.
Of
note,
brain
renin‐angiotensin
system
(RAS)
intricate
in
PD
neuropathology
through
modulation
oxidative
stress,
mitochondrial
dysfunction
and
neuroinflammation.
Therefore,
RAS
by
angiotensin
receptor
blockers
(ARBs)
angiotensin‐converting
enzyme
inhibitors
(ACEIs)
may
be
effective
reducing
risk
neuropathology.
It
has
been
shown
that
all
components
including
peptides
enzymes
are
present
different
areas.
Brain
plays
a
critical
role
regulation
memory
cognitive
function,
controlling
central
blood
pressure.
However,
exaggerated
implicated
pathogenesis
PD.
Two
well‐known
pathways
recognized
including;
classical
pathway
which
mainly
mediated
AngII/AT1R
detrimental
effects.
Conversely,
non‐classical
mostly
ACE2/Ang1‐7/MASR
AngII/AT2R
beneficial
effects
against
Exaggerated
affects
viability
dopaminergic
neurons.
fundamental
mechanism
was
not
fully
elucidated.
Consequently,
purpose
this
review
to
disclose
mechanistic
In
addition,
we
try
revise
how
ACEIs
ARBs
can
developed
for
therapeutics
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2514 - 2514
Published: Feb. 21, 2024
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
characterized
by
the
gradual
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc),
resulting
reduced
dopamine
levels
striatum
and
eventual
onset
motor
symptoms.
Linalool
(3,7-dimethyl-1,6-octadien-3-ol)
monoterpene
aromatic
plants
exhibiting
antioxidant,
antidepressant,
anti-anxiety
properties.
The
objective
this
study
to
evaluate
neuroprotective
impacts
linalool
on
SH-SY5Y
cells,
primary
mesencephalic
cortical
treated
with
1-methyl-4-phenylpyridinium
ion
(MPP
