The Antioxidant Role of Aromatic Plant Extracts in Managing Neurodegenerative Diseases: A Comprehensive Review

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111253 - 111253

Published: Feb. 1, 2025

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Amyotrophic Lateral Sclerosis (ALS), others. They caused by lesions in cells tissues the central nervous system, resulting corresponding dysfunctions consequent decline functions. Neural extremely vulnerable to oxidative stress, which plays critical biological roles NDDs. Aromatic compounds found extensively natural plants have substantial effects anti-oxidative stress damage, not only wide range research applications cosmetics, foods, etc., but also frequently utilized treatment various system diseases. This review summarizes relevant mechanisms NDDs (AD, PD, HD, ALS) reviews aromatic such as polyphenols, terpenoids, flavonoids that can be used management neurodegenerative diseases, well their specific antioxidant action. will serve reference for future experimental studies on illnesses while offering fresh insights into clinical therapy.

Language: Английский

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Natural compounds as therapeutic candidates for spinocerebellar ataxia type 1: a computational approach

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 15, 2025

Language: Английский

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Plant-Derived Monoterpene Therapies in Parkinson’s Disease Models: Systematic Review and Meta-Analysis

Plants, Journal Year: 2025, Volume and Issue: 14(7), P. 999 - 999

Published: March 22, 2025

Monoterpenes (MTs) are plants' secondary metabolites and major components of essential oils (EOs), widely used in the pharmaceutical industry. However, its neuroprotective effects, particularly Parkinson's disease (PD) have not been fully demonstrated. PD is a progressive neurological disorder marked by dopaminergic neuron loss substantia nigra, motor symptoms being most reported ones. This review evaluates evidence supporting use MTs as potential agents. PubMed, SCOPUS, Google Scholar, ScienceDirect databases were searched for articles on murine models with any type administration. The PRISMA guidelines followed. After screening 405 records, 32 included systematic 30 meta-analysis. Fifteen MTs, commonly found EOs, identified therapeutic agents PD. meta-analysis revealed that administration improved performance, increased tyrosine hydroxylase levels, reduced oxidative stress markers (malondialdehyde) proinflammatory cytokines (IL-6, IL-1, TNF-α), enhanced antioxidant enzymes (catalase, superoxide dismutase) parkinsonian animals. anti-inflammatory properties appear to be key mechanisms mitigating neurodegeneration. further clinical research translate these findings into practical applications.

Language: Английский

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Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics

Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 31, 2025

Osteoporosis and kidney stones share several common pathophysiological risk factors, their association is well-established. However, previous studies have primarily focused on environmental mediators, such as diet, the precise mechanism linking these two conditions remains unclear. The relationship between osteoporosis was analyzed using weighted multivariate logistic regression, employing data from five cycles of National Health Nutrition Examination Survey (NHANES) 2007–2010, 2013–2014, 2017–2020. Gene expression Expression Omnibus (GEO) microarray database were integrated with machine learning techniques to identify key genes involved in both stones. Common targets then identified through Comparative Toxicogenomics Database (CTD) GeneCards. GMFA enrichment analysis performed shared biological pathways. Additionally, drug prediction molecular docking employed further investigate pharmacological relevance targets. Analysis NHANES confirmed a strong Weighted regression showed that (OR: 1.41; 95% CI 1.11–1.79; P < 0.001) bone loss 1.24; 1.08–1.43; significantly correlated an increased Three hub genes—WNT1, AKT1, TNF—were various analytical methods. revealed mTOR signaling pathway pathway. Molecular targets, demonstrating binding affinity drugs proteins involved, consistent findings. Bone associated Targeting may offer potential therapeutic approach for treating

Language: Английский

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Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson’s Models

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 917 - 917

Published: July 29, 2024

Parkinson's disease is one of the most prevalent neurological disorders affecting millions people worldwide. There a growing demand for novel and natural substances as complementary therapies. Essential oils their various compounds are highly investigated plant-based products potential treatment options common human diseases, such microbial infections, chronic neurodegenerative disorders. The present study focuses on beneficial effects linalool geraniol, major lavender (

Language: Английский

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