Targeting of AMPK/MTOR signaling in the management of atherosclerosis: Outmost leveraging DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Mayyadah H. Mohsin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 142933 - 142933

Published: April 8, 2025

Language: Английский

The beneficial role of autophagy in multiple sclerosis: Yes or No? DOI
Hayder M. Al‐kuraishy, Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 20(2), P. 259 - 274

Published: Sept. 15, 2023

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against

Language: Английский

Citations

35
The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer’s diseases DOI Creative Commons
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 13, 2023

Abstract Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans has different physiological functions including inhibiting release insulin and glucagon. Type 2 diabetes mellitus (T2DM) is an endocrine disorder due to relative insufficiency resistance (IR) associated with increased circulating hIAPP. Remarkably, hIAPP structural similarity beta (Aβ) can engage pathogenesis T2DM Alzheimer’s disease (AD). Therefore, present review aimed elucidate how acts as a link between AD. IR, aging low cell mass increase expression which binds membrane leading aberrant Ca 2+ activation proteolytic enzymes series events causing loss cells. Peripheral plays major role AD, high level AD risk patients. However, there no hard evidence for brain-derived Nevertheless, oxidative stress, mitochondrial dysfunction, chaperon-mediated autophagy, heparan sulfate proteoglycan (HSPG), immune response, zinc homeostasis could be possible mechanisms induction aggregation risk. In conclusion, increasing levels patients predispose them development progression Dipeptidyl peptidase 4 (DPP4) inhibitors glucagon-like peptide-1 (GLP-1) agonists attenuate by deposition hIAP.

Language: Английский

Citations

33
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation DOI Open Access

Haydar M. Al‐kuraishy,

Majid S. Jabir,

Ali K. Albuhadily

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

Citations

32
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 25, 2023

Abstract Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles the lysosomes for degradation elimination. The mechanistic target of rapamycin (mTOR) main negative regulator autophagy. mTOR pathway involved in regulating neurogenesis, synaptic plasticity, neuronal development excitability. Exaggerated activity associated with temporal lobe epilepsy, genetic acquired experimental epilepsy. In particular, complex 1 (mTORC1) mainly epileptogenesis. investigation autophagy’s involvement epilepsy has recently been conducted, focusing on critical role rapamycin, autophagy inducer, reducing severity induced seizures animal model studies. induction could be innovative therapeutic strategy managing Despite protective against epileptogenesis its status epilepticus (SE) perplexing might beneficial or detrimental. Therefore, present review aims revise possible

Language: Английский

Citations

29
The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects DOI
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, ‏Hebatallah M. Saad

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1671 - 1682

Published: May 9, 2023

Language: Английский

Citations

27
Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two DOI Creative Commons

Faisal Alanazi,

Hayder M. Al‐kuraishy, Αθανάσιος Αλεξίου

et al.

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(7), P. 3405 - 3416

Published: Aug. 4, 2023

Abstract Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer’s disease (AD). In addition, progressive neurodegeneration in AD may affect metabolism thyroid hormones (THs) brain causing local HPT. Hence, present review aimed to clarify potential association between AD. promotes by inducing production amyloid beta (A β ) tau protein phosphorylation with synaptic plasticity memory dysfunction. Besides, THs is dysregulated due accumulation A leading Additionally, can neuropathology through various mechanistic pathways including dysregulation transthyretin, oxidative stress, ER autophagy dysfunction mitochondrial dysfunction, inhibition brain-derived neurotrophic factor. Taken together there link AD, as adversely impacts reverse also true. Graphical

Language: Английский

Citations

26
The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads DOI

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(5), P. 2469 - 2480

Published: Oct. 28, 2023

Language: Английский

Citations

26
Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel DOI
Hayder M. Al‐kuraishy, Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102119 - 102119

Published: Nov. 4, 2023

Language: Английский

Citations

25
Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears DOI Creative Commons

Mubarak Alruwaili,

Hayder M. Al‐kuraishy, Αθανάσιος Αλεξίου

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(11), P. 3255 - 3269

Published: July 13, 2023

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury myelin sheath by immune cells. The clotting factor fibrinogen involved in pathogenesis MS triggering microglia and progress neuroinflammation. Fibrinogen level correlated with severity; consequently, inhibition cascade may reduce neuropathology. Thus, this review aimed clarify potential role how targeting affects Accumulation CNS occur independently or disruption blood–brain barrier (BBB) integrity MS. acts as transduction increases activation which induces progression inflammation, oxidative stress, neuronal injury. Besides, brain impairs remyelination process inhibiting differentiation oligodendrocyte precursor These findings proposed that associated neuropathology through interruption BBB integrity, induction neuroinflammation, demyelination suppressing oligodendrocytes. Therefore, and/or CD11b/CD18 receptors metformin statins might decrease In conclusion, expression pro-inflammatory effect on

Language: Английский

Citations

24
BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

Citations

15